| UniProt: | P08368 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11218 | ||
| Length: | 229 (223) | ||
| Sequences: | 27767 | ||
| Seq/Len: | 124.52 |
| CREB
Paralog alert: 0.94 [within 20: 0.55] - ratio of genomes with paralogs Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 16_A | 32_V | 3.476 | 1.00 | |
| 16_A | 34_E | 2.781 | 1.00 | |
| 37_L | 59_D | 2.567 | 1.00 | |
| 9_V | 39_V | 2.476 | 1.00 | |
| 20_V | 32_V | 2.47 | 1.00 | |
| 35_R | 59_D | 2.45 | 1.00 | |
| 158_Y | 161_L | 2.4 | 1.00 | |
| 193_R | 196_D | 2.396 | 1.00 | |
| 176_R | 196_D | 2.389 | 1.00 | |
| 31_E | 48_P | 2.335 | 1.00 | |
| 60_I | 68_Q | 2.314 | 1.00 | |
| 159_E | 205_K | 2.298 | 1.00 | |
| 20_V | 24_Q | 2.258 | 1.00 | |
| 87_E | 107_S | 2.243 | 1.00 | |
| 36_G | 60_I | 2.173 | 1.00 | |
| 90_R | 110_E | 2.101 | 1.00 | |
| 35_R | 38_P | 2.074 | 1.00 | |
| 44_R | 73_H | 2.014 | 1.00 | |
| 5_T | 29_A | 1.988 | 1.00 | |
| 40_L | 68_Q | 1.962 | 1.00 | |
| 22_M | 108_P | 1.957 | 1.00 | |
| 136_H | 149_F | 1.956 | 1.00 | |
| 133_R | 138_E | 1.894 | 1.00 | |
| 61_S | 64_E | 1.882 | 1.00 | |
| 217_N | 227_R | 1.842 | 1.00 | |
| 164_K | 168_K | 1.831 | 1.00 | |
| 34_E | 38_P | 1.809 | 1.00 | |
| 145_Q | 152_P | 1.8 | 1.00 | |
| 80_F | 93_G | 1.787 | 1.00 | |
| 198_H | 201_T | 1.78 | 1.00 | |
| 5_T | 31_E | 1.763 | 1.00 | |
| 50_V | 115_V | 1.742 | 1.00 | |
| 33_F | 42_K | 1.734 | 1.00 | |
| 79_L | 118_L | 1.72 | 1.00 | |
| 217_N | 225_S | 1.716 | 1.00 | |
| 23_L | 115_V | 1.705 | 1.00 | |
| 66_C | 78_V | 1.693 | 1.00 | |
| 55_V | 80_F | 1.67 | 1.00 | |
| 165_T | 179_L | 1.664 | 1.00 | |
| 99_D | 121_R | 1.648 | 1.00 | |
| 95_E | 116_R | 1.625 | 1.00 | |
| 56_G | 84_R | 1.614 | 1.00 | |
| 53_L | 66_C | 1.607 | 1.00 | |
| 139_L | 167_L | 1.598 | 1.00 | |
| 53_L | 65_L | 1.598 | 1.00 | |
| 138_E | 147_S | 1.574 | 1.00 | |
| 169_S | 172_R | 1.554 | 1.00 | |
| 7_W | 33_F | 1.551 | 1.00 | |
| 68_Q | 72_L | 1.536 | 1.00 | |
| 84_R | 89_D | 1.509 | 1.00 | |
| 66_C | 80_F | 1.483 | 1.00 | |
| 9_V | 57_L | 1.478 | 1.00 | |
| 165_T | 182_S | 1.477 | 1.00 | |
| 51_M | 76_L | 1.465 | 1.00 | |
| 175_S | 178_Q | 1.455 | 1.00 | |
| 80_F | 98_A | 1.441 | 1.00 | |
| 26_E | 112_C | 1.43 | 1.00 | |
| 36_G | 65_L | 1.427 | 1.00 | |
| 10_E | 16_A | 1.393 | 0.99 | |
| 40_L | 65_L | 1.382 | 0.99 | |
| 60_I | 64_E | 1.369 | 0.99 | |
| 63_F | 96_I | 1.367 | 0.99 | |
| 31_E | 42_K | 1.365 | 0.99 | |
| 71_A | 99_D | 1.363 | 0.99 | |
| 64_E | 67_R | 1.307 | 0.99 | |
| 199_I | 203_R | 1.296 | 0.99 | |
| 68_Q | 73_H | 1.29 | 0.99 | |
