| UniProt: | P63201 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12242 | ||
| Length: | 242 (235) | ||
| Sequences: | 12605 | ||
| Seq/Len: | 53.64 |
| GADW
Paralog alert: 0.80 [within 20: 0.31] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 189_M | 226_Y | 3.384 | 1.00 | |
| 201_I | 209_K | 3.228 | 1.00 | |
| 148_D | 151_K | 3.127 | 1.00 | |
| 156_R | 166_E | 3.118 | 1.00 | |
| 144_L | 148_D | 3.042 | 1.00 | |
| 178_T | 186_A | 2.967 | 1.00 | |
| 193_R | 226_Y | 2.943 | 1.00 | |
| 191_M | 194_R | 2.854 | 1.00 | |
| 146_S | 187_S | 2.824 | 1.00 | |
| 222_F | 233_F | 2.711 | 1.00 | |
| 192_A | 218_F | 2.422 | 1.00 | |
| 186_A | 225_Y | 2.359 | 1.00 | |
| 195_L | 209_K | 2.296 | 1.00 | |
| 154_Y | 157_D | 2.25 | 1.00 | |
| 145_I | 184_L | 2.232 | 1.00 | |
| 173_L | 183_I | 2.21 | 1.00 | |
| 15_D | 22_K | 2.058 | 1.00 | |
| 201_I | 205_T | 2.026 | 1.00 | |
| 189_M | 225_Y | 2.008 | 1.00 | |
| 195_L | 201_I | 1.994 | 1.00 | |
| 195_L | 210_C | 1.98 | 1.00 | |
| 196_L | 203_L | 1.956 | 1.00 | |
| 202_P | 205_T | 1.937 | 1.00 | |
| 149_I | 187_S | 1.923 | 1.00 | |
| 145_I | 187_S | 1.904 | 1.00 | |
| 15_D | 24_S | 1.876 | 1.00 | |
| 141_V | 169_I | 1.867 | 1.00 | |
| 191_M | 195_L | 1.851 | 1.00 | |
| 112_L | 115_S | 1.821 | 1.00 | |
| 138_S | 176_E | 1.805 | 1.00 | |
| 164_T | 169_I | 1.782 | 1.00 | |
| 144_L | 161_R | 1.777 | 1.00 | |
| 181_S | 185_L | 1.774 | 1.00 | |
| 17_Y | 22_K | 1.754 | 1.00 | |
| 26_H | 29_S | 1.753 | 1.00 | |
| 143_R | 147_F | 1.739 | 1.00 | |
| 13_S | 24_S | 1.737 | 1.00 | |
| 228_V | 236_H | 1.734 | 1.00 | |
| 231_H | 235_Q | 1.73 | 1.00 | |
| 155_L | 170_K | 1.697 | 1.00 | |
| 11_R | 47_D | 1.681 | 1.00 | |
| 10_I | 49_R | 1.659 | 1.00 | |
| 144_L | 153_W | 1.656 | 1.00 | |
| 158_I | 180_F | 1.648 | 1.00 | |
| 141_V | 162_M | 1.642 | 1.00 | |
| 205_T | 209_K | 1.616 | 1.00 | |
| 204_H | 215_T | 1.591 | 1.00 | |
| 168_L | 172_K | 1.573 | 1.00 | |
| 142_E | 176_E | 1.565 | 1.00 | |
| 13_S | 26_H | 1.544 | 1.00 | |
| 192_A | 210_C | 1.544 | 1.00 | |
| 19_E | 37_L | 1.526 | 1.00 | |
| 166_E | 170_K | 1.525 | 1.00 | |
| 193_R | 233_F | 1.519 | 1.00 | |
| 219_I | 229_T | 1.512 | 1.00 | |
| 146_S | 183_I | 1.505 | 1.00 | |
| 168_L | 171_K | 1.489 | 1.00 | |
| 217_Y | 221_T | 1.473 | 1.00 | |
| 141_V | 158_I | 1.471 | 1.00 | |
| 92_T | 96_D | 1.451 | 1.00 | |
| 199_R | 234_A | 1.441 | 1.00 | |
| 34_E | 37_L | 1.423 | 1.00 | |
| 164_T | 168_L | 1.421 | 1.00 | |
| 151_K | 157_D | 1.418 | 1.00 | |
| 156_R | 160_E | 1.418 | 1.00 | |
