| UniProt: | P05052 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10050 | ||
| Length: | 249 (236) | ||
| Sequences: | 12676 | ||
| Seq/Len: | 53.71 |
| APPY
Paralog alert: 0.79 [within 20: 0.30] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 189_M | 226_Y | 3.401 | 1.00 | |
| 201_Y | 209_K | 3.153 | 1.00 | |
| 148_N | 151_R | 3.145 | 1.00 | |
| 156_K | 166_E | 3.064 | 1.00 | |
| 144_I | 148_N | 3.048 | 1.00 | |
| 178_T | 186_D | 3.032 | 1.00 | |
| 193_K | 226_Y | 3.01 | 1.00 | |
| 146_S | 187_T | 2.877 | 1.00 | |
| 191_Y | 194_K | 2.876 | 1.00 | |
| 222_F | 233_Y | 2.717 | 1.00 | |
| 192_A | 218_F | 2.439 | 1.00 | |
| 186_D | 225_Y | 2.416 | 1.00 | |
| 195_L | 209_K | 2.296 | 1.00 | |
| 154_H | 157_D | 2.247 | 1.00 | |
| 145_I | 184_L | 2.228 | 1.00 | |
| 173_L | 183_I | 2.214 | 1.00 | |
| 189_M | 225_Y | 2.083 | 1.00 | |
| 15_D | 22_V | 2.066 | 1.00 | |
| 195_L | 201_Y | 2.062 | 1.00 | |
| 196_I | 203_I | 2.049 | 1.00 | |
| 201_Y | 205_V | 2.008 | 1.00 | |
| 195_L | 210_C | 1.922 | 1.00 | |
| 202_S | 205_V | 1.911 | 1.00 | |
| 191_Y | 195_L | 1.869 | 1.00 | |
| 11_C | 47_K | 1.856 | 1.00 | |
| 149_I | 187_T | 1.846 | 1.00 | |
| 15_D | 24_S | 1.831 | 1.00 | |
| 145_I | 187_T | 1.821 | 1.00 | |
| 228_V | 236_K | 1.818 | 1.00 | |
| 141_I | 169_I | 1.81 | 1.00 | |
| 138_T | 176_E | 1.807 | 1.00 | |
| 26_K | 29_S | 1.807 | 1.00 | |
| 144_I | 161_L | 1.788 | 1.00 | |
| 13_S | 24_S | 1.787 | 1.00 | |
| 164_T | 169_I | 1.772 | 1.00 | |
| 143_G | 147_F | 1.756 | 1.00 | |
| 231_S | 235_E | 1.739 | 1.00 | |
| 155_L | 170_K | 1.736 | 1.00 | |
| 181_T | 185_R | 1.732 | 1.00 | |
| 144_I | 153_W | 1.67 | 1.00 | |
| 10_I | 49_R | 1.652 | 1.00 | |
| 141_I | 162_I | 1.651 | 1.00 | |
| 17_I | 22_V | 1.648 | 1.00 | |
| 158_I | 180_F | 1.634 | 1.00 | |
| 204_N | 215_T | 1.616 | 1.00 | |
| 205_V | 209_K | 1.61 | 1.00 | |
| 112_L | 115_S | 1.608 | 1.00 | |
| 193_K | 233_Y | 1.607 | 1.00 | |
| 13_S | 26_K | 1.598 | 1.00 | |
| 168_L | 172_R | 1.594 | 1.00 | |
| 142_T | 176_E | 1.589 | 1.00 | |
| 192_A | 210_C | 1.57 | 1.00 | |
| 199_N | 234_F | 1.566 | 1.00 | |
| 219_I | 229_T | 1.555 | 1.00 | |
| 111_R | 118_A | 1.553 | 1.00 | |
| 179_S | 182_E | 1.52 | 1.00 | |
| 217_Y | 221_A | 1.488 | 1.00 | |
| 19_N | 37_I | 1.477 | 1.00 | |
| 205_V | 208_Q | 1.473 | 1.00 | |
| 166_E | 170_K | 1.464 | 1.00 | |
| 164_T | 168_L | 1.457 | 1.00 | |
| 194_K | 198_S | 1.457 | 1.00 | |
| 169_I | 180_F | 1.456 | 1.00 | |
| 146_S | 183_I | 1.454 | 1.00 | |
| 168_L | 171_K | 1.45 | 1.00 | |
