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OPENSEQ.org
EXUT - Hexuronate transporter
UniProt: P0AA78 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12738
Length: 472 (407)
Sequences: 53619
Seq/Len: 131.74
EXUT
Paralog alert: 0.90 [within 20: 0.61] - ratio of genomes with paralogs
Cluster includes: AMPG ARAE ARAJ BCR CYNX DGOT DTPA DTPB DTPD EMRB EMRD EMRY ENTS EXUT FSR FUCP GALP GARP GLPT GUDP HCAT HSRA KGTP LACY LPLT MDFA MDTD MDTG MDTH MDTL MDTM MELB MHPT NANT NARK NARU NEPI NUPG PROP RHMT SETA SETB SETC SHIA SOTB TSGA UHPC UHPT UIDB XAPB XYLE YAAU YAGG YAJR YBJJ YCAD YDEE YDFJ YDHC YDHP YDIM YDIN YDJE YDJK YEAN YEBQ YEGT YFCJ YGAY YGCS YHHS YHJE YHJX YICJ YIHN YIHO YIHP YJDL YJHB YJIJ YJJL YNFM YQCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
136_G 140_G 4.551 1.00
124_L 151_A 3.631 1.00
131_A 144_A 3.312 1.00
133_A 208_I 3.275 1.00
139_G 143_V 3.168 1.00
97_A 146_G 3.086 1.00
126_A 214_S 2.984 1.00
128_F 144_A 2.92 1.00
114_T 165_E 2.893 1.00
137_S 140_G 2.818 1.00
394_F 402_A 2.698 1.00
105_A 154_A 2.65 1.00
121_F 154_A 2.62 1.00
138_W 142_A 2.582 1.00
173_S 328_P 2.581 1.00
301_N 304_E 2.504 1.00
128_F 151_A 2.413 1.00
167_F 175_A 2.396 1.00
83_S 86_Q 2.369 1.00
110_D 400_A 2.345 1.00
277_F 413_A 2.316 1.00
128_F 147_A 2.28 1.00
171_E 174_I 2.239 1.00
101_M 150_A 2.233 1.00
261_G 265_R 2.214 1.00
435_A 439_V 2.146 1.00
281_P 417_F 2.079 1.00
168_P 171_E 2.034 1.00
135_A 140_G 2.024 1.00
135_A 144_A 1.99 1.00
130_G 211_G 1.987 1.00
395_G 398_E 1.962 1.00
90_I 141_L 1.925 1.00
93_A 146_G 1.916 1.00
201_H 205_M 1.902 1.00
101_M 153_A 1.895 1.00
115_K 119_A 1.892 1.00
315_F 373_C 1.892 1.00
93_A 142_A 1.891 1.00
119_A 218_A 1.832 1.00
128_F 148_V 1.825 1.00
86_Q 138_W 1.8 1.00
358_M 371_L 1.788 1.00
123_V 218_A 1.78 1.00
109_L 158_A 1.776 1.00
319_G 377_F 1.74 1.00
82_I 138_W 1.733 1.00
132_T 144_A 1.714 1.00
221_W 225_Y 1.708 1.00
107_Y 111_V 1.706 1.00
56_T 182_G 1.689 1.00
325_Y 329_L 1.671 1.00
48_R 171_E 1.656 1.00
126_A 218_A 1.632 1.00
285_T 421_V 1.627 1.00
353_M 445_A 1.61 1.00
113_G 116_I 1.596 1.00
132_T 141_L 1.595 1.00
140_G 144_A 1.579 1.00
332_R 392_D 1.575 1.00
262_Q 398_E 1.573 1.00
131_A 134_L 1.569 1.00
116_I 120_M 1.566 1.00
108_V 117_G 1.556 1.00
82_I 86_Q 1.554 1.00
130_G 134_L 1.54 1.00
97_A 101_M 1.537 1.00
353_M 442_L 1.531 1.00
355_G 378_A 1.53 1.00
324_G 328_P 1.469 1.00
366_Y 370_M 1.469 1.00
262_Q 265_R 1.462 1.00
331_Q 335_G 1.458 1.00
169_A 172_R 1.449 1.00
219_M 223_I 1.448 1.00
96_A 415_T 1.436 1.00
240_D 243_I 1.435 1.00
120_M 124_L 1.431 1.00
202_S 205_M 1.429 1.00
112_L 117_G 1.428 1.00
300_F 304_E 1.416 1.00
75_T 78_E 1.409 1.00
273_A 409_S 1.408 1.00
124_L 128_F 1.406 0.99
119_A 222_L 1.4 0.99
304_E 307_M 1.396 0.99
284_G 414_S 1.393 0.99
106_G 110_D 1.392 0.99
315_F 319_G 1.387 0.99
101_M 104_V 1.385 0.99
233_H 236_D 1.38 0.99
108_V 112_L 1.362 0.99
92_A 415_T 1.349 0.99
143_V 147_A 1.333 0.99
