| UniProt: | Q47129 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13422 | ||
| Length: | 301 (267) | ||
| Sequences: | 7420 | ||
| Seq/Len: | 27.79 |
| FEAR
Paralog alert: 0.78 [within 20: 0.16] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 250_L | 289_F | 3.871 | 1.00 | |
| 206_D | 248_R | 3.859 | 1.00 | |
| 208_N | 211_E | 3.534 | 1.00 | |
| 204_L | 208_N | 3.505 | 1.00 | |
| 264_E | 272_H | 3.252 | 1.00 | |
| 252_F | 255_D | 3.007 | 1.00 | |
| 239_L | 247_N | 2.887 | 1.00 | |
| 217_E | 227_V | 2.858 | 1.00 | |
| 285_F | 296_Y | 2.801 | 1.00 | |
| 254_A | 289_F | 2.681 | 1.00 | |
| 253_C | 281_F | 2.519 | 1.00 | |
| 256_A | 273_W | 2.503 | 1.00 | |
| 247_N | 288_R | 2.454 | 1.00 | |
| 234_F | 244_Y | 2.393 | 1.00 | |
| 205_I | 245_I | 2.387 | 1.00 | |
| 256_A | 272_H | 2.383 | 1.00 | |
| 257_I | 266_L | 2.322 | 1.00 | |
| 82_I | 89_Q | 2.153 | 1.00 | |
| 80_Q | 91_Q | 2.112 | 1.00 | |
| 78_S | 115_K | 2.09 | 1.00 | |
| 256_A | 264_E | 2.046 | 1.00 | |
| 201_V | 223_T | 2.029 | 1.00 | |
| 209_I | 248_R | 2.025 | 1.00 | |
| 77_L | 117_I | 2.025 | 1.00 | |
| 264_E | 268_G | 2.022 | 1.00 | |
| 250_L | 288_R | 2.02 | 1.00 | |
| 205_I | 248_R | 1.948 | 1.00 | |
| 204_L | 214_L | 1.935 | 1.00 | |
| 253_C | 273_W | 1.929 | 1.00 | |
| 204_L | 222_E | 1.915 | 1.00 | |
| 82_I | 91_Q | 1.896 | 1.00 | |
| 291_M | 299_K | 1.888 | 1.00 | |
| 201_V | 230_L | 1.886 | 1.00 | |
| 225_M | 230_L | 1.886 | 1.00 | |
| 294_G | 298_R | 1.883 | 1.00 | |
| 203_T | 207_D | 1.84 | 1.00 | |
| 215_R | 218_W | 1.81 | 1.00 | |
| 206_D | 244_Y | 1.801 | 1.00 | |
| 252_F | 256_A | 1.79 | 1.00 | |
| 84_E | 89_Q | 1.7 | 1.00 | |
| 93_G | 96_D | 1.68 | 1.00 | |
| 219_I | 241_V | 1.664 | 1.00 | |
| 265_K | 268_G | 1.646 | 1.00 | |
| 174_Q | 178_C | 1.623 | 1.00 | |
| 242_A | 246_R | 1.616 | 1.00 | |
| 227_V | 231_Y | 1.61 | 1.00 | |
| 217_E | 221_G | 1.607 | 1.00 | |
| 239_L | 243_Q | 1.606 | 1.00 | |
| 254_A | 296_Y | 1.605 | 1.00 | |
| 80_Q | 93_G | 1.562 | 1.00 | |
| 175_A | 178_C | 1.557 | 1.00 | |
| 86_D | 104_R | 1.546 | 1.00 | |
| 216_P | 231_Y | 1.546 | 1.00 | |
| 71_F | 102_A | 1.511 | 1.00 | |
| 78_S | 94_A | 1.501 | 1.00 | |
| 240_V | 243_Q | 1.5 | 1.00 | |
| 282_S | 292_T | 1.5 | 1.00 | |
| 216_P | 241_V | 1.481 | 1.00 | |
| 241_V | 245_I | 1.476 | 1.00 | |
| 225_M | 229_S | 1.463 | 1.00 | |
| 219_I | 222_E | 1.461 | 1.00 | |
| 201_V | 219_I | 1.454 | 1.00 | |
| 268_G | 272_H | 1.449 | 1.00 | |
| 84_E | 107_S | 1.444 | 1.00 | |
| 230_L | 241_V | 1.439 | 1.00 | |
| 229_S | 232_R | 1.438 | 1.00 | |
| 262_D | 297_R | 1.432 | 1.00 | |
| 267_A | 278_Q | 1.426 | 1.00 | |
| 101_D | 104_R | 1.422 | 1.00 | |
| 209_I | 252_F | 1.422 | 1.00 | |
| 231_Y | 240_V | 1.416 | 1.00 | |
| 280_H | 284_V | 1.415 | 1.00 | |
| 228_R | 232_R | 1.403 | 0.99 | |
| 268_G | 271_F | 1.397 | 0.99 | |
| 282_S | 294_G | 1.352 | 0.99 | |
| 291_M | 295_E | 1.348 | 0.99 | |