| 156_K | 160_E | 1.43 | 1.00 | |
| 141_I | 158_I | 1.413 | 1.00 | |
| 17_I | 40_E | 1.412 | 1.00 | |
| 34_S | 37_I | 1.392 | 0.99 | |
| 228_V | 232_H | 1.383 | 0.99 | |
| 221_A | 224_D | 1.382 | 0.99 | |
| 149_I | 191_Y | 1.375 | 0.99 | |
| 204_N | 208_Q | 1.374 | 0.99 | |
| 151_R | 157_D | 1.36 | 0.99 | |
| 180_F | 184_L | 1.35 | 0.99 | |
| 206_V | 210_C | 1.346 | 0.99 | |
| 15_D | 42_P | 1.337 | 0.99 | |
| 167_S | 171_K | 1.333 | 0.99 | |
| 191_Y | 210_C | 1.331 | 0.99 | |
| 178_T | 182_E | 1.324 | 0.99 | |
| 219_I | 231_S | 1.309 | 0.99 | |
| 215_T | 219_I | 1.307 | 0.99 | |
| 187_T | 191_Y | 1.303 | 0.99 | |
| 214_S | 220_C | 1.293 | 0.99 | |
| 216_S | 219_I | 1.289 | 0.99 | |
| 92_F | 96_E | 1.283 | 0.99 | |
| 203_I | 206_V | 1.268 | 0.99 | |
| 157_D | 161_L | 1.267 | 0.99 | |
| 229_T | 232_H | 1.259 | 0.99 | |
| 142_T | 146_S | 1.257 | 0.99 | |
| 11_C | 27_K | 1.257 | 0.99 | |
| 111_R | 115_S | 1.245 | 0.98 | |
| 158_I | 161_L | 1.238 | 0.98 | |
| 115_S | 119_M | 1.231 | 0.98 | |
| 212_Y | 221_A | 1.224 | 0.98 | |
| 155_L | 180_F | 1.207 | 0.98 | |
| 201_Y | 206_V | 1.198 | 0.98 | |
| 137_F | 164_T | 1.171 | 0.98 | |
| 187_T | 190_R | 1.17 | 0.97 | |
| 199_N | 206_V | 1.166 | 0.97 | |
| 165_S | 168_L | 1.15 | 0.97 | |
| 220_C | 224_D | 1.148 | 0.97 | |
| 144_I | 158_I | 1.144 | 0.97 | |
| 137_F | 162_I | 1.139 | 0.97 | |
| 5_C | 39_R | 1.13 | 0.97 | |
| 170_K | 180_F | 1.126 | 0.97 | |
| 186_D | 190_R | 1.115 | 0.96 | |
| 111_R | 114_I | 1.101 | 0.96 | |
| 159_A | 166_E | 1.095 | 0.96 | |
| 188_R | 210_C | 1.087 | 0.96 | |
| 118_A | 122_K | 1.082 | 0.96 | |
| 9_F | 12_Q | 1.074 | 0.95 | |
| 185_R | 221_A | 1.062 | 0.95 | |
| 150_E | 209_K | 1.057 | 0.95 | |
| 150_E | 191_Y | 1.038 | 0.94 | |
| 25_F | 31_F | 1.016 | 0.93 | |
| 157_D | 160_E | 1.011 | 0.93 | |
| 219_I | 223_K | 1.01 | 0.93 | |
| 226_Y | 233_Y | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9558 | 100 | 0.194 | Contact Map | 0.629 |
| 1bl0A | 1 | 0.494 | 100 | 0.421 | Contact Map | 0.738 |
| 3oouA | 1 | 0.4257 | 100 | 0.423 | Contact Map | 0.78 |
| 3oioA | 1 | 0.4458 | 100 | 0.426 | Contact Map | 0.787 |
| 3mn2A | 2 | 0.4217 | 99.9 | 0.429 | Contact Map | 0.755 |
| 3w6vA | 1 | 0.5783 | 99.9 | 0.435 | Contact Map | 0.763 |
| 2k9sA | 1 | 0.4217 | 99.9 | 0.438 | Contact Map | 0.542 |
| 3mklA | 2 | 0.4779 | 99.9 | 0.438 | Contact Map | 0.796 |
| 3lsgA | 5 | 0.4056 | 99.9 | 0.444 | Contact Map | 0.875 |
| 4fe7A | 1 | 0.8996 | 99.9 | 0.449 | Contact Map | 0.773 |
Sequence Conservation (Image Generated using WebLogo v3)