| UniProt: | P10805 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10268 | ||
| Length: | 253 (240) | ||
| Sequences: | 12007 | ||
| Seq/Len: | 50.03 |
| ENVY
Paralog alert: 0.80 [within 20: 0.30] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 199_M | 236_Y | 3.483 | 1.00 | |
| 154_I | 158_D | 3.221 | 1.00 | |
| 166_R | 176_P | 3.166 | 1.00 | |
| 211_K | 219_L | 3.164 | 1.00 | |
| 156_Q | 197_C | 3.144 | 1.00 | |
| 203_V | 236_Y | 3.05 | 1.00 | |
| 201_Y | 204_Q | 2.984 | 1.00 | |
| 188_T | 196_E | 2.977 | 1.00 | |
| 158_D | 161_H | 2.974 | 1.00 | |
| 232_F | 243_Y | 2.899 | 1.00 | |
| 202_A | 228_F | 2.51 | 1.00 | |
| 196_E | 235_F | 2.402 | 1.00 | |
| 205_M | 219_L | 2.339 | 1.00 | |
| 164_N | 167_I | 2.316 | 1.00 | |
| 183_L | 193_I | 2.311 | 1.00 | |
| 155_I | 194_V | 2.256 | 1.00 | |
| 199_M | 235_F | 2.115 | 1.00 | |
| 19_E | 27_T | 2.086 | 1.00 | |
| 205_M | 211_K | 2.039 | 1.00 | |
| 205_M | 220_C | 2.034 | 1.00 | |
| 206_L | 213_I | 2.031 | 1.00 | |
| 211_K | 215_Q | 2.027 | 1.00 | |
| 212_N | 215_Q | 2.001 | 1.00 | |
| 159_I | 197_C | 1.961 | 1.00 | |
| 155_I | 197_C | 1.956 | 1.00 | |
| 121_L | 124_T | 1.896 | 1.00 | |
| 31_P | 34_Y | 1.872 | 1.00 | |
| 19_E | 29_T | 1.856 | 1.00 | |
| 154_I | 171_S | 1.856 | 1.00 | |
| 191_S | 195_T | 1.852 | 1.00 | |
| 238_L | 246_K | 1.839 | 1.00 | |
| 201_Y | 205_M | 1.837 | 1.00 | |
| 15_E | 52_H | 1.819 | 1.00 | |
| 151_V | 179_L | 1.818 | 1.00 | |
| 165_L | 180_K | 1.783 | 1.00 | |
| 174_L | 179_L | 1.762 | 1.00 | |
| 154_I | 163_W | 1.759 | 1.00 | |
| 21_S | 27_T | 1.732 | 1.00 | |
| 241_L | 245_A | 1.729 | 1.00 | |
| 153_R | 157_S | 1.727 | 1.00 | |
| 14_T | 54_L | 1.71 | 1.00 | |
| 151_V | 172_L | 1.706 | 1.00 | |
| 17_E | 29_T | 1.647 | 1.00 | |
| 203_V | 243_Y | 1.618 | 1.00 | |
| 168_V | 190_Y | 1.609 | 1.00 | |
| 156_Q | 193_I | 1.598 | 1.00 | |
| 202_A | 220_C | 1.589 | 1.00 | |
| 178_L | 182_K | 1.588 | 1.00 | |
| 215_Q | 219_L | 1.547 | 1.00 | |
| 214_T | 225_T | 1.53 | 1.00 | |
| 229_I | 239_T | 1.526 | 1.00 | |
| 23_N | 42_N | 1.525 | 1.00 | |
| 179_L | 190_Y | 1.514 | 1.00 | |
| 227_Y | 231_V | 1.508 | 1.00 | |
| 176_P | 180_K | 1.502 | 1.00 | |
| 209_D | 244_L | 1.466 | 1.00 | |
| 215_Q | 218_Q | 1.464 | 1.00 | |
| 151_V | 168_V | 1.462 | 1.00 | |
| 229_I | 241_L | 1.45 | 1.00 | |
| 39_A | 42_N | 1.447 | 1.00 | |
| 166_R | 170_S | 1.437 | 1.00 | |
| 178_L | 181_K | 1.43 | 1.00 | |
| 225_T | 229_I | 1.418 | 1.00 | |
| 214_T | 218_Q | 1.413 | 1.00 | |
| 174_L | 178_L | 1.409 | 1.00 | |
| 238_L | 242_N | 1.409 | 1.00 | |
| 190_Y | 194_V | 1.407 | 0.99 | |
| 21_S | 46_E | 1.396 | 0.99 | |
| 120_A | 127_S | 1.395 | 0.99 | |
| 161_H | 167_I | 1.391 | 0.99 | |
