| UniProt: | P09377 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10843 | ||
| Length: | 278 (249) | ||
| Sequences: | 12575 | ||
| Seq/Len: | 50.50 |
| RHAS
Paralog alert: 0.79 [within 20: 0.29] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 225_L | 262_F | 3.433 | 1.00 | |
| 183_H | 186_D | 3.241 | 1.00 | |
| 237_A | 245_R | 3.187 | 1.00 | |
| 191_D | 201_L | 3.154 | 1.00 | |
| 179_W | 183_H | 3.1 | 1.00 | |
| 214_L | 222_R | 3.038 | 1.00 | |
| 181_E | 223_L | 3.002 | 1.00 | |
| 229_R | 262_F | 2.946 | 1.00 | |
| 227_K | 230_H | 2.924 | 1.00 | |
| 258_F | 269_I | 2.787 | 1.00 | |
| 228_A | 254_F | 2.45 | 1.00 | |
| 231_L | 245_R | 2.419 | 1.00 | |
| 222_R | 261_E | 2.36 | 1.00 | |
| 180_L | 220_L | 2.335 | 1.00 | |
| 208_L | 219_Y | 2.254 | 1.00 | |
| 189_N | 192_A | 2.2 | 1.00 | |
| 231_L | 237_A | 2.075 | 1.00 | |
| 237_A | 241_D | 2.072 | 1.00 | |
| 47_I | 54_P | 2.02 | 1.00 | |
| 225_L | 261_E | 2.001 | 1.00 | |
| 36_H | 67_D | 1.982 | 1.00 | |
| 238_S | 241_D | 1.977 | 1.00 | |
| 232_L | 239_V | 1.975 | 1.00 | |
| 45_T | 56_T | 1.932 | 1.00 | |
| 227_K | 231_L | 1.924 | 1.00 | |
| 47_I | 56_T | 1.918 | 1.00 | |
| 179_W | 196_Q | 1.914 | 1.00 | |
| 231_L | 246_C | 1.877 | 1.00 | |
| 173_L | 212_T | 1.854 | 1.00 | |
| 176_L | 204_L | 1.835 | 1.00 | |
| 184_F | 223_L | 1.831 | 1.00 | |
| 180_L | 223_L | 1.792 | 1.00 | |
| 199_L | 204_L | 1.765 | 1.00 | |
| 149_L | 152_Q | 1.746 | 1.00 | |
| 58_T | 61_T | 1.726 | 1.00 | |
| 267_R | 271_Q | 1.724 | 1.00 | |
| 264_W | 272_G | 1.705 | 1.00 | |
| 178_A | 182_D | 1.697 | 1.00 | |
| 179_W | 188_V | 1.683 | 1.00 | |
| 217_Q | 221_N | 1.681 | 1.00 | |
| 49_V | 54_P | 1.675 | 1.00 | |
| 190_W | 205_H | 1.674 | 1.00 | |
| 176_L | 197_F | 1.667 | 1.00 | |
| 43_H | 80_C | 1.655 | 1.00 | |
| 240_T | 251_S | 1.643 | 1.00 | |
| 45_T | 58_T | 1.641 | 1.00 | |
| 193_V | 216_P | 1.616 | 1.00 | |
| 241_D | 245_R | 1.612 | 1.00 | |
| 229_R | 269_I | 1.591 | 1.00 | |
| 181_E | 219_Y | 1.584 | 1.00 | |
| 203_T | 207_Q | 1.563 | 1.00 | |
| 255_S | 265_S | 1.53 | 1.00 | |
| 203_T | 206_R | 1.519 | 1.00 | |
| 228_A | 246_C | 1.515 | 1.00 | |
| 264_W | 268_D | 1.508 | 1.00 | |
| 186_D | 192_A | 1.505 | 1.00 | |
| 241_D | 244_Y | 1.498 | 1.00 | |
| 33_H | 71_H | 1.488 | 1.00 | |
| 177_L | 212_T | 1.488 | 1.00 | |
| 235_S | 270_R | 1.469 | 1.00 | |
| 191_D | 195_D | 1.455 | 1.00 | |
| 134_Q | 159_K | 1.446 | 1.00 | |
| 51_N | 69_D | 1.445 | 1.00 | |
| 47_I | 74_E | 1.442 | 1.00 | |
| 204_L | 216_P | 1.44 | 1.00 | |
| 201_L | 205_H | 1.433 | 1.00 | |
| 199_L | 203_T | 1.431 | 1.00 | |
| 42_E | 82_T | 1.425 | 1.00 | |
| 49_V | 72_L | 1.424 | 1.00 | |
| 215_T | 218_R | 1.423 | 1.00 | |
| 148_I | 155_L | 1.419 | 1.00 | |
