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OPENSEQ.org
EMRD - Multidrug resistance protein D
UniProt: P31442 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11693
Length: 394 (366)
Sequences: 66449
Seq/Len: 181.55
EMRD
Paralog alert: 0.90 [within 20: 0.67] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
94_S 98_V 4.216 1.00
82_I 109_G 3.602 1.00
89_V 102_A 3.528 1.00
91_V 166_L 3.259 1.00
97_T 101_A 2.962 1.00
55_T 104_A 2.954 1.00
84_M 172_C 2.905 1.00
63_Y 112_V 2.858 1.00
86_A 102_A 2.854 1.00
72_R 123_D 2.841 1.00
95_S 98_V 2.731 1.00
328_F 335_A 2.614 1.00
79_G 112_V 2.593 1.00
125_Y 133_A 2.56 1.00
241_S 244_T 2.532 1.00
131_R 268_K 2.465 1.00
96_L 100_I 2.451 1.00
41_R 44_A 2.439 1.00
129_Q 132_H 2.382 1.00
59_S 108_M 2.355 1.00
259_G 311_F 2.319 1.00
86_A 109_G 2.29 1.00
86_A 105_M 2.282 1.00
68_D 333_G 2.197 1.00
126_E 129_Q 2.141 1.00
73_R 77_L 2.055 1.00
159_W 163_A 2.02 1.00
93_T 98_V 1.989 1.00
88_L 169_L 1.954 1.00
93_T 102_A 1.943 1.00
201_K 205_G 1.937 1.00
77_L 180_A 1.899 1.00
300_W 304_V 1.889 1.00
77_L 176_T 1.872 1.00
44_A 96_L 1.867 1.00
177_F 181_R 1.859 1.00
272_T 326_E 1.833 1.00
59_S 111_G 1.825 1.00
283_L 312_G 1.807 1.00
86_A 106_Q 1.8 1.00
51_A 104_A 1.799 1.00
217_I 346_G 1.787 1.00
48_V 99_L 1.779 1.00
40_V 96_L 1.776 1.00
84_M 176_T 1.746 1.00
51_A 100_I 1.745 1.00
67_S 116_M 1.729 1.00
255_A 307_A 1.714 1.00
55_T 59_S 1.698 1.00
90_A 102_A 1.691 1.00
81_S 176_T 1.661 1.00
65_P 69_R 1.645 1.00
71_G 74_P 1.628 1.00
265_R 269_R 1.6 1.00
40_V 44_A 1.574 1.00
221_A 350_L 1.562 1.00
98_V 102_A 1.56 1.00
84_M 169_L 1.548 1.00
90_A 99_L 1.511 1.00
166_L 170_V 1.508 1.00
240_L 244_T 1.495 1.00
298_N 301_T 1.493 1.00
66_I 75_V 1.486 1.00
70_V 75_V 1.476 1.00
33_D 36_R 1.475 1.00
271_S 274_M 1.47 1.00
14_V 140_G 1.467 1.00
74_P 78_V 1.464 1.00
178_S 182_W 1.455 1.00
89_V 92_T 1.451 1.00
64_G 68_D 1.444 1.00
264_G 268_K 1.429 1.00
91_V 169_L 1.423 1.00
66_I 70_V 1.407 0.99
88_L 92_T 1.406 0.99
59_S 62_F 1.405 0.99
127_R 130_L 1.4 0.99
78_V 82_I 1.393 0.99
97_T 100_I 1.377 0.99
132_H 268_K 1.377 0.99
262_F 265_R 1.377 0.99
82_I 86_A 1.367 0.99
79_G 109_G 1.353 0.99
101_A 105_M 1.341 0.99
266_P 270_F 1.34 0.99
290_I 305_P 1.329 0.99
160_N 163_A 1.324 0.99
85_L 89_V 1.314 0.99
235_G 242_S 1.3 0.99
121_P 137_L 1.299 0.99
54_L 348_G 1.293 0.99
