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OPENSEQ.org
FUCP - L-fucose-proton symporter
UniProt: P11551 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10352
Length: 438 (376)
Sequences: 60944
Seq/Len: 162.09
FUCP
Paralog alert: 0.90 [within 20: 0.63] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
115_M 119_L 4.074 1.00
100_L 130_G 3.57 1.00
107_L 123_G 3.465 1.00
109_W 213_M 3.111 1.00
104_G 123_G 2.916 1.00
73_G 125_F 2.914 1.00
118_T 122_V 2.882 1.00
102_A 219_V 2.827 1.00
81_A 133_C 2.723 1.00
116_N 119_L 2.72 1.00
90_Y 144_V 2.691 1.00
376_L 383_G 2.656 1.00
152_H 320_S 2.507 1.00
146_G 154_R 2.486 1.00
117_Y 121_L 2.486 1.00
97_G 133_C 2.484 1.00
293_T 296_F 2.448 1.00
59_T 62_Q 2.439 1.00
150_S 153_F 2.367 1.00
272_G 397_V 2.309 1.00
268_F 393_G 2.304 1.00
104_G 130_G 2.303 1.00
341_I 353_A 2.263 1.00
77_I 129_A 2.259 1.00
104_G 126_I 2.25 1.00
334_I 360_F 2.191 1.00
307_C 355_T 2.185 1.00
252_S 256_R 2.146 1.00
86_K 381_K 2.133 1.00
311_G 359_A 2.089 1.00
147_P 150_S 2.047 1.00
91_K 95_I 1.985 1.00
198_S 210_T 1.919 1.00
338_L 353_A 1.918 1.00
114_I 123_G 1.88 1.00
106_A 216_V 1.872 1.00
77_I 132_G 1.87 1.00
324_P 374_K 1.846 1.00
114_I 119_L 1.837 1.00
66_I 120_F 1.83 1.00
85_M 137_A 1.816 1.00
69_A 125_F 1.805 1.00
62_Q 117_Y 1.801 1.00
104_G 127_I 1.789 1.00
95_I 223_A 1.787 1.00
69_A 121_L 1.785 1.00
58_L 117_Y 1.752 1.00
323_A 326_K 1.732 1.00
338_L 360_F 1.73 1.00
83_I 87_K 1.714 1.00
276_A 401_M 1.672 1.00
99_F 223_A 1.658 1.00
102_A 223_A 1.656 1.00
108_F 123_G 1.641 1.00
73_G 77_I 1.64 1.00
95_I 227_M 1.611 1.00
416_L 420_L 1.605 1.00
58_L 62_Q 1.592 1.00
32_C 161_F 1.574 1.00
317_W 321_R 1.568 1.00
89_S 92_A 1.537 1.00
304_T 358_S 1.51 1.00
316_T 320_S 1.502 1.00
331_Y 363_I 1.495 1.00
108_F 120_F 1.487 1.00
88_L 93_G 1.479 1.00
92_A 96_T 1.478 1.00
119_L 123_G 1.475 1.00
253_R 256_R 1.473 1.00
51_Q 54_Q 1.462 1.00
292_M 296_F 1.457 1.00
84_L 93_G 1.434 1.00
77_I 80_P 1.425 1.00
153_F 320_S 1.416 1.00
84_L 88_L 1.412 1.00
82_G 86_K 1.409 1.00
213_M 217_A 1.405 0.99
96_T 100_L 1.397 0.99
318_L 322_F 1.386 0.99
148_E 151_G 1.385 0.99
296_F 299_N 1.384 0.99
24_Y 150_S 1.377 0.99
403_F 407_A 1.375 0.99
107_L 110_P 1.366 0.99
102_A 216_V 1.36 0.99
286_V 294_A 1.354 0.99
333_L 337_A 1.346 0.99
224_L 228_L 1.334 0.99
97_G 130_G 1.327 0.99
307_C 311_G 1.326 0.99
100_L 104_G 1.318 0.99
199_A 210_T 1.299 0.99
109_W 216_V 1.298 0.99
336_M 340_L 1.288 0.99
106_A 110_P 1.282 0.99
92_A 95_I 1.282 0.99
