| UniProt: | P76241 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13499 | ||
| Length: | 273 (229) | ||
| Sequences: | 11993 | ||
| Seq/Len: | 52.37 |
| YEAM
Paralog alert: 0.75 [within 20: 0.20] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 212_L | 248_L | 3.26 | 1.00 | |
| 170_G | 173_E | 3.045 | 1.00 | |
| 223_D | 231_T | 3.023 | 1.00 | |
| 201_L | 209_Q | 3.019 | 1.00 | |
| 178_G | 188_E | 3.006 | 1.00 | |
| 166_M | 170_G | 2.979 | 1.00 | |
| 168_A | 210_L | 2.896 | 1.00 | |
| 216_L | 248_L | 2.842 | 1.00 | |
| 214_M | 217_Q | 2.81 | 1.00 | |
| 244_F | 255_Y | 2.672 | 1.00 | |
| 215_A | 240_F | 2.349 | 1.00 | |
| 218_G | 231_T | 2.325 | 1.00 | |
| 209_Q | 247_G | 2.26 | 1.00 | |
| 167_M | 207_R | 2.229 | 1.00 | |
| 176_A | 179_Q | 2.157 | 1.00 | |
| 195_I | 206_W | 2.134 | 1.00 | |
| 41_G | 72_G | 2.013 | 1.00 | |
| 218_G | 223_D | 1.987 | 1.00 | |
| 48_H | 85_E | 1.957 | 1.00 | |
| 218_G | 232_L | 1.942 | 1.00 | |
| 219_L | 225_V | 1.937 | 1.00 | |
| 166_M | 183_F | 1.926 | 1.00 | |
| 52_T | 59_L | 1.924 | 1.00 | |
| 212_L | 247_G | 1.895 | 1.00 | |
| 223_D | 227_K | 1.889 | 1.00 | |
| 224_T | 227_K | 1.871 | 1.00 | |
| 50_A | 61_M | 1.858 | 1.00 | |
| 163_M | 191_L | 1.854 | 1.00 | |
| 52_T | 61_M | 1.832 | 1.00 | |
| 167_M | 210_L | 1.819 | 1.00 | |
| 214_M | 218_G | 1.797 | 1.00 | |
| 171_P | 210_L | 1.786 | 1.00 | |
| 160_I | 199_T | 1.765 | 1.00 | |
| 133_R | 136_Q | 1.748 | 1.00 | |
| 47_L | 87_C | 1.741 | 1.00 | |
| 63_P | 66_Y | 1.73 | 1.00 | |
| 250_Q | 258_R | 1.695 | 1.00 | |
| 253_G | 257_A | 1.693 | 1.00 | |
| 186_M | 191_L | 1.67 | 1.00 | |
| 204_R | 208_Q | 1.67 | 1.00 | |
| 165_E | 169_K | 1.653 | 1.00 | |
| 163_M | 184_F | 1.627 | 1.00 | |
| 50_A | 63_P | 1.624 | 1.00 | |
| 54_T | 59_L | 1.618 | 1.00 | |
| 226_Q | 237_T | 1.612 | 1.00 | |
| 177_L | 192_A | 1.587 | 1.00 | |
| 227_K | 231_T | 1.583 | 1.00 | |
| 168_A | 206_W | 1.572 | 1.00 | |
| 166_M | 175_G | 1.565 | 1.00 | |
| 180_W | 203_F | 1.529 | 1.00 | |
| 190_N | 194_L | 1.522 | 1.00 | |
| 216_L | 255_Y | 1.504 | 1.00 | |
| 215_A | 232_L | 1.45 | 1.00 | |
| 56_E | 74_V | 1.447 | 1.00 | |
| 250_Q | 254_R | 1.433 | 1.00 | |
| 186_M | 190_N | 1.433 | 1.00 | |
| 164_V | 199_T | 1.427 | 1.00 | |
| 241_I | 251_T | 1.421 | 1.00 | |
| 52_T | 79_Q | 1.409 | 1.00 | |
| 163_M | 180_W | 1.398 | 0.99 | |
| 173_E | 179_Q | 1.395 | 0.99 | |
| 190_N | 193_R | 1.395 | 0.99 | |
| 38_H | 76_H | 1.391 | 0.99 | |
| 217_Q | 221_K | 1.391 | 0.99 | |
| 178_G | 182_G | 1.366 | 0.99 | |
| 227_K | 230_H | 1.366 | 0.99 | |
