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OPENSEQ.org

FIMZ - Fimbriae Z protein
UniProt: P0AEL8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11103
Length: 210 (202)
Sequences: 30858
Seq/Len: 152.76

FIMZ
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_R 34_K 3.517 1.00
16_R 36_D 2.881 1.00
20_E 34_K 2.597 1.00
39_R 61_G 2.588 1.00
9_M 41_T 2.43 1.00
37_D 61_G 2.402 1.00
62_T 70_R 2.337 1.00
167_N 182_S 2.274 1.00
153_R 156_T 2.271 1.00
20_E 24_Q 2.232 1.00
179_K 182_S 2.201 1.00
89_C 109_D 2.187 1.00
92_A 112_D 2.158 1.00
38_Y 62_T 2.113 1.00
154_E 191_K 2.092 1.00
22_L 110_Q 2.049 1.00
46_R 74_I 2.024 1.00
42_I 70_R 2.016 1.00
32_V 50_V 2.004 1.00
37_D 40_I 1.969 1.00
5_S 30_Q 1.958 1.00
159_R 163_S 1.836 1.00
35_T 44_Y 1.83 1.00
36_D 40_I 1.812 1.00
63_D 66_T 1.804 1.00
184_H 187_N 1.747 1.00
5_S 32_V 1.704 1.00
68_L 80_V 1.703 1.00
23_L 117_V 1.696 1.00
52_L 117_V 1.695 1.00
82_F 95_A 1.693 1.00
55_M 67_F 1.663 1.00
81_L 120_I 1.646 1.00
97_Q 118_Q 1.587 1.00
58_D 86_K 1.581 1.00
160_Y 173_K 1.565 1.00
101_N 123_G 1.553 1.00
57_I 82_F 1.552 1.00
55_M 68_L 1.526 1.00
166_S 169_E 1.515 1.00
160_Y 170_I 1.497 1.00
82_F 100_A 1.492 1.00
68_L 82_F 1.462 1.00
70_R 73_Q 1.458 1.00
26_N 114_F 1.444 1.00
62_T 66_T 1.433 1.00
7_I 35_T 1.432 1.00
53_I 78_V 1.426 1.00
10_D 16_R 1.426 1.00
86_K 91_Y 1.42 1.00
72_K 101_N 1.411 1.00
194_L 203_Y 1.395 0.99
165_L 173_K 1.389 0.99
102_G 116_A 1.384 0.99
9_M 59_L 1.374 0.99
42_I 67_F 1.345 0.99
38_Y 67_F 1.339 0.99
65_F 98_A 1.292 0.99
44_Y 48_R 1.291 0.99
134_Y 144_S 1.288 0.99
70_R 74_I 1.284 0.99
43_D 47_T 1.277 0.99
66_T 69_K 1.273 0.99
39_R 62_T 1.258 0.99
32_V 44_Y 1.257 0.99
57_I 65_F 1.244 0.98
44_Y 47_T 1.22 0.98
28_E 118_Q 1.217 0.98
160_Y 165_L 1.211 0.98
13_P 36_D 1.211 0.98
45_L 71_I 1.199 0.98
88_E 91_Y 1.197 0.98
132_L 136_K 1.185 0.98
29_L 118_Q 1.181 0.98
35_T 41_T 1.178 0.98
183_A 186_S 1.157 0.97
151_S 191_K 1.156 0.97
39_R 43_D 1.149 0.97
69_K 94_R 1.147 0.97
42_I 62_T 1.144 0.97
26_N 118_Q 1.142 0.97
52_L 121_L 1.138 0.97
168_K 178_N 1.132 0.97
180_T 184_H 1.123 0.97
11_T 56_D 1.121 0.97
158_L 200_L 1.109 0.96
40_I 43_D 1.104 0.96
185_K 189_Y 1.104 0.96
90_F 94_R 1.092 0.96
168_K 172_D 1.079 0.95
6_V 29_L 1.073 0.95
41_T 45_L 1.073 0.95
120_I 123_G 1.061 0.95
156_T 159_R 1.055 0.95
40_I 44_Y 1.053 0.95
165_L 169_E 1.047 0.94
19_I 83_L 1.039 0.94
65_F 94_R 1.036 0.94
32_V 48_R 1.034 0.94
169_E 173_K 1.017 0.93
9_M 53_I 1.015 0.93
33_L 48_R 1.012 0.93
58_D 85_S 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA20.99051000.098Contact Map0.633
4gvpA40.98571000.109Contact Map0.809
1a04A211000.113Contact Map0.711
4hyeA20.96191000.125Contact Map0.799
3kloA40.99521000.152Contact Map0.438
1yioA10.96191000.157Contact Map0.695
1ys7A20.99051000.162Contact Map0.762
3q9sA10.97141000.181Contact Map0.671
4b09A120.98571000.189Contact Map0.657
3r0jA20.98571000.198Contact Map0.675

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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