202_T 205_G 1.291 0.99
74_P 77_L 1.287 0.99
70_V 74_P 1.267 0.99
122_R 130_L 1.263 0.99
42_E 359_Q 1.261 0.99
123_D 332_A 1.258 0.99
255_A 259_G 1.257 0.99
190_D 193_R 1.255 0.99
163_A 166_L 1.248 0.99
259_G 262_F 1.247 0.99
155_L 163_A 1.243 0.98
356_M 360_T 1.24 0.98
84_M 173_A 1.24 0.98
30_A 156_D 1.239 0.98
62_F 65_P 1.233 0.98
21_Q 141_I 1.227 0.98
55_T 107_G 1.221 0.98
225_A 354_S 1.217 0.98
244_T 247_I 1.215 0.98
324_A 339_V 1.199 0.98
75_V 78_V 1.195 0.98
89_V 98_V 1.195 0.98
346_G 350_L 1.19 0.98
213_L 342_L 1.189 0.98
68_D 334_T 1.184 0.98
74_P 185_E 1.184 0.98
157_T 243_M 1.183 0.98
300_W 303_L 1.182 0.98
130_L 326_E 1.173 0.98
91_V 162_R 1.169 0.97
235_G 245_V 1.169 0.97
35_A 45_V 1.168 0.97
16_L 113_G 1.166 0.97
150_L 250_I 1.164 0.97
67_S 72_R 1.163 0.97
43_G 359_Q 1.157 0.97
287_L 305_P 1.155 0.97
265_R 268_K 1.155 0.97
71_G 75_V 1.154 0.97
285_G 289_W 1.153 0.97
52_Y 110_T 1.152 0.97
120_L 183_M 1.147 0.97
207_S 210_N 1.13 0.97
263_A 315_M 1.126 0.97
64_G 333_G 1.126 0.97
170_V 174_G 1.125 0.97
98_V 101_A 1.123 0.97
33_D 37_D 1.123 0.97
80_M 176_T 1.115 0.96
252_P 310_F 1.102 0.96
179_M 183_M 1.097 0.96
233_L 238_L 1.092 0.96
50_G 352_S 1.089 0.96
355_A 359_Q 1.088 0.96
132_H 136_L 1.087 0.96
154_L 158_M 1.083 0.96
92_T 166_L 1.081 0.95
50_G 348_G 1.072 0.95
331_L 334_T 1.071 0.95
150_L 154_L 1.071 0.95
47_S 51_A 1.067 0.95
247_I 251_L 1.064 0.95
57_G 341_G 1.06 0.95
47_S 352_S 1.052 0.95
256_A 314_G 1.051 0.94
77_L 81_S 1.047 0.94
81_S 85_L 1.045 0.94
258_F 261_W 1.044 0.94
243_M 247_I 1.037 0.94
304_V 308_L 1.034 0.94
23_A 168_L 1.032 0.94
261_W 265_R 1.031 0.94
37_D 162_R 1.03 0.94
18_A 144_S 1.028 0.94
280_C 315_M 1.027 0.94
205_G 209_F 1.027 0.94
304_V 307_A 1.013 0.93
209_F 213_L 1.012 0.93
35_A 42_E 1.009 0.93
103_S 107_G 1.004 0.93
173_A 177_F 1.004 0.93
57_G 348_G 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.99751000.162Contact Map0.492
2gfpA20.94921000.175Contact Map0.193
3wdoA10.98731000.181Contact Map0.631
4j05A20.99241000.212Contact Map0.629
3o7qA10.97461000.222Contact Map0.622
2cfqA10.98221000.222Contact Map0.482
2xutA30.99751000.263Contact Map0.535
4ldsA20.98981000.28Contact Map0.62
4gc0A10.99241000.285Contact Map0.73
4apsA20.99491000.297Contact Map0.548
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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