| UniProt: | P32677 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11913 | ||
| Length: | 283 (239) | ||
| Sequences: | 11656 | ||
| Seq/Len: | 48.77 |
| YIJO
Paralog alert: 0.78 [within 20: 0.20] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 223_L | 260_T | 3.502 | 1.00 | |
| 177_Y | 181_R | 3.126 | 1.00 | |
| 189_E | 199_P | 3.113 | 1.00 | |
| 181_R | 184_S | 3.108 | 1.00 | |
| 235_L | 243_A | 3.098 | 1.00 | |
| 212_I | 220_H | 3.059 | 1.00 | |
| 179_D | 221_T | 2.999 | 1.00 | |
| 227_K | 260_T | 2.904 | 1.00 | |
| 225_H | 228_T | 2.901 | 1.00 | |
| 256_F | 267_Y | 2.816 | 1.00 | |
| 226_A | 252_F | 2.446 | 1.00 | |
| 229_L | 243_A | 2.375 | 1.00 | |
| 220_H | 259_N | 2.372 | 1.00 | |
| 178_I | 218_L | 2.333 | 1.00 | |
| 206_F | 217_Y | 2.285 | 1.00 | |
| 187_T | 190_S | 2.137 | 1.00 | |
| 223_L | 259_N | 2.118 | 1.00 | |
| 145_I | 148_S | 2.11 | 1.00 | |
| 229_L | 235_L | 2.077 | 1.00 | |
| 52_V | 57_G | 2.059 | 1.00 | |
| 230_L | 237_V | 2.043 | 1.00 | |
| 235_L | 239_E | 1.961 | 1.00 | |
| 229_L | 244_C | 1.956 | 1.00 | |
| 236_K | 239_E | 1.92 | 1.00 | |
| 50_E | 59_T | 1.906 | 1.00 | |
| 182_Y | 221_T | 1.894 | 1.00 | |
| 177_Y | 194_A | 1.892 | 1.00 | |
| 225_H | 229_L | 1.845 | 1.00 | |
| 178_I | 221_T | 1.841 | 1.00 | |
| 174_I | 202_L | 1.831 | 1.00 | |
| 48_E | 83_T | 1.815 | 1.00 | |
| 262_R | 270_Q | 1.81 | 1.00 | |
| 176_D | 180_E | 1.801 | 1.00 | |
| 171_F | 210_G | 1.789 | 1.00 | |
| 197_I | 202_L | 1.735 | 1.00 | |
| 47_L | 85_F | 1.72 | 1.00 | |
| 52_V | 59_T | 1.714 | 1.00 | |
| 265_S | 269_R | 1.706 | 1.00 | |
| 215_N | 219_N | 1.703 | 1.00 | |
| 188_R | 203_S | 1.692 | 1.00 | |
| 38_V | 74_N | 1.685 | 1.00 | |
| 174_I | 195_F | 1.677 | 1.00 | |
| 177_Y | 186_L | 1.665 | 1.00 | |
| 191_V | 214_F | 1.661 | 1.00 | |
| 41_P | 70_A | 1.658 | 1.00 | |
| 227_K | 267_Y | 1.65 | 1.00 | |
| 61_V | 64_D | 1.647 | 1.00 | |
| 50_E | 61_V | 1.633 | 1.00 | |
| 239_E | 243_A | 1.601 | 1.00 | |
| 238_K | 249_S | 1.601 | 1.00 | |
| 175_R | 210_G | 1.598 | 1.00 | |
| 54_T | 57_G | 1.576 | 1.00 | |
| 226_A | 244_C | 1.561 | 1.00 | |
| 253_C | 263_S | 1.531 | 1.00 | |
| 179_D | 217_Y | 1.526 | 1.00 | |
| 197_I | 201_Y | 1.516 | 1.00 | |
| 201_Y | 205_L | 1.503 | 1.00 | |
| 239_E | 242_H | 1.498 | 1.00 | |
| 201_Y | 204_H | 1.489 | 1.00 | |
| 228_T | 232_G | 1.47 | 1.00 | |
| 233_Y | 268_R | 1.456 | 1.00 | |
| 262_R | 266_E | 1.425 | 1.00 | |
| 42_R | 74_N | 1.423 | 1.00 | |
| 189_E | 193_Q | 1.422 | 1.00 | |
| 213_G | 216_E | 1.419 | 1.00 | |
