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UHPA - Transcriptional regulatory protein UhpA
UniProt: P0AGA6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11051
Length: 196 (193)
Sequences: 30149
Seq/Len: 156.21

UHPA
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_R 34_G 2.955 1.00
14_R 31_A 2.874 1.00
37_R 59_D 2.647 1.00
7_I 39_A 2.446 1.00
35_S 59_D 2.442 1.00
60_I 68_Q 2.364 1.00
141_R 144_Q 2.322 1.00
155_V 170_H 2.303 1.00
87_V 107_E 2.24 1.00
167_K 170_H 2.233 1.00
84_P 104_S 2.22 1.00
18_A 22_G 2.206 1.00
36_G 60_I 2.175 1.00
30_V 48_V 2.122 1.00
142_E 179_K 2.081 1.00
20_L 105_P 2.054 1.00
35_S 38_E 2.026 1.00
40_L 68_Q 2.007 1.00
3_T 28_Q 1.948 1.00
61_S 64_E 1.865 1.00
34_G 38_E 1.864 1.00
33_F 42_G 1.851 1.00
147_E 151_Q 1.842 1.00
172_H 175_N 1.812 1.00
21_L 112_V 1.727 1.00
14_R 32_E 1.708 1.00
50_V 112_V 1.704 1.00
53_C 65_L 1.701 1.00
77_M 90_A 1.684 1.00
3_T 30_V 1.674 1.00
66_L 75_T 1.672 1.00
18_A 31_A 1.633 1.00
76_I 115_V 1.619 1.00
56_S 81_H 1.601 1.00
92_N 113_H 1.595 1.00
55_I 77_M 1.584 1.00
18_A 32_E 1.565 1.00
5_A 33_F 1.556 1.00
53_C 66_L 1.544 1.00
148_K 161_E 1.526 1.00
154_A 157_E 1.497 1.00
96_R 118_G 1.482 1.00
77_M 95_A 1.48 1.00
66_L 77_M 1.478 1.00
148_K 158_I 1.453 1.00
8_D 14_R 1.446 1.00
81_H 86_L 1.444 1.00
51_C 73_M 1.435 1.00
60_I 64_E 1.429 1.00
68_Q 71_K 1.415 1.00
182_V 191_R 1.405 0.99
97_G 111_A 1.402 0.99
36_G 65_L 1.4 0.99
7_I 57_M 1.379 0.99
40_L 65_L 1.365 0.99
153_M 161_E 1.361 0.99
70_P 96_R 1.357 0.99
30_V 42_G 1.332 0.99
42_G 46_R 1.305 0.99
63_L 93_A 1.271 0.99
64_E 67_S 1.253 0.99
41_A 45_G 1.244 0.98
55_I 63_L 1.242 0.98
37_R 60_I 1.238 0.98
148_K 153_M 1.236 0.98
26_D 113_H 1.232 0.98
131_A 150_A 1.232 0.98
42_G 45_G 1.217 0.98
27_L 113_H 1.214 0.98
11_L 34_G 1.203 0.98
37_R 41_A 1.202 0.98
40_L 60_I 1.191 0.98
43_L 69_L 1.186 0.98
83_S 86_L 1.181 0.98
33_F 39_A 1.177 0.98
168_T 172_H 1.173 0.98
146_A 188_L 1.164 0.97
25_P 109_I 1.16 0.97
67_S 89_Q 1.156 0.97
171_V 174_A 1.156 0.97
139_T 179_K 1.147 0.97
9_D 54_D 1.144 0.97
156_K 166_P 1.135 0.97
173_R 177_M 1.132 0.97
50_V 116_A 1.118 0.96
38_E 41_A 1.11 0.96
156_K 160_A 1.106 0.96
4_V 27_L 1.105 0.96
39_A 43_L 1.086 0.96
85_A 89_Q 1.086 0.96
191_R 194_D 1.084 0.96
17_F 78_L 1.057 0.95
30_V 46_R 1.057 0.95
63_L 89_Q 1.053 0.95
144_Q 147_E 1.048 0.94
7_I 51_C 1.039 0.94
38_E 42_G 1.035 0.94
153_M 157_E 1.031 0.94
31_A 34_G 1.029 0.94
5_A 39_A 1.025 0.93
115_V 118_G 1.018 0.93
56_S 80_V 1.008 0.93
42_G 48_V 1.007 0.93
8_D 57_M 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA211000.015Contact Map0.621
4gvpA411000.025Contact Map0.777
4hyeA20.99491000.039Contact Map0.779
1a04A211000.05Contact Map0.676
3kloA40.99491000.082Contact Map0.458
1yioA10.98981000.085Contact Map0.7
3q9sA10.98471000.131Contact Map0.663
1ys7A20.98981000.133Contact Map0.757
4b09A120.98981000.136Contact Map0.65
1p2fA10.97451000.162Contact Map0.745

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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