| UniProt: | P33234 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11966 | ||
| Length: | 253 (241) | ||
| Sequences: | 11975 | ||
| Seq/Len: | 49.69 |
| ADIY
Paralog alert: 0.79 [within 20: 0.28] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 199_M | 236_Y | 3.566 | 1.00 | |
| 154_I | 158_D | 3.281 | 1.00 | |
| 211_K | 219_S | 3.202 | 1.00 | |
| 166_S | 176_P | 3.173 | 1.00 | |
| 156_E | 197_C | 3.152 | 1.00 | |
| 158_D | 161_K | 3.052 | 1.00 | |
| 201_Y | 204_N | 3.01 | 1.00 | |
| 203_V | 236_Y | 2.974 | 1.00 | |
| 188_T | 196_T | 2.919 | 1.00 | |
| 232_F | 243_Y | 2.837 | 1.00 | |
| 202_A | 228_F | 2.542 | 1.00 | |
| 196_T | 235_F | 2.395 | 1.00 | |
| 205_E | 219_S | 2.335 | 1.00 | |
| 183_L | 193_I | 2.312 | 1.00 | |
| 164_N | 167_M | 2.306 | 1.00 | |
| 155_I | 194_I | 2.289 | 1.00 | |
| 199_M | 235_F | 2.164 | 1.00 | |
| 19_W | 27_P | 2.093 | 1.00 | |
| 206_L | 213_I | 2.07 | 1.00 | |
| 155_I | 197_C | 2.038 | 1.00 | |
| 205_E | 220_C | 2.034 | 1.00 | |
| 212_N | 215_Q | 2.033 | 1.00 | |
| 205_E | 211_K | 2.031 | 1.00 | |
| 211_K | 215_Q | 1.992 | 1.00 | |
| 159_I | 197_C | 1.932 | 1.00 | |
| 154_I | 171_C | 1.917 | 1.00 | |
| 121_L | 124_T | 1.905 | 1.00 | |
| 201_Y | 205_E | 1.887 | 1.00 | |
| 19_W | 29_S | 1.847 | 1.00 | |
| 191_S | 195_T | 1.832 | 1.00 | |
| 31_K | 34_H | 1.81 | 1.00 | |
| 154_I | 163_W | 1.783 | 1.00 | |
| 238_M | 246_Q | 1.774 | 1.00 | |
| 165_L | 180_K | 1.754 | 1.00 | |
| 174_L | 179_L | 1.746 | 1.00 | |
| 241_L | 245_S | 1.741 | 1.00 | |
| 153_Q | 157_S | 1.734 | 1.00 | |
| 151_V | 179_L | 1.717 | 1.00 | |
| 21_R | 27_P | 1.712 | 1.00 | |
| 14_T | 54_L | 1.66 | 1.00 | |
| 151_V | 172_L | 1.648 | 1.00 | |
| 17_D | 29_S | 1.625 | 1.00 | |
| 202_A | 220_C | 1.621 | 1.00 | |
| 203_V | 243_Y | 1.614 | 1.00 | |
| 168_V | 190_Y | 1.604 | 1.00 | |
| 23_N | 42_N | 1.588 | 1.00 | |
| 215_Q | 219_S | 1.557 | 1.00 | |
| 214_S | 225_T | 1.556 | 1.00 | |
| 178_L | 182_K | 1.55 | 1.00 | |
| 156_E | 193_I | 1.547 | 1.00 | |
| 227_Y | 231_V | 1.541 | 1.00 | |
| 229_I | 239_T | 1.531 | 1.00 | |
| 15_E | 52_N | 1.523 | 1.00 | |
| 151_V | 168_V | 1.514 | 1.00 | |
| 215_Q | 218_Q | 1.479 | 1.00 | |
| 209_D | 244_V | 1.477 | 1.00 | |
| 39_N | 42_N | 1.475 | 1.00 | |
| 176_P | 180_K | 1.466 | 1.00 | |
| 178_L | 181_K | 1.456 | 1.00 | |
| 161_K | 167_M | 1.449 | 1.00 | |
| 179_L | 190_Y | 1.43 | 1.00 | |
| 21_R | 46_D | 1.429 | 1.00 | |
| 224_S | 230_S | 1.42 | 1.00 | |
| 166_S | 170_S | 1.418 | 1.00 | |
| 229_I | 241_L | 1.417 | 1.00 | |
| 17_D | 31_K | 1.415 | 1.00 | |
| 120_A | 127_S | 1.41 | 1.00 | |
| 174_L | 178_L | 1.408 | 1.00 | |
| 214_S | 218_Q | 1.407 | 0.99 | |
| 159_I | 201_Y | 1.397 | 0.99 | |
