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RCSB - Capsular synthesis regulator component B
UniProt: P69407 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10821
Length: 216 (201)
Sequences: 30457
Seq/Len: 151.53

RCSB
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_L 34_E 3.53 1.00
16_L 36_E 2.93 1.00
39_T 61_G 2.623 1.00
20_R 34_E 2.619 1.00
9_A 41_L 2.428 1.00
37_D 61_G 2.423 1.00
154_K 157_E 2.366 1.00
65_G 73_Y 2.35 1.00
168_V 183_S 2.322 1.00
20_R 24_E 2.255 1.00
180_K 183_S 2.225 1.00
92_P 112_A 2.218 1.00
155_E 192_K 2.183 1.00
95_L 115_D 2.159 1.00
38_S 65_G 2.158 1.00
22_S 113_P 2.09 1.00
33_G 50_A 2.057 1.00
37_D 40_A 2.053 1.00
46_P 77_H 2.034 1.00
42_I 73_Y 2.023 1.00
5_N 30_N 1.949 1.00
66_D 69_T 1.86 1.00
35_F 44_N 1.855 1.00
160_R 164_E 1.843 1.00
36_E 40_A 1.812 1.00
185_Q 188_S 1.762 1.00
52_V 120_L 1.714 1.00
85_V 98_V 1.702 1.00
23_L 120_L 1.702 1.00
71_I 83_I 1.688 1.00
55_T 70_L 1.66 1.00
84_I 123_L 1.647 1.00
58_S 89_N 1.609 1.00
100_D 121_A 1.597 1.00
104_E 126_G 1.563 1.00
57_L 85_V 1.546 1.00
55_T 71_I 1.537 1.00
161_L 171_I 1.529 1.00
7_I 35_F 1.521 1.00
167_L 170_E 1.508 1.00
161_L 174_K 1.508 1.00
71_I 85_V 1.503 1.00
73_Y 76_R 1.5 1.00
85_V 103_I 1.463 1.00
65_G 69_T 1.437 1.00
10_D 16_L 1.436 1.00
166_F 174_K 1.435 1.00
89_N 94_I 1.435 1.00
53_L 81_L 1.433 1.00
105_G 119_A 1.4 0.99
75_K 104_E 1.388 0.99
9_A 59_M 1.386 0.99
61_G 65_G 1.375 0.99
38_S 70_L 1.373 0.99
33_G 48_L 1.368 0.99
5_N 33_G 1.363 0.99
42_I 70_L 1.34 0.99
44_N 48_L 1.326 0.99
68_I 101_L 1.32 0.99
195_V 204_Y 1.307 0.99
73_Y 77_H 1.291 0.99
43_N 47_K 1.283 0.99
33_G 44_N 1.28 0.99
69_T 72_K 1.27 0.99
57_L 68_I 1.258 0.99
44_N 47_K 1.247 0.99
13_P 36_E 1.246 0.98
161_L 166_F 1.244 0.98
39_T 65_G 1.236 0.98
29_V 121_A 1.216 0.98
39_T 43_N 1.203 0.98
42_I 65_G 1.189 0.98
152_S 192_K 1.186 0.98
28_W 121_A 1.186 0.98
35_F 41_L 1.184 0.98
91_N 94_I 1.182 0.98
186_K 190_M 1.173 0.98
45_L 74_I 1.172 0.98
184_S 187_K 1.167 0.97
181_T 185_Q 1.157 0.97
72_K 97_A 1.147 0.97
169_T 179_I 1.147 0.97
136_R 145_G 1.133 0.97
11_D 56_D 1.131 0.97
52_V 124_Q 1.114 0.96
40_A 43_N 1.111 0.96
6_V 29_V 1.096 0.96
93_A 97_A 1.088 0.96
169_T 173_K 1.087 0.96
41_L 45_L 1.082 0.96
123_L 126_G 1.081 0.95
159_L 201_L 1.071 0.95
19_I 86_L 1.066 0.95
68_I 97_A 1.062 0.95
40_A 44_N 1.056 0.95
157_E 160_R 1.037 0.94
27_E 117_P 1.036 0.94
9_A 53_L 1.026 0.94
10_D 59_M 1.015 0.93
122_A 127_K 1.009 0.93
44_N 50_A 1.007 0.93
59_M 70_L 1.005 0.93
7_I 41_L 1.004 0.93
166_F 170_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA20.97691000.113Contact Map0.622
4gvpA40.95831000.121Contact Map0.783
1a04A20.9631000.135Contact Map0.684
4hyeA20.93521000.141Contact Map0.822
3kloA40.97691000.174Contact Map0.45
1yioA10.95831000.183Contact Map0.717
1ys7A20.97221000.211Contact Map0.767
3q9sA10.93521000.219Contact Map0.679
4b09A120.97221000.232Contact Map0.667
1kgsA10.96761000.242Contact Map0.704

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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