| 17_E | 31_P | 1.391 | 0.99 | |
| 201_Y | 220_C | 1.384 | 0.99 | |
| 216_V | 220_C | 1.36 | 0.99 | |
| 224_S | 230_S | 1.349 | 0.99 | |
| 9_C | 45_I | 1.347 | 0.99 | |
| 159_I | 201_Y | 1.331 | 0.99 | |
| 197_C | 201_Y | 1.329 | 0.99 | |
| 226_S | 229_I | 1.324 | 0.99 | |
| 152_C | 156_Q | 1.318 | 0.99 | |
| 168_V | 171_S | 1.302 | 0.99 | |
| 165_L | 190_Y | 1.302 | 0.99 | |
| 188_T | 192_Q | 1.29 | 0.99 | |
| 204_Q | 208_M | 1.283 | 0.99 | |
| 154_I | 168_V | 1.28 | 0.99 | |
| 231_V | 234_A | 1.278 | 0.99 | |
| 239_T | 242_N | 1.271 | 0.99 | |
| 222_Y | 231_V | 1.262 | 0.99 | |
| 189_S | 192_Q | 1.261 | 0.99 | |
| 213_I | 216_V | 1.256 | 0.99 | |
| 177_S | 181_K | 1.248 | 0.99 | |
| 230_S | 234_A | 1.245 | 0.98 | |
| 167_I | 171_S | 1.238 | 0.98 | |
| 169_A | 176_P | 1.231 | 0.98 | |
| 180_K | 190_Y | 1.22 | 0.98 | |
| 13_L | 16_K | 1.218 | 0.98 | |
| 175_S | 178_L | 1.209 | 0.98 | |
| 127_S | 131_E | 1.202 | 0.98 | |
| 147_V | 172_L | 1.201 | 0.98 | |
| 197_C | 200_R | 1.171 | 0.98 | |
| 145_S | 186_E | 1.17 | 0.97 | |
| 196_E | 200_R | 1.145 | 0.97 | |
| 147_V | 174_L | 1.129 | 0.97 | |
| 15_E | 32_K | 1.123 | 0.97 | |
| 8_P | 40_C | 1.122 | 0.97 | |
| 211_K | 216_V | 1.115 | 0.96 | |
| 167_I | 170_S | 1.107 | 0.96 | |
| 198_R | 220_C | 1.101 | 0.96 | |
| 30_L | 36_A | 1.096 | 0.96 | |
| 13_L | 18_V | 1.088 | 0.96 | |
| 180_K | 189_S | 1.077 | 0.95 | |
| 34_Y | 89_A | 1.065 | 0.95 | |
| 98_F | 102_A | 1.062 | 0.95 | |
| 124_T | 128_N | 1.056 | 0.95 | |
| 229_I | 233_K | 1.052 | 0.95 | |
| 120_A | 124_T | 1.047 | 0.94 | |
| 195_T | 231_V | 1.046 | 0.94 | |
| 96_E | 128_N | 1.04 | 0.94 | |
| 117_L | 124_T | 1.034 | 0.94 | |
| 160_Q | 219_L | 1.032 | 0.94 | |
| 192_Q | 195_T | 1.027 | 0.94 | |
| 160_Q | 201_Y | 1.027 | 0.94 | |
| 117_L | 121_L | 1.021 | 0.93 | |
| 203_V | 232_F | 1.018 | 0.93 | |
| 209_D | 216_V | 1.017 | 0.93 | |
| 120_A | 123_F | 1.01 | 0.93 | |
| 159_I | 194_V | 1.009 | 0.93 | |
| 216_V | 244_L | 1.008 | 0.93 | |
| 227_Y | 230_S | 1.005 | 0.93 | |
| 163_W | 168_V | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9565 | 100 | 0.223 | Contact Map | 0.635 |
| 3oouA | 1 | 0.4229 | 100 | 0.414 | Contact Map | 0.77 |
| 3oioA | 1 | 0.4427 | 100 | 0.417 | Contact Map | 0.782 |
| 3mn2A | 2 | 0.415 | 100 | 0.418 | Contact Map | 0.75 |
| 1bl0A | 1 | 0.4664 | 99.9 | 0.419 | Contact Map | 0.723 |
| 2k9sA | 1 | 0.415 | 99.9 | 0.427 | Contact Map | 0.561 |
| 3mklA | 2 | 0.4506 | 99.9 | 0.43 | Contact Map | 0.795 |
| 3lsgA | 5 | 0.3992 | 99.9 | 0.437 | Contact Map | 0.868 |
| 3w6vA | 1 | 0.5652 | 99.9 | 0.444 | Contact Map | 0.772 |
| 1d5yA | 4 | 0.4348 | 99.9 | 0.447 | Contact Map | 0.681 |
Sequence Conservation (Image Generated using WebLogo v3)