118_T 121_L 1.275 0.99
143_T 151_G 1.274 0.99
286_V 297_A 1.273 0.99
314_T 317_W 1.269 0.99
88_L 92_A 1.257 0.99
275_T 394_G 1.255 0.99
122_V 126_I 1.25 0.99
72_F 395_G 1.247 0.99
171_V 302_T 1.242 0.98
176_L 210_T 1.226 0.98
393_G 397_V 1.22 0.98
86_K 382_Y 1.201 0.98
325_H 329_A 1.196 0.98
261_R 265_L 1.193 0.98
338_L 357_C 1.19 0.98
326_K 329_A 1.189 0.98
284_Y 290_P 1.188 0.98
70_F 74_Y 1.187 0.98
60_N 406_D 1.181 0.98
144_V 380_T 1.181 0.98
142_V 158_A 1.178 0.98
326_K 330_A 1.177 0.98
102_A 220_L 1.174 0.98
331_Y 360_F 1.17 0.97
109_W 201_K 1.161 0.97
93_G 96_T 1.159 0.97
73_G 128_A 1.155 0.97
39_A 162_N 1.152 0.97
404_V 408_A 1.152 0.97
48_L 177_I 1.151 0.97
103_L 107_L 1.147 0.97
336_M 423_A 1.145 0.97
80_P 83_I 1.139 0.97
311_G 314_T 1.134 0.97
315_G 363_I 1.133 0.97
85_M 90_Y 1.132 0.97
34_L 134_L 1.125 0.97
334_I 338_L 1.117 0.96
336_M 419_A 1.116 0.96
53_Q 63_A 1.116 0.96
220_L 224_L 1.113 0.96
89_S 93_G 1.108 0.96
253_R 379_D 1.104 0.96
61_F 406_D 1.101 0.96
68_S 395_G 1.098 0.96
107_L 119_L 1.098 0.96
70_F 131_L 1.097 0.96
306_V 310_I 1.097 0.96
343_A 416_L 1.095 0.96
216_V 220_L 1.095 0.96
285_A 292_M 1.093 0.96
119_L 122_V 1.093 0.96
402_G 406_D 1.091 0.96
51_Q 55_A 1.089 0.96
82_G 381_K 1.086 0.96
217_A 221_L 1.086 0.96
171_V 175_S 1.085 0.96
55_A 201_K 1.085 0.96
338_L 356_L 1.083 0.96
331_Y 364_Q 1.069 0.95
260_W 264_V 1.066 0.95
270_Y 364_Q 1.063 0.95
65_L 399_P 1.062 0.95
255_A 261_R 1.059 0.95
317_W 320_S 1.059 0.95
153_F 157_L 1.058 0.95
98_L 223_A 1.053 0.95
65_L 69_A 1.05 0.94
151_G 374_K 1.045 0.94
34_L 94_I 1.036 0.94
95_I 99_F 1.033 0.94
340_L 419_A 1.03 0.94
53_Q 60_N 1.029 0.94
284_Y 288_E 1.029 0.94
95_I 226_I 1.028 0.94
319_I 367_T 1.021 0.93
174_Q 298_A 1.019 0.93
337_A 341_I 1.019 0.93
299_N 303_G 1.014 0.93
210_T 213_M 1.014 0.93
70_F 128_A 1.013 0.93
92_A 233_A 1.011 0.93
36_F 165_G 1.009 0.93
86_K 90_Y 1.009 0.93
308_F 362_S 1.008 0.93
323_A 327_V 1.008 0.93
352_I 356_L 1.002 0.92
372_G 387_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3o7qA10.97031000.236Contact Map0.641
4j05A20.95431000.265Contact Map0.616
1pw4A10.93151000.267Contact Map0.485
3wdoA10.88131000.281Contact Map0.637
2gfpA20.84471000.308Contact Map0.175
4gc0A10.90871000.333Contact Map0.729
2cfqA10.88581000.34Contact Map0.49
4ldsA20.8791000.341Contact Map0.635
2xutA30.8951000.348Contact Map0.552
4jr9A10.92241000.367Contact Map0.608
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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