| 179_C | 182_K | 1.414 | 1.00 | |
| 194_R | 198_L | 1.412 | 1.00 | |
| 180_F | 184_L | 1.408 | 1.00 | |
| 169_I | 180_F | 1.406 | 0.99 | |
| 17_Y | 40_D | 1.405 | 0.99 | |
| 149_I | 191_M | 1.393 | 0.99 | |
| 205_T | 208_E | 1.386 | 0.99 | |
| 111_M | 118_S | 1.38 | 0.99 | |
| 228_V | 232_Q | 1.376 | 0.99 | |
| 191_M | 210_C | 1.374 | 0.99 | |
| 167_S | 171_K | 1.356 | 0.99 | |
| 221_T | 224_Q | 1.353 | 0.99 | |
| 215_T | 219_I | 1.348 | 0.99 | |
| 178_T | 182_K | 1.315 | 0.99 | |
| 15_D | 42_A | 1.296 | 0.99 | |
| 219_I | 231_H | 1.296 | 0.99 | |
| 204_H | 208_E | 1.294 | 0.99 | |
| 206_I | 210_C | 1.288 | 0.99 | |
| 157_D | 161_R | 1.26 | 0.99 | |
| 142_E | 146_S | 1.256 | 0.99 | |
| 214_S | 220_N | 1.246 | 0.98 | |
| 229_T | 232_Q | 1.24 | 0.98 | |
| 216_S | 219_I | 1.239 | 0.98 | |
| 187_S | 191_M | 1.225 | 0.98 | |
| 203_L | 206_I | 1.223 | 0.98 | |
| 201_I | 206_I | 1.207 | 0.98 | |
| 165_S | 168_L | 1.205 | 0.98 | |
| 155_L | 180_F | 1.204 | 0.98 | |
| 220_N | 224_Q | 1.198 | 0.98 | |
| 158_I | 161_R | 1.194 | 0.98 | |
| 137_V | 162_M | 1.193 | 0.98 | |
| 118_S | 122_H | 1.179 | 0.98 | |
| 212_Y | 221_T | 1.178 | 0.98 | |
| 11_R | 27_N | 1.171 | 0.98 | |
| 144_L | 158_I | 1.164 | 0.97 | |
| 170_K | 180_F | 1.134 | 0.97 | |
| 187_S | 190_S | 1.116 | 0.96 | |
| 159_A | 166_E | 1.102 | 0.96 | |
| 108_L | 115_S | 1.097 | 0.96 | |
| 186_A | 190_S | 1.094 | 0.96 | |
| 93_A | 97_S | 1.09 | 0.96 | |
| 185_L | 221_T | 1.075 | 0.95 | |
| 157_D | 160_E | 1.075 | 0.95 | |
| 199_R | 206_I | 1.059 | 0.95 | |
| 137_V | 164_T | 1.056 | 0.95 | |
| 188_R | 210_C | 1.044 | 0.94 | |
| 25_L | 31_L | 1.04 | 0.94 | |
| 219_I | 223_R | 1.028 | 0.94 | |
| 111_M | 115_S | 1.028 | 0.94 | |
| 9_L | 12_R | 1.01 | 0.93 | |
| 150_A | 209_K | 1.008 | 0.93 | |
| 93_A | 96_D | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9876 | 100 | 0.167 | Contact Map | 0.636 |
| 3oouA | 1 | 0.4421 | 99.9 | 0.397 | Contact Map | 0.783 |
| 1bl0A | 1 | 0.4793 | 99.9 | 0.397 | Contact Map | 0.733 |
| 3oioA | 1 | 0.4587 | 99.9 | 0.402 | Contact Map | 0.79 |
| 3mn2A | 2 | 0.4339 | 99.9 | 0.402 | Contact Map | 0.766 |
| 3mklA | 2 | 0.4628 | 99.9 | 0.405 | Contact Map | 0.809 |
| 2k9sA | 1 | 0.4339 | 99.9 | 0.409 | Contact Map | 0.548 |
| 4fe7A | 1 | 0.9298 | 99.9 | 0.414 | Contact Map | 0.773 |
| 3w6vA | 1 | 0.5785 | 99.9 | 0.416 | Contact Map | 0.769 |
| 3lsgA | 5 | 0.4174 | 99.9 | 0.419 | Contact Map | 0.873 |
Sequence Conservation (Image Generated using WebLogo v3)