| 140_N | 143_A | 1.285 | 0.99 | |
| 100_D | 114_R | 1.283 | 0.99 | |
| 170_P | 174_W | 1.278 | 0.99 | |
| 55_V | 63_F | 1.273 | 0.99 | |
| 37_L | 60_I | 1.268 | 0.99 | |
| 41_D | 45_K | 1.254 | 0.99 | |
| 42_K | 45_K | 1.252 | 0.99 | |
| 219_H | 225_S | 1.229 | 0.98 | |
| 42_K | 46_Q | 1.228 | 0.98 | |
| 165_T | 174_W | 1.22 | 0.98 | |
| 27_G | 116_R | 1.206 | 0.98 | |
| 28_F | 116_R | 1.202 | 0.98 | |
| 174_W | 182_S | 1.176 | 0.98 | |
| 40_L | 60_I | 1.164 | 0.97 | |
| 144_A | 161_L | 1.164 | 0.97 | |
| 50_V | 119_L | 1.163 | 0.97 | |
| 86_E | 89_D | 1.162 | 0.97 | |
| 131_V | 138_E | 1.16 | 0.97 | |
| 33_F | 39_V | 1.15 | 0.97 | |
| 37_L | 41_D | 1.148 | 0.97 | |
| 43_A | 70_L | 1.138 | 0.97 | |
| 38_P | 41_D | 1.135 | 0.97 | |
| 118_L | 121_R | 1.132 | 0.97 | |
| 144_A | 222_M | 1.118 | 0.96 | |
| 194_T | 198_H | 1.116 | 0.96 | |
| 172_R | 178_Q | 1.116 | 0.96 | |
| 147_S | 152_P | 1.112 | 0.96 | |
| 141_E | 164_K | 1.108 | 0.96 | |
| 156_T | 205_K | 1.104 | 0.96 | |
| 139_L | 160_F | 1.098 | 0.96 | |
| 13_Q | 34_E | 1.097 | 0.96 | |
| 197_T | 200_K | 1.097 | 0.96 | |
| 67_R | 92_L | 1.085 | 0.96 | |
| 11_D | 54_D | 1.084 | 0.96 | |
| 6_V | 28_F | 1.077 | 0.95 | |
| 158_Y | 184_W | 1.075 | 0.95 | |
| 177_Q | 192_D | 1.074 | 0.95 | |
| 88_V | 92_L | 1.069 | 0.95 | |
| 7_W | 39_V | 1.061 | 0.95 | |
| 31_E | 46_Q | 1.06 | 0.95 | |
| 7_W | 48_P | 1.057 | 0.95 | |
| 56_G | 83_A | 1.05 | 0.94 | |
| 39_V | 43_A | 1.049 | 0.94 | |
| 177_Q | 181_D | 1.046 | 0.94 | |
| 9_V | 51_M | 1.045 | 0.94 | |
| 63_F | 92_L | 1.045 | 0.94 | |
| 38_P | 42_K | 1.041 | 0.94 | |
| 19_L | 81_L | 1.041 | 0.94 | |
| 57_L | 65_L | 1.04 | 0.94 | |
| 87_E | 91_L | 1.034 | 0.94 | |
| 91_L | 109_R | 1.033 | 0.94 | |
| 142_P | 172_R | 1.032 | 0.94 | |
| 134_I | 226_L | 1.029 | 0.94 | |
| 8_L | 30_V | 1.025 | 0.93 | |
| 117_T | 122_V | 1.025 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2gwrA | 1 | 0.9869 | 100 | 0.095 | Contact Map | 0.678 |
| 1ys7A | 2 | 0.9913 | 100 | 0.109 | Contact Map | 0.776 |
| 2oqrA | 1 | 0.9913 | 100 | 0.113 | Contact Map | 0.575 |
| 3r0jA | 2 | 0.9869 | 100 | 0.114 | Contact Map | 0.685 |
| 4b09A | 12 | 0.9956 | 100 | 0.144 | Contact Map | 0.679 |
| 1kgsA | 1 | 0.9782 | 100 | 0.145 | Contact Map | 0.714 |
| 1p2fA | 1 | 0.9476 | 100 | 0.167 | Contact Map | 0.743 |
| 2hqrA | 2 | 0.9389 | 100 | 0.17 | Contact Map | 0.677 |
| 3q9sA | 1 | 0.9389 | 100 | 0.176 | Contact Map | 0.682 |
| 3c3wA | 2 | 0.9214 | 100 | 0.282 | Contact Map | 0.629 |
Sequence Conservation (Image Generated using WebLogo v3)