| 239_A | 243_M | 1.354 | 0.99 | |
| 222_G | 256_I | 1.353 | 0.99 | |
| 202_S | 205_Q | 1.352 | 0.99 | |
| 54_T | 77_S | 1.343 | 0.99 | |
| 188_E | 192_A | 1.34 | 0.99 | |
| 226_Q | 230_H | 1.33 | 0.99 | |
| 228_V | 232_L | 1.327 | 0.99 | |
| 243_M | 246_K | 1.313 | 0.99 | |
| 201_L | 205_Q | 1.31 | 0.99 | |
| 191_L | 203_F | 1.305 | 0.99 | |
| 171_P | 214_M | 1.289 | 0.99 | |
| 189_R | 193_R | 1.287 | 0.99 | |
| 71_P | 74_V | 1.284 | 0.99 | |
| 166_M | 180_W | 1.277 | 0.99 | |
| 237_T | 241_I | 1.255 | 0.99 | |
| 203_F | 207_R | 1.246 | 0.98 | |
| 36_H | 76_H | 1.242 | 0.98 | |
| 42_Q | 76_H | 1.223 | 0.98 | |
| 179_Q | 183_F | 1.221 | 0.98 | |
| 214_M | 232_L | 1.217 | 0.98 | |
| 225_V | 228_V | 1.202 | 0.98 | |
| 241_I | 253_G | 1.201 | 0.98 | |
| 251_T | 254_R | 1.198 | 0.98 | |
| 234_Y | 243_M | 1.195 | 0.98 | |
| 223_D | 228_V | 1.192 | 0.98 | |
| 48_H | 64_P | 1.191 | 0.98 | |
| 133_R | 140_D | 1.188 | 0.98 | |
| 238_T | 241_I | 1.182 | 0.98 | |
| 180_W | 183_F | 1.175 | 0.98 | |
| 210_L | 214_M | 1.174 | 0.98 | |
| 112_R | 116_L | 1.168 | 0.97 | |
| 222_G | 228_V | 1.164 | 0.97 | |
| 159_K | 186_M | 1.164 | 0.97 | |
| 236_S | 242_T | 1.156 | 0.97 | |
| 113_E | 116_L | 1.144 | 0.97 | |
| 113_E | 117_T | 1.137 | 0.97 | |
| 187_S | 190_N | 1.128 | 0.97 | |
| 164_V | 168_A | 1.124 | 0.97 | |
| 159_K | 184_F | 1.087 | 0.96 | |
| 35_V | 75_E | 1.072 | 0.95 | |
| 192_A | 203_F | 1.067 | 0.95 | |
| 47_L | 85_E | 1.066 | 0.95 | |
| 209_Q | 213_I | 1.066 | 0.95 | |
| 38_H | 42_Q | 1.061 | 0.95 | |
| 211_Q | 232_L | 1.05 | 0.94 | |
| 242_T | 246_K | 1.046 | 0.94 | |
| 136_Q | 140_D | 1.045 | 0.94 | |
| 172_V | 214_M | 1.045 | 0.94 | |
| 179_Q | 182_G | 1.042 | 0.94 | |
| 177_L | 203_F | 1.032 | 0.94 | |
| 228_V | 256_I | 1.026 | 0.94 | |
| 210_L | 213_I | 1.024 | 0.93 | |
| 241_I | 245_K | 1.024 | 0.93 | |
| 51_I | 62_V | 1.008 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9158 | 100 | 0.341 | Contact Map | 0.643 |
| 3oioA | 1 | 0.4103 | 100 | 0.538 | Contact Map | 0.786 |
| 3oouA | 1 | 0.3919 | 100 | 0.54 | Contact Map | 0.784 |
| 3mn2A | 2 | 0.3846 | 99.9 | 0.547 | Contact Map | 0.764 |
| 2k9sA | 1 | 0.3846 | 99.9 | 0.549 | Contact Map | 0.541 |
| 1bl0A | 1 | 0.4615 | 99.9 | 0.549 | Contact Map | 0.742 |
| 3w6vA | 1 | 0.5201 | 99.9 | 0.552 | Contact Map | 0.76 |
| 4fe7A | 1 | 0.9231 | 99.9 | 0.554 | Contact Map | 0.786 |
| 3mklA | 2 | 0.4322 | 99.9 | 0.555 | Contact Map | 0.808 |
| 3lsgA | 5 | 0.37 | 99.9 | 0.556 | Contact Map | 0.876 |
Sequence Conservation (Image Generated using WebLogo v3)