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YQHC - Uncharacterized HTH-type transcriptional regulator YqhC
UniProt: Q46855 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13013
Length: 318 (282)
Sequences: 5352
Seq/Len: 18.98
YQHC
Paralog alert: 0.75 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
264_L 301_F 4.272 1.00
222_K 225_E 4.01 1.00
218_R 222_K 3.765 1.00
276_M 284_R 3.499 1.00
266_K 269_M 3.27 1.00
253_T 261_N 2.871 1.00
220_E 262_Y 2.853 1.00
268_R 301_F 2.843 1.00
230_E 240_V 2.76 1.00
247_F 258_Y 2.612 1.00
271_I 278_A 2.569 1.00
219_I 259_L 2.389 1.00
274_D 309_A 2.387 1.00
267_A 293_F 2.369 1.00
75_S 116_A 2.274 1.00
261_N 300_Y 2.248 1.00
264_L 300_Y 2.237 1.00
217_K 221_N 2.204 1.00
79_I 88_R 2.194 1.00
270_M 284_R 2.188 1.00
79_I 86_V 2.177 1.00
297_F 308_D 2.146 1.00
270_M 276_M 2.082 1.00
218_R 227_L 2.058 1.00
306_G 310_A 2.044 1.00
182_I 185_E 1.959 1.00
228_S 231_Q 1.931 1.00
232_L 255_P 1.906 1.00
303_V 311_R 1.899 1.00
218_R 235_E 1.894 1.00
77_H 88_R 1.837 1.00
276_M 280_A 1.812 1.00
219_I 227_L 1.812 1.00
219_I 262_Y 1.771 1.00
220_E 258_Y 1.761 1.00
256_L 260_K 1.758 1.00
229_V 244_H 1.746 1.00
266_K 270_M 1.733 1.00
216_L 251_T 1.732 1.00
74_F 118_L 1.716 1.00
243_F 255_P 1.701 1.00
215_V 243_F 1.694 1.00
212_I 251_T 1.692 1.00
225_E 231_Q 1.684 1.00
215_V 236_A 1.672 1.00
238_M 243_F 1.663 1.00
277_K 280_A 1.659 1.00
274_D 281_A 1.65 1.00
223_Y 262_Y 1.626 1.00
230_E 234_A 1.623 1.00
280_A 283_M 1.598 1.00
188_Y 192_T 1.551 1.00
270_M 285_V 1.547 1.00
232_L 235_E 1.53 1.00
271_I 281_A 1.515 1.00
223_Y 266_K 1.512 1.00
278_A 281_A 1.51 1.00
271_I 309_A 1.501 1.00
75_S 91_A 1.463 1.00
168_V 192_T 1.461 1.00
215_V 235_E 1.446 1.00
255_P 259_L 1.423 1.00
215_V 232_L 1.42 1.00
290_A 294_S 1.416 1.00
267_A 285_V 1.39 0.99
281_A 285_V 1.381 0.99
211_L 236_A 1.377 0.99
67_E 121_N 1.358 0.99
281_A 309_A 1.354 0.99
295_R 299_R 1.351 0.99
65_M 69_G 1.34 0.99
265_H 268_R 1.339 0.99
263_R 285_V 1.338 0.99
280_A 284_R 1.332 0.99
244_H 254_S 1.33 0.99
292_Q 296_E 1.319 0.99
276_M 281_A 1.316 0.99
266_K 285_V 1.303 0.99
253_T 257_Q 1.303 0.99
231_Q 235_E 1.293 0.99
240_V 244_H 1.291 0.99
262_Y 266_K 1.291 0.99
294_S 304_T 1.281 0.99
77_H 90_D 1.281 0.99
242_A 246_N 1.28 0.99
90_D 93_E 1.28 0.99
269_M 273_H 1.277 0.99
238_M 242_A 1.275 0.99
241_S 245_H 1.265 0.99
303_V 307_E 1.263 0.99
279_S 283_M 1.254 0.99
229_V 255_P 1.247 0.99
256_L 292_Q 1.229 0.98
214_R 235_E 1.229 0.98
294_S 306_G 1.221 0.98
304_T 307_E 1.218 0.98
236_A 243_F 1.216 0.98
40_E 56_E 1.215 0.98
268_R 308_D 1.212 0.98
72_I 94_Y 1.212 0.98
65_M 103_F 1.205 0.98
264_L 296_E 1.205 0.98
185_E 189_Y 1.203 0.98
289_S 292_Q 1.199 0.98
264_L 287_Y 1.194 0.98
181_Q 188_Y 1.191 0.98
216_L 220_E 1.185 0.98
224_T 266_K 1.183 0.98
218_R 232_L 1.163 0.97
254_S 257_Q 1.155 0.97
263_R 286_G 1.152 0.97
211_L 238_M 1.151 0.97
242_A 245_H 1.151 0.97
279_S 290_A 1.137 0.97
289_S 295_R 1.137 0.97
71_I 119_R 1.132 0.97
293_F 305_P 1.126 0.97
275_G 281_A 1.117 0.96
261_N 265_H 1.109 0.96
231_Q 234_A 1.107 0.96
78_K 89_Y 1.103 0.96
248_K 251_T 1.099 0.96
75_S 114_P 1.096 0.96
214_R 236_A 1.094 0.96
239_S 242_A 1.09 0.96
81_Y 86_V 1.088 0.96
238_M 246_N 1.087 0.96
34_N 37_K 1.078 0.95
73_L 76_G 1.078 0.95
34_N 38_N 1.067 0.95
181_Q 184_R 1.066 0.95
69_G 119_R 1.063 0.95
63_P 103_F 1.061 0.95
216_L 258_Y 1.052 0.95
68_P 99_V 1.019 0.93
296_E 300_Y 1.018 0.93
181_Q 185_E 1.011 0.93
257_Q 260_K 1.011 0.93
270_M 281_A 1.005 0.93
272_I 308_D 1.001 0.92
212_I 215_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.84281000.42Contact Map0.649
3w6vA10.45281000.595Contact Map0.747
1bl0A10.37421000.596Contact Map0.705
3oouA10.33961000.596Contact Map0.766
3oioA10.35531000.597Contact Map0.749
3mn2A20.33331000.599Contact Map0.744
3mklA20.35851000.603Contact Map0.775
2k9sA10.33331000.605Contact Map0.538
3lsgA50.32081000.611Contact Map0.85
1d5yA40.349199.90.616Contact Map0.676
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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