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EUTR - HTH-type transcriptional regulator eutR
UniProt: P36547 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12190
Length: 350 (314)
Sequences: 1875
Seq/Len: 5.97
EUTR
Paralog alert: 0.59 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
300_E 318_W 4.137 1.00
250_L 292_I 4.131 1.00
248_Y 252_N 3.751 1.00
294_L 334_F 3.303 1.00
249_V 289_L 3.293 1.00
330_Y 341_T 3.211 1.00
297_V 318_W 2.826 1.00
78_R 138_T 2.707 1.00
252_N 255_E 2.59 1.00
291_R 333_L 2.572 1.00
245_A 266_L 2.543 1.00
300_E 317_Q 2.422 1.00
277_F 288_W 2.411 1.00
309_M 317_Q 2.331 1.00
295_N 334_F 2.067 1.00
285_P 289_L 2.054 1.00
245_A 273_L 2.042 1.00
296_A 318_W 2.022 1.00
298_R 302_I 1.976 1.00
298_R 336_E 1.959 1.00
98_F 122_T 1.959 1.00
260_L 264_N 1.955 1.00
336_E 344_Q 1.942 1.00
283_I 291_R 1.936 1.00
103_T 138_T 1.894 1.00
245_A 265_Q 1.874 1.00
298_R 334_F 1.859 1.00
249_V 292_I 1.849 1.00
263_C 270_R 1.841 1.00
298_R 341_T 1.839 1.00
272_T 275_N 1.822 1.00
297_V 326_F 1.817 1.00
336_E 341_T 1.806 1.00
296_A 300_E 1.799 1.00
268_V 272_T 1.784 1.00
314_A 342_L 1.772 1.00
284_G 287_A 1.771 1.00
268_V 273_L 1.769 1.00
288_W 292_I 1.752 1.00
270_R 274_Q 1.726 1.00
241_L 268_V 1.725 1.00
310_T 313_D 1.704 1.00
242_L 276_A 1.695 1.00
102_A 140_L 1.691 1.00
296_A 299_R 1.67 1.00
248_Y 266_L 1.638 1.00
322_H 325_Q 1.63 1.00
250_L 288_W 1.569 0.99
248_Y 265_Q 1.544 0.99
325_Q 329_D 1.523 0.99
248_Y 257_V 1.52 0.99
255_E 261_D 1.515 0.99
311_V 314_A 1.508 0.99
312_K 323_L 1.49 0.99
246_R 281_L 1.471 0.99
273_L 285_P 1.461 0.99
290_K 329_D 1.446 0.99
294_L 333_L 1.444 0.99
304_P 342_L 1.442 0.99
246_R 250_L 1.436 0.99
107_Q 132_S 1.403 0.98
271_R 275_N 1.4 0.98
262_L 265_Q 1.393 0.98
109_F 172_L 1.393 0.98
271_R 274_Q 1.387 0.98
301_L 311_V 1.386 0.98
327_A 337_K 1.374 0.98
299_R 303_S 1.372 0.98
253_M 292_I 1.36 0.98
111_G 127_T 1.322 0.97
107_Q 114_C 1.322 0.97
309_M 314_A 1.319 0.97
300_E 309_M 1.305 0.97
315_A 320_F 1.302 0.97
244_R 265_Q 1.3 0.97
187_Q 191_A 1.293 0.97
260_L 270_R 1.292 0.97
109_F 130_E 1.291 0.97
300_E 314_A 1.279 0.96
259_V 274_Q 1.275 0.96
109_F 114_C 1.266 0.96
286_N 289_L 1.25 0.96
249_V 285_P 1.242 0.96
316_M 321_W 1.233 0.95
313_D 317_Q 1.231 0.95
295_N 333_L 1.231 0.95
330_Y 336_E 1.227 0.95
292_I 295_N 1.226 0.95
261_D 265_Q 1.22 0.95
259_V 285_P 1.213 0.95
246_R 288_W 1.213 0.95
283_I 287_A 1.212 0.95
245_A 277_F 1.211 0.95
259_V 270_R 1.206 0.94
253_M 257_V 1.197 0.94
97_W 141_G 1.192 0.94
124_P 127_T 1.192 0.94
291_R 295_N 1.19 0.94
311_V 339_S 1.188 0.94
73_D 210_G 1.184 0.94
94_N 146_E 1.182 0.94
312_K 316_M 1.178 0.94
320_F 326_F 1.173 0.93
101_P 106_E 1.173 0.93
287_A 290_K 1.162 0.93
290_K 325_Q 1.158 0.93
262_L 285_P 1.147 0.92
244_R 266_L 1.145 0.92
37_T 43_H 1.144 0.92
248_Y 262_L 1.139 0.92
309_M 313_D 1.133 0.92
241_L 266_L 1.132 0.92
286_N 290_K 1.131 0.92
238_Y 279_A 1.126 0.91
272_T 276_A 1.123 0.91
297_V 320_F 1.119 0.91
145_S 148_V 1.119 0.91
277_F 285_P 1.092 0.90
37_T 46_T 1.092 0.90
66_F 104_R 1.087 0.89
325_Q 328_T 1.084 0.89
212_N 215_M 1.084 0.89
146_E 150_T 1.076 0.89
34_Q 37_T 1.072 0.88
37_T 40_V 1.07 0.88
294_L 298_R 1.069 0.88
274_Q 286_N 1.067 0.88
40_V 47_I 1.061 0.88
115_L 121_A 1.061 0.88
188_Q 192_T 1.052 0.87
208_V 212_N 1.042 0.87
208_V 215_M 1.035 0.86
51_Q 54_Y 1.022 0.85
242_L 281_L 1.017 0.85
144_L 149_I 1.011 0.84
47_I 52_Q 1.01 0.84
183_W 187_Q 1.009 0.84
247_E 251_E 1.007 0.84
40_V 49_A 1.005 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3gbgA10.75711000.537Contact Map0.672
3oioA10.322999.90.623Contact Map0.809
3mn2A20.308699.90.627Contact Map0.823
3oouA10.308699.90.63Contact Map0.764
1bl0A10.337199.90.631Contact Map0.701
2k9sA10.302999.90.632Contact Map0.548
3mklA20.322999.90.635Contact Map0.765
3lsgA50.291499.90.639Contact Map0.837
3w6vA10.414399.90.642Contact Map0.752
1d5yA40.314399.90.645Contact Map0.667
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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