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OPENSEQ.org

MARA - Multiple antibiotic resistance protein MarA
UniProt: P0ACH5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11434
Length: 127 (107)
Sequences: 20267
Seq/Len: 189.41

MARA
Paralog alert: 0.87 [within 20: 0.43] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_A 100_F 2.509 1.00
52_H 60_S 2.482 1.00
75_E 83_R 2.344 1.00
29_E 39_K 2.31 1.00
96_F 107_Y 2.247 1.00
17_W 21_N 2.202 1.00
19_E 61_R 2.161 1.00
65_E 68_Q 1.938 1.00
66_I 92_L 1.899 1.00
60_S 99_Y 1.895 1.00
69_K 83_R 1.892 1.00
63_M 100_F 1.88 1.00
14_I 42_L 1.776 1.00
27_S 30_K 1.765 1.00
21_N 24_S 1.739 1.00
17_W 34_R 1.696 1.00
46_F 57_Y 1.616 1.00
69_K 84_Y 1.597 1.00
75_E 79_Y 1.572 1.00
41_H 45_M 1.531 1.00
69_K 75_E 1.519 1.00
39_K 43_Q 1.511 1.00
102_V 110_T 1.476 1.00
76_P 79_Y 1.456 1.00
18_I 58_I 1.416 1.00
15_L 50_T 1.413 1.00
89_Q 93_T 1.399 0.99
55_G 59_R 1.339 0.99
78_L 89_Q 1.321 0.99
70_L 77_I 1.29 0.99
68_Q 72_E 1.289 0.99
40_W 44_R 1.284 0.99
63_M 99_Y 1.28 0.99
31_V 54_L 1.271 0.99
41_H 44_R 1.263 0.99
22_L 61_R 1.25 0.99
79_Y 82_E 1.238 0.98
52_H 56_Q 1.23 0.98
95_T 98_N 1.201 0.98
105_H 109_M 1.199 0.98
16_D 20_D 1.195 0.98
65_E 69_K 1.189 0.98
91_T 95_T 1.189 0.98
78_L 82_E 1.185 0.98
90_Q 93_T 1.171 0.98
79_Y 83_R 1.159 0.97
14_I 35_S 1.159 0.97
61_R 64_T 1.139 0.97
28_L 43_Q 1.128 0.97
37_Y 41_H 1.123 0.97
59_R 95_T 1.123 0.97
67_A 107_Y 1.121 0.97
102_V 106_K 1.118 0.96
15_L 19_E 1.116 0.96
61_R 65_E 1.103 0.96
59_R 98_N 1.065 0.95
11_I 50_T 1.043 0.94
86_F 95_T 1.026 0.94
66_I 84_Y 1.024 0.93
53_S 56_Q 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1bl0A111000.118Contact Map0.799
3gbgA10.913499.90.181Contact Map0.669
4fe7A10.913499.90.186Contact Map0.772
3oioA10.889899.90.208Contact Map0.799
3oouA10.850499.90.211Contact Map0.818
3w6vA10.929199.90.218Contact Map0.808
3mn2A20.834699.90.218Contact Map0.807
2k9sA10.834699.90.227Contact Map0.578
3lsgA50.803199.90.234Contact Map0.918
3mklA20.944999.90.237Contact Map0.843

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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