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YHJB - Putative HTH-type transcriptional regulator YhjB
UniProt: P37640 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12246
Length: 200 (197)
Sequences: 30859
Seq/Len: 156.64

YHJB
Paralog alert: 0.94 [within 20: 0.58] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
13_I 31_G 3.183 1.00
13_I 33_S 2.971 1.00
36_D 58_G 2.678 1.00
34_Q 58_G 2.498 1.00
6_F 38_L 2.448 1.00
59_E 67_K 2.39 1.00
145_R 148_E 2.345 1.00
171_G 174_K 2.277 1.00
89_L 109_T 2.277 1.00
159_N 174_K 2.266 1.00
86_K 106_T 2.252 1.00
30_Q 47_E 2.237 1.00
17_K 21_Q 2.219 1.00
35_A 59_E 2.196 1.00
146_Q 183_R 2.157 1.00
34_Q 37_E 2.085 1.00
19_S 107_V 2.078 1.00
39_W 67_K 2.056 1.00
43_E 71_Q 2.016 1.00
2_Q 28_S 1.995 1.00
17_K 31_G 1.952 1.00
60_F 63_W 1.91 1.00
33_S 37_E 1.836 1.00
151_T 155_A 1.828 1.00
176_H 179_S 1.806 1.00
2_Q 30_Q 1.794 1.00
52_L 64_L 1.729 1.00
20_L 114_V 1.725 1.00
65_L 77_V 1.715 1.00
79_I 92_V 1.708 1.00
49_L 114_V 1.696 1.00
78_L 117_A 1.649 1.00
55_D 83_D 1.624 1.00
94_H 115_N 1.612 1.00
54_G 79_I 1.593 1.00
52_L 65_L 1.563 1.00
158_S 161_E 1.52 1.00
79_I 97_V 1.518 1.00
67_K 70_V 1.505 1.00
65_L 79_I 1.499 1.00
98_L 120_G 1.488 1.00
152_M 165_A 1.487 1.00
186_V 195_M 1.473 1.00
152_M 162_I 1.464 1.00
35_A 64_L 1.458 1.00
83_D 88_W 1.456 1.00
59_E 63_W 1.452 1.00
7_D 13_I 1.448 1.00
50_V 75_V 1.416 1.00
39_W 64_L 1.413 1.00
69_V 98_L 1.395 0.99
6_F 56_Q 1.392 0.99
30_Q 41_K 1.377 0.99
99_A 113_A 1.349 0.99
41_K 45_Y 1.322 0.99
62_Y 95_F 1.298 0.99
4_V 32_A 1.288 0.99
63_W 66_Q 1.283 0.99
32_A 41_K 1.278 0.99
36_D 59_E 1.277 0.99
40_Q 44_S 1.265 0.99
157_E 165_A 1.261 0.99
54_G 62_Y 1.25 0.99
67_K 71_Q 1.249 0.99
10_S 33_S 1.243 0.98
150_L 192_A 1.239 0.98
41_K 44_S 1.232 0.98
39_W 59_E 1.215 0.98
25_P 111_A 1.205 0.98
85_N 88_W 1.199 0.98
36_D 40_Q 1.193 0.98
42_L 68_T 1.191 0.98
131_T 135_D 1.19 0.98
175_A 178_E 1.189 0.98
27_V 115_N 1.188 0.98
66_Q 91_E 1.172 0.98
172_T 176_H 1.166 0.97
177_L 181_Y 1.159 0.97
160_K 170_T 1.157 0.97
8_R 53_D 1.149 0.97
143_S 183_R 1.137 0.97
49_L 118_A 1.122 0.97
13_I 32_A 1.12 0.96
30_Q 45_Y 1.119 0.96
26_G 115_N 1.113 0.96
37_E 40_Q 1.106 0.96
87_R 91_E 1.101 0.96
16_M 80_T 1.078 0.95
160_K 164_R 1.075 0.95
37_E 41_K 1.073 0.95
38_L 42_L 1.07 0.95
4_V 38_L 1.059 0.95
62_Y 91_E 1.057 0.95
148_E 151_T 1.049 0.94
6_F 50_V 1.045 0.94
41_K 47_E 1.029 0.94
55_D 82_T 1.026 0.94
56_Q 64_L 1.024 0.93
3_I 27_V 1.017 0.93
117_A 120_G 1.01 0.93
147_R 151_T 1.008 0.93
152_M 156_G 1.008 0.93
5_M 29_I 1.007 0.93
90_Q 108_E 1.002 0.92
116_S 121_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c3wA20.9951000.07Contact Map0.601
4gvpA40.9951000.072Contact Map0.777
4hyeA20.981000.091Contact Map0.801
1a04A20.9951000.1Contact Map0.655
1yioA10.9851000.116Contact Map0.676
3kloA40.9951000.121Contact Map0.452
1ys7A20.991000.154Contact Map0.752
4b09A120.9851000.165Contact Map0.631
3q9sA10.981000.175Contact Map0.654
1kgsA10.991000.184Contact Map0.68

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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