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YCAD - Uncharacterized MFS-type transporter YcaD
UniProt: P21503 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11242
Length: 382 (357)
Sequences: 64888
Seq/Len: 181.76
YCAD
Paralog alert: 0.90 [within 20: 0.66] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
92_I 96_S 4.137 1.00
80_I 107_G 3.545 1.00
87_G 100_W 3.5 1.00
53_G 102_F 2.952 1.00
84_G 100_W 2.883 1.00
61_T 110_M 2.851 1.00
70_F 121_C 2.776 1.00
89_G 162_P 2.743 1.00
95_W 99_A 2.68 1.00
82_A 168_T 2.663 1.00
93_G 96_S 2.645 1.00
123_G 131_L 2.553 1.00
77_A 110_M 2.536 1.00
314_V 322_M 2.514 1.00
94_F 98_L 2.414 1.00
129_G 260_D 2.379 1.00
127_N 130_R 2.369 1.00
233_S 236_S 2.323 1.00
39_S 42_Q 2.309 1.00
57_G 106_V 2.235 1.00
84_G 107_G 2.234 1.00
84_G 103_V 2.204 1.00
281_A 291_A 2.184 1.00
124_T 127_N 2.151 1.00
247_A 293_F 2.122 1.00
71_N 75_Y 2.114 1.00
251_G 297_A 2.086 1.00
66_K 320_V 2.067 1.00
91_M 96_S 1.986 1.00
214_I 337_G 1.953 1.00
274_V 298_A 1.938 1.00
42_Q 94_F 1.895 1.00
315_E 318_Q 1.892 1.00
210_I 333_G 1.88 1.00
264_R 312_E 1.875 1.00
91_M 100_W 1.867 1.00
38_M 94_F 1.808 1.00
194_T 198_K 1.802 1.00
65_I 114_V 1.802 1.00
278_G 291_A 1.8 1.00
218_S 341_T 1.783 1.00
46_V 97_W 1.76 1.00
84_G 104_A 1.721 1.00
57_G 109_A 1.719 1.00
88_L 100_W 1.716 1.00
173_L 177_F 1.715 1.00
63_Y 67_R 1.709 1.00
49_S 102_F 1.701 1.00
69_G 72_R 1.695 1.00
75_Y 176_L 1.69 1.00
53_G 57_G 1.676 1.00
49_S 98_L 1.674 1.00
162_P 166_G 1.653 1.00
286_A 290_P 1.626 1.00
88_L 97_W 1.623 1.00
278_G 298_A 1.607 1.00
38_M 42_Q 1.596 1.00
257_R 261_K 1.575 1.00
263_G 266_L 1.575 1.00
75_Y 172_I 1.57 1.00
82_A 172_I 1.566 1.00
86_A 165_T 1.547 1.00
355_I 359_S 1.536 1.00
271_Q 301_T 1.518 1.00
31_L 34_A 1.511 1.00
72_R 76_L 1.483 1.00
96_S 100_W 1.444 1.00
244_L 296_G 1.443 1.00
130_R 260_D 1.433 1.00
195_S 198_K 1.431 1.00
232_V 236_S 1.425 1.00
195_S 318_Q 1.403 0.99
64_V 73_S 1.392 0.99
79_F 172_I 1.39 0.99
64_V 68_I 1.381 0.99
82_A 165_T 1.374 0.99
57_G 60_L 1.373 0.99
62_G 66_K 1.365 0.99
247_A 251_G 1.365 0.99
89_G 165_T 1.36 0.99
86_A 90_L 1.351 0.99
125_S 128_R 1.349 0.99
206_V 329_S 1.349 0.99
95_W 98_L 1.344 0.99
52_T 335_L 1.344 0.99
76_L 80_I 1.333 0.99
68_I 73_S 1.325 0.99
12_L 138_V 1.32 0.99
236_S 239_F 1.314 0.99
256_G 260_D 1.311 0.99
80_I 84_G 1.309 0.99
119_L 135_Y 1.289 0.99
148_L 242_A 1.286 0.99