| 229_S | 233_M | 1.346 | 0.99 | |
| 269_I | 297_R | 1.341 | 0.99 | |
| 211_E | 218_W | 1.338 | 0.99 | |
| 277_D | 283_T | 1.318 | 0.99 | |
| 72_Y | 106_C | 1.304 | 0.99 | |
| 178_C | 182_P | 1.303 | 0.99 | |
| 197_Q | 225_M | 1.296 | 0.99 | |
| 82_I | 109_Y | 1.291 | 0.99 | |
| 267_A | 271_F | 1.288 | 0.99 | |
| 266_L | 269_I | 1.286 | 0.99 | |
| 252_F | 273_W | 1.283 | 0.99 | |
| 204_L | 219_I | 1.27 | 0.99 | |
| 202_V | 206_D | 1.27 | 0.99 | |
| 280_H | 283_T | 1.27 | 0.99 | |
| 152_H | 156_Q | 1.266 | 0.99 | |
| 197_Q | 223_T | 1.266 | 0.99 | |
| 201_V | 222_E | 1.257 | 0.99 | |
| 262_D | 269_I | 1.256 | 0.99 | |
| 220_A | 227_V | 1.243 | 0.98 | |
| 264_E | 269_I | 1.235 | 0.98 | |
| 247_N | 251_D | 1.229 | 0.98 | |
| 76_Q | 81_A | 1.22 | 0.98 | |
| 202_V | 244_Y | 1.217 | 0.98 | |
| 48_T | 115_K | 1.212 | 0.98 | |
| 68_D | 106_C | 1.211 | 0.98 | |
| 66_S | 106_C | 1.21 | 0.98 | |
| 205_I | 214_L | 1.209 | 0.98 | |
| 292_T | 295_E | 1.207 | 0.98 | |
| 218_W | 222_E | 1.187 | 0.98 | |
| 255_D | 259_H | 1.186 | 0.98 | |
| 223_T | 230_L | 1.186 | 0.98 | |
| 275_F | 284_V | 1.179 | 0.98 | |
| 289_F | 296_Y | 1.172 | 0.98 | |
| 248_R | 251_D | 1.167 | 0.97 | |
| 204_L | 223_T | 1.166 | 0.97 | |
| 171_A | 175_A | 1.163 | 0.97 | |
| 278_Q | 282_S | 1.159 | 0.97 | |
| 279_S | 282_S | 1.157 | 0.97 | |
| 249_R | 273_W | 1.13 | 0.97 | |
| 76_Q | 79_G | 1.13 | 0.97 | |
| 285_F | 291_M | 1.122 | 0.97 | |
| 256_A | 269_I | 1.105 | 0.96 | |
| 259_H | 262_D | 1.104 | 0.96 | |
| 248_R | 252_F | 1.099 | 0.96 | |
| 194_R | 236_D | 1.084 | 0.96 | |
| 246_R | 284_V | 1.082 | 0.96 | |
| 74_V | 118_S | 1.079 | 0.95 | |
| 218_W | 221_G | 1.071 | 0.95 | |
| 254_A | 258_R | 1.066 | 0.95 | |
| 73_T | 99_L | 1.063 | 0.95 | |
| 226_S | 229_S | 1.053 | 0.95 | |
| 210_R | 252_F | 1.05 | 0.94 | |
| 231_Y | 241_V | 1.047 | 0.94 | |
| 269_I | 273_W | 1.046 | 0.94 | |
| 84_E | 109_Y | 1.042 | 0.94 | |
| 210_R | 272_H | 1.033 | 0.94 | |
| 209_I | 245_I | 1.03 | 0.94 | |
| 81_A | 92_I | 1.027 | 0.94 | |
| 243_Q | 246_R | 1.017 | 0.93 | |
| 284_V | 287_Q | 1.012 | 0.93 | |
| 208_N | 222_E | 1.011 | 0.93 | |
| 216_P | 227_V | 1.002 | 0.92 | |
| 171_A | 174_Q | 1.001 | 0.92 | |
| 254_A | 285_F | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.8405 | 100 | 0.32 | Contact Map | 0.653 |
| 3oouA | 1 | 0.3555 | 100 | 0.51 | Contact Map | 0.766 |
| 3oioA | 1 | 0.3621 | 99.9 | 0.514 | Contact Map | 0.782 |
| 3mn2A | 2 | 0.3455 | 99.9 | 0.515 | Contact Map | 0.747 |
| 3mklA | 2 | 0.3621 | 99.9 | 0.515 | Contact Map | 0.78 |
| 1bl0A | 1 | 0.3754 | 99.9 | 0.518 | Contact Map | 0.704 |
| 2k9sA | 1 | 0.3522 | 99.9 | 0.519 | Contact Map | 0.555 |
| 3w6vA | 1 | 0.4551 | 99.9 | 0.527 | Contact Map | 0.772 |
| 3lsgA | 5 | 0.3389 | 99.9 | 0.53 | Contact Map | 0.865 |
| 1d5yA | 4 | 0.3488 | 99.9 | 0.534 | Contact Map | 0.661 |
Sequence Conservation (Image Generated using WebLogo v3)