58_G 155_M 1.331 0.99
174_I 328_P 1.326 0.99
355_G 371_L 1.311 0.99
133_A 211_G 1.305 0.99
235_T 238_E 1.292 0.99
322_L 325_Y 1.277 0.99
357_G 438_A 1.276 0.99
326_L 330_F 1.269 0.99
192_P 310_W 1.269 0.99
133_A 204_Q 1.269 0.99
439_V 443_L 1.257 0.99
197_A 205_M 1.251 0.99
110_D 401_T 1.251 0.99
165_E 399_V 1.247 0.99
293_F 298_Y 1.246 0.98
112_L 116_I 1.243 0.98
116_I 119_A 1.243 0.98
126_A 211_G 1.234 0.98
295_F 305_I 1.229 0.98
295_F 302_L 1.228 0.98
349_G 381_A 1.227 0.98
353_M 357_G 1.226 0.98
413_A 417_F 1.225 0.98
269_F 273_A 1.224 0.98
366_Y 369_I 1.221 0.98
121_F 151_A 1.216 0.98
264_L 270_W 1.211 0.98
110_D 114_T 1.206 0.98
423_A 427_T 1.204 0.98
139_G 142_A 1.203 0.98
63_Y 183_S 1.192 0.98
163_S 179_F 1.189 0.98
72_A 198_I 1.179 0.98
164_S 172_R 1.179 0.98
353_M 438_A 1.178 0.98
323_G 381_A 1.176 0.98
109_L 114_T 1.175 0.98
208_I 212_A 1.167 0.97
127_V 131_A 1.166 0.97
282_A 441_D 1.165 0.97
72_A 206_A 1.162 0.97
126_A 215_F 1.158 0.97
215_F 219_M 1.149 0.97
94_Y 152_E 1.148 0.97
97_A 149_G 1.144 0.97
60_V 186_G 1.141 0.97
352_L 378_A 1.139 0.97
106_G 400_A 1.135 0.97
79_E 204_Q 1.133 0.97
172_R 392_D 1.13 0.97
77_M 87_Y 1.13 0.97
64_L 190_A 1.129 0.97
205_M 208_I 1.125 0.97
212_A 216_I 1.123 0.97
94_Y 98_Y 1.123 0.97
422_G 426_D 1.122 0.97
58_G 118_Y 1.116 0.96
136_G 204_Q 1.113 0.96
364_N 367_V 1.113 0.96
348_L 352_L 1.112 0.96
370_M 373_C 1.109 0.96
390_S 406_T 1.104 0.96
73_A 87_Y 1.098 0.96
131_A 140_G 1.096 0.96
431_S 435_A 1.095 0.96
140_G 143_V 1.093 0.96
432_P 435_A 1.089 0.96
119_A 221_W 1.083 0.96
351_V 445_A 1.08 0.95
314_L 318_L 1.079 0.95
99_T 408_M 1.077 0.95
54_L 220_A 1.076 0.95
75_T 79_E 1.069 0.95
199_V 303_K 1.067 0.95
307_M 311_M 1.066 0.95
270_W 274_L 1.064 0.95
312_P 376_G 1.062 0.95
319_G 322_L 1.059 0.95
360_G 438_A 1.059 0.95
89_Y 419_L 1.059 0.95
117_G 120_M 1.059 0.95
442_L 446_L 1.058 0.95
65_T 125_W 1.057 0.95
327_P 385_A 1.052 0.95
195_V 306_A 1.052 0.95
134_L 208_I 1.051 0.94
84_T 426_D 1.051 0.94
424_L 428_I 1.048 0.94
192_P 196_W 1.047 0.94
104_V 107_Y 1.044 0.94
103_P 107_Y 1.041 0.94
122_A 218_A 1.04 0.94
354_I 358_M 1.039 0.94
89_Y 93_A 1.038 0.94
51_M 166_W 1.034 0.94
90_I 138_W 1.032 0.94
60_V 189_I 1.03 0.94
64_L 210_S 1.029 0.94
370_M 374_I 1.028 0.94
174_I 325_Y 1.026 0.94
224_F 227_H 1.025 0.93
174_I 178_Y 1.025 0.93
220_A 224_F 1.012 0.93
113_G 117_G 1.011 0.93
367_V 370_M 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1pw4A10.91741000.368Contact Map0.487
4j05A20.94281000.393Contact Map0.632
3wdoA10.85171000.406Contact Map0.647
3o7qA10.86021000.415Contact Map0.615
2cfqA10.85381000.431Contact Map0.458
2gfpA20.78391000.434Contact Map0.18
4gc0A10.89621000.435Contact Map0.716
4ldsA20.88561000.437Contact Map0.63
2xutA30.9111000.456Contact Map0.515
4jr9A10.87081000.465Contact Map0.611
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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