| 190_Y | 194_I | 1.391 | 0.99 | |
| 216_V | 220_C | 1.391 | 0.99 | |
| 9_C | 45_I | 1.381 | 0.99 | |
| 225_T | 229_I | 1.373 | 0.99 | |
| 238_M | 242_H | 1.363 | 0.99 | |
| 204_N | 208_M | 1.329 | 0.99 | |
| 226_S | 229_I | 1.329 | 0.99 | |
| 201_Y | 220_C | 1.328 | 0.99 | |
| 188_T | 192_Q | 1.306 | 0.99 | |
| 222_Y | 231_V | 1.286 | 0.99 | |
| 154_I | 168_V | 1.282 | 0.99 | |
| 152_Y | 156_E | 1.282 | 0.99 | |
| 213_I | 216_V | 1.28 | 0.99 | |
| 197_C | 201_Y | 1.279 | 0.99 | |
| 231_V | 234_D | 1.279 | 0.99 | |
| 165_L | 190_Y | 1.277 | 0.99 | |
| 168_V | 171_C | 1.273 | 0.99 | |
| 177_S | 181_K | 1.252 | 0.99 | |
| 167_M | 171_C | 1.246 | 0.98 | |
| 127_S | 131_D | 1.243 | 0.98 | |
| 189_S | 192_Q | 1.241 | 0.98 | |
| 239_T | 242_H | 1.23 | 0.98 | |
| 196_T | 200_R | 1.191 | 0.98 | |
| 34_H | 89_T | 1.19 | 0.98 | |
| 98_F | 102_A | 1.183 | 0.98 | |
| 169_A | 176_P | 1.176 | 0.98 | |
| 180_K | 190_Y | 1.164 | 0.97 | |
| 230_S | 234_D | 1.156 | 0.97 | |
| 124_T | 128_R | 1.155 | 0.97 | |
| 175_S | 178_L | 1.155 | 0.97 | |
| 13_L | 16_K | 1.155 | 0.97 | |
| 147_V | 172_L | 1.151 | 0.97 | |
| 198_R | 220_C | 1.148 | 0.97 | |
| 197_C | 200_R | 1.136 | 0.97 | |
| 15_E | 32_A | 1.133 | 0.97 | |
| 145_N | 186_E | 1.114 | 0.96 | |
| 147_V | 174_L | 1.113 | 0.96 | |
| 211_K | 216_V | 1.108 | 0.96 | |
| 13_L | 18_V | 1.088 | 0.96 | |
| 30_L | 36_A | 1.079 | 0.95 | |
| 8_P | 40_C | 1.073 | 0.95 | |
| 167_M | 170_S | 1.071 | 0.95 | |
| 99_R | 102_A | 1.064 | 0.95 | |
| 120_A | 124_T | 1.063 | 0.95 | |
| 159_I | 194_I | 1.058 | 0.95 | |
| 209_D | 216_V | 1.056 | 0.95 | |
| 216_V | 244_V | 1.055 | 0.95 | |
| 195_T | 231_V | 1.05 | 0.94 | |
| 117_R | 121_L | 1.05 | 0.94 | |
| 180_K | 189_S | 1.045 | 0.94 | |
| 236_Y | 243_Y | 1.035 | 0.94 | |
| 229_I | 233_K | 1.028 | 0.94 | |
| 163_W | 168_V | 1.015 | 0.93 | |
| 117_R | 124_T | 1.013 | 0.93 | |
| 160_H | 219_S | 1.011 | 0.93 | |
| 228_F | 240_P | 1.01 | 0.93 | |
| 203_V | 232_F | 1.009 | 0.93 | |
| 160_H | 201_Y | 1.009 | 0.93 | |
| 224_S | 227_Y | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9565 | 100 | 0.18 | Contact Map | 0.639 |
| 3oouA | 1 | 0.4229 | 100 | 0.385 | Contact Map | 0.774 |
| 3oioA | 1 | 0.4427 | 100 | 0.388 | Contact Map | 0.783 |
| 1bl0A | 1 | 0.4664 | 99.9 | 0.391 | Contact Map | 0.721 |
| 3mn2A | 2 | 0.415 | 99.9 | 0.391 | Contact Map | 0.744 |
| 3mklA | 2 | 0.4506 | 99.9 | 0.392 | Contact Map | 0.79 |
| 2k9sA | 1 | 0.415 | 99.9 | 0.4 | Contact Map | 0.561 |
| 3w6vA | 1 | 0.5652 | 99.9 | 0.405 | Contact Map | 0.772 |
| 3lsgA | 5 | 0.3992 | 99.9 | 0.408 | Contact Map | 0.87 |
| 1d5yA | 4 | 0.4348 | 99.9 | 0.418 | Contact Map | 0.682 |
Sequence Conservation (Image Generated using WebLogo v3)