| 174_I | 191_V | 1.414 | 1.00 | |
| 202_L | 214_F | 1.404 | 0.99 | |
| 199_P | 203_S | 1.402 | 0.99 | |
| 64_D | 116_R | 1.394 | 0.99 | |
| 240_V | 244_C | 1.394 | 0.99 | |
| 184_S | 190_S | 1.377 | 0.99 | |
| 238_K | 242_H | 1.374 | 0.99 | |
| 253_C | 265_S | 1.344 | 0.99 | |
| 214_F | 218_L | 1.34 | 0.99 | |
| 177_Y | 191_V | 1.337 | 0.99 | |
| 69_P | 72_G | 1.315 | 0.99 | |
| 221_T | 225_H | 1.312 | 0.99 | |
| 54_T | 75_F | 1.297 | 0.99 | |
| 52_V | 77_Q | 1.294 | 0.99 | |
| 212_I | 216_E | 1.286 | 0.99 | |
| 182_Y | 225_H | 1.284 | 0.99 | |
| 225_H | 244_C | 1.283 | 0.99 | |
| 263_S | 266_E | 1.281 | 0.99 | |
| 249_S | 253_C | 1.28 | 0.99 | |
| 235_L | 240_V | 1.274 | 0.99 | |
| 251_Y | 255_L | 1.266 | 0.99 | |
| 200_N | 204_H | 1.266 | 0.99 | |
| 144_L | 151_S | 1.261 | 0.99 | |
| 170_L | 197_I | 1.261 | 0.99 | |
| 248_D | 254_R | 1.256 | 0.99 | |
| 175_R | 179_D | 1.242 | 0.98 | |
| 250_N | 253_C | 1.24 | 0.98 | |
| 170_L | 195_F | 1.238 | 0.98 | |
| 246_F | 255_L | 1.232 | 0.98 | |
| 255_L | 258_K | 1.232 | 0.98 | |
| 48_E | 62_P | 1.217 | 0.98 | |
| 191_V | 194_A | 1.206 | 0.98 | |
| 190_S | 194_A | 1.206 | 0.98 | |
| 237_V | 240_V | 1.178 | 0.98 | |
| 188_R | 214_F | 1.17 | 0.97 | |
| 233_Y | 240_V | 1.143 | 0.97 | |
| 144_L | 148_S | 1.133 | 0.97 | |
| 222_R | 244_C | 1.128 | 0.97 | |
| 198_S | 201_Y | 1.124 | 0.97 | |
| 254_R | 258_K | 1.113 | 0.96 | |
| 221_T | 224_E | 1.082 | 0.96 | |
| 220_H | 224_E | 1.072 | 0.95 | |
| 253_C | 257_R | 1.071 | 0.95 | |
| 203_S | 214_F | 1.057 | 0.95 | |
| 151_S | 155_D | 1.055 | 0.95 | |
| 183_A | 225_H | 1.043 | 0.94 | |
| 46_V | 51_F | 1.035 | 0.94 | |
| 240_V | 268_R | 1.024 | 0.93 | |
| 144_L | 147_A | 1.015 | 0.93 | |
| 35_A | 73_W | 1.013 | 0.93 | |
| 46_V | 49_G | 1.011 | 0.93 | |
| 182_Y | 218_L | 1.011 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9223 | 100 | 0.285 | Contact Map | 0.637 |
| 3w6vA | 1 | 0.5053 | 100 | 0.497 | Contact Map | 0.756 |
| 3oouA | 1 | 0.3816 | 100 | 0.498 | Contact Map | 0.783 |
| 3oioA | 1 | 0.3993 | 100 | 0.501 | Contact Map | 0.782 |
| 3mn2A | 2 | 0.3746 | 100 | 0.504 | Contact Map | 0.752 |
| 1bl0A | 1 | 0.4417 | 100 | 0.504 | Contact Map | 0.737 |
| 2k9sA | 1 | 0.3746 | 100 | 0.511 | Contact Map | 0.539 |
| 3mklA | 2 | 0.424 | 100 | 0.513 | Contact Map | 0.799 |
| 3lsgA | 5 | 0.3604 | 99.9 | 0.517 | Contact Map | 0.875 |
| 1d5yA | 4 | 0.4134 | 99.9 | 0.531 | Contact Map | 0.701 |
Sequence Conservation (Image Generated using WebLogo v3)