| 240_T | 244_Y | 1.395 | 0.99 | |
| 176_L | 193_V | 1.392 | 0.99 | |
| 125_R | 129_A | 1.386 | 0.99 | |
| 230_H | 234_H | 1.376 | 0.99 | |
| 242_I | 246_C | 1.359 | 0.99 | |
| 184_F | 227_K | 1.344 | 0.99 | |
| 66_R | 69_D | 1.317 | 0.99 | |
| 214_L | 218_R | 1.314 | 0.99 | |
| 255_S | 267_R | 1.313 | 0.99 | |
| 253_H | 257_L | 1.312 | 0.99 | |
| 31_H | 71_H | 1.31 | 0.99 | |
| 216_P | 220_L | 1.303 | 0.99 | |
| 257_L | 260_R | 1.3 | 0.99 | |
| 251_S | 255_S | 1.285 | 0.99 | |
| 202_R | 206_R | 1.276 | 0.99 | |
| 179_W | 193_V | 1.275 | 0.99 | |
| 237_A | 242_I | 1.256 | 0.99 | |
| 192_A | 196_Q | 1.255 | 0.99 | |
| 265_S | 268_D | 1.255 | 0.99 | |
| 61_T | 115_R | 1.248 | 0.99 | |
| 37_E | 71_H | 1.244 | 0.98 | |
| 223_L | 227_K | 1.241 | 0.98 | |
| 252_N | 255_S | 1.24 | 0.98 | |
| 172_R | 197_F | 1.234 | 0.98 | |
| 248_F | 257_L | 1.233 | 0.98 | |
| 43_H | 59_G | 1.218 | 0.98 | |
| 227_K | 246_C | 1.216 | 0.98 | |
| 177_L | 181_E | 1.216 | 0.98 | |
| 145_S | 149_L | 1.212 | 0.98 | |
| 193_V | 196_Q | 1.201 | 0.98 | |
| 239_V | 242_I | 1.174 | 0.98 | |
| 250_D | 256_T | 1.174 | 0.98 | |
| 256_T | 260_R | 1.166 | 0.97 | |
| 205_H | 216_P | 1.141 | 0.97 | |
| 30_E | 70_R | 1.14 | 0.97 | |
| 172_R | 199_L | 1.125 | 0.97 | |
| 224_R | 246_C | 1.123 | 0.97 | |
| 235_S | 242_I | 1.119 | 0.96 | |
| 200_S | 203_T | 1.115 | 0.96 | |
| 148_I | 152_Q | 1.115 | 0.96 | |
| 41_V | 44_G | 1.11 | 0.96 | |
| 138_N | 142_S | 1.108 | 0.96 | |
| 223_L | 226_M | 1.103 | 0.96 | |
| 145_S | 152_Q | 1.09 | 0.96 | |
| 255_S | 259_R | 1.086 | 0.96 | |
| 190_W | 216_P | 1.072 | 0.95 | |
| 222_R | 226_M | 1.071 | 0.95 | |
| 192_A | 195_D | 1.068 | 0.95 | |
| 185_A | 227_K | 1.068 | 0.95 | |
| 33_H | 37_E | 1.065 | 0.95 | |
| 194_A | 201_L | 1.045 | 0.94 | |
| 197_F | 204_L | 1.045 | 0.94 | |
| 170_A | 211_Q | 1.031 | 0.94 | |
| 41_V | 46_G | 1.031 | 0.94 | |
| 152_Q | 156_L | 1.021 | 0.93 | |
| 242_I | 270_R | 1.019 | 0.93 | |
| 185_A | 245_R | 1.008 | 0.93 | |
| 46_G | 57_I | 1.005 | 0.93 | |
| 262_F | 269_I | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9496 | 100 | 0.224 | Contact Map | 0.641 |
| 3oouA | 1 | 0.3885 | 100 | 0.481 | Contact Map | 0.769 |
| 3mn2A | 2 | 0.3813 | 99.9 | 0.484 | Contact Map | 0.753 |
| 1bl0A | 1 | 0.4245 | 99.9 | 0.485 | Contact Map | 0.737 |
| 3oioA | 1 | 0.4065 | 99.9 | 0.487 | Contact Map | 0.792 |
| 3mklA | 2 | 0.4065 | 99.9 | 0.491 | Contact Map | 0.796 |
| 2k9sA | 1 | 0.3813 | 99.9 | 0.492 | Contact Map | 0.543 |
| 3w6vA | 1 | 0.5108 | 99.9 | 0.496 | Contact Map | 0.756 |
| 3lsgA | 5 | 0.3669 | 99.9 | 0.499 | Contact Map | 0.874 |
| 1d5yA | 4 | 0.3957 | 99.9 | 0.504 | Contact Map | 0.698 |
Sequence Conservation (Image Generated using WebLogo v3)