258_L 262_F 1.283 0.99
60_L 63_Y 1.273 0.99
77_A 107_G 1.26 0.99
68_I 72_R 1.255 0.99
72_R 75_Y 1.253 0.99
254_P 257_R 1.251 0.99
343_M 347_N 1.246 0.98
87_G 90_L 1.236 0.98
228_N 234_N 1.226 0.98
344_L 348_F 1.225 0.98
66_K 321_A 1.224 0.98
40_T 346_Q 1.223 0.98
120_M 128_R 1.218 0.98
265_L 269_R 1.21 0.98
121_C 319_L 1.203 0.98
228_N 237_I 1.197 0.98
251_G 254_P 1.195 0.98
278_G 295_L 1.188 0.98
99_A 103_V 1.187 0.98
33_L 43_V 1.18 0.98
286_A 289_A 1.167 0.97
174_P 178_T 1.167 0.97
266_L 269_R 1.162 0.97
333_G 337_G 1.156 0.97
273_F 277_L 1.154 0.97
200_R 203_R 1.153 0.97
69_G 73_S 1.15 0.97
65_I 70_F 1.15 0.97
276_I 280_I 1.148 0.97
31_L 35_Q 1.144 0.97
284_S 287_A 1.138 0.97
48_S 335_L 1.137 0.97
28_L 154_S 1.136 0.97
266_L 270_V 1.132 0.97
87_G 96_S 1.131 0.97
53_G 105_G 1.131 0.97
155_T 235_A 1.13 0.97
197_L 203_R 1.126 0.97
227_L 232_V 1.123 0.97
82_A 169_L 1.119 0.96
73_S 76_L 1.117 0.96
310_A 326_L 1.111 0.96
278_G 294_I 1.108 0.96
226_Y 230_K 1.106 0.96
348_F 352_L 1.103 0.96
257_R 260_D 1.103 0.96
19_T 139_Y 1.1 0.96
148_L 152_K 1.098 0.96
83_A 87_G 1.09 0.96
45_V 339_S 1.088 0.96
41_W 346_Q 1.087 0.96
66_K 70_F 1.08 0.95
239_F 243_V 1.074 0.95
271_Q 298_A 1.073 0.95
45_V 49_S 1.069 0.95
130_R 134_A 1.067 0.95
274_V 278_G 1.064 0.95
128_R 312_E 1.058 0.95
318_Q 321_A 1.056 0.95
276_I 362_F 1.055 0.95
90_L 162_P 1.054 0.95
182_N 185_A 1.052 0.95
199_L 203_R 1.052 0.95
280_I 358_A 1.051 0.94
255_I 301_T 1.049 0.94
16_L 142_G 1.049 0.94
55_L 328_L 1.048 0.94
235_A 239_F 1.041 0.94
96_S 99_A 1.04 0.94
44_G 48_S 1.029 0.94
50_Y 54_N 1.027 0.94
246_S 250_L 1.026 0.94
342_A 346_Q 1.023 0.93
50_Y 105_G 1.023 0.93
217_G 334_S 1.014 0.93
202_A 206_V 1.011 0.93
166_G 170_A 1.009 0.93
50_Y 108_C 1.008 0.93
101_R 105_G 1.006 0.93
316_H 319_L 1.003 0.93
118_A 179_R 1.001 0.92
262_F 266_L 1.001 0.92
162_P 165_T 1.001 0.92
130_R 257_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3wdoA10.99481000.172Contact Map0.639
1pw4A10.99741000.176Contact Map0.493
2cfqA10.99481000.198Contact Map0.523
2gfpA20.95031000.199Contact Map0.195
4j05A20.99741000.2Contact Map0.6
3o7qA10.97911000.203Contact Map0.643
4ldsA20.99741000.251Contact Map0.622
4gc0A10.99741000.258Contact Map0.728
2xutA30.99741000.26Contact Map0.56
4jr9A10.96861000.278Contact Map0.607
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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