| UniProt: | P0ACH8 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11230 | ||
| Length: | 302 (259) | ||
| Sequences: | 6918 | ||
| Seq/Len: | 26.71 |
| MELR
Paralog alert: 0.80 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 245_I | 282_V | 4.166 | 1.00 | |
| 203_N | 206_Q | 3.857 | 1.00 | |
| 199_F | 203_N | 3.577 | 1.00 | |
| 201_A | 243_M | 3.257 | 1.00 | |
| 257_K | 265_T | 3.256 | 1.00 | |
| 211_N | 221_A | 3.1 | 1.00 | |
| 249_R | 282_V | 3.063 | 1.00 | |
| 247_H | 250_A | 3.031 | 1.00 | |
| 234_L | 242_A | 2.934 | 1.00 | |
| 248_V | 274_F | 2.862 | 1.00 | |
| 278_F | 289_Y | 2.709 | 1.00 | |
| 252_L | 259_I | 2.638 | 1.00 | |
| 228_F | 239_Y | 2.432 | 1.00 | |
| 58_E | 65_K | 2.431 | 1.00 | |
| 200_I | 243_M | 2.416 | 1.00 | |
| 200_I | 240_I | 2.385 | 1.00 | |
| 245_I | 281_Y | 2.322 | 1.00 | |
| 58_E | 67_N | 2.266 | 1.00 | |
| 209_T | 212_D | 2.245 | 1.00 | |
| 242_A | 281_Y | 2.24 | 1.00 | |
| 47_V | 78_A | 2.234 | 1.00 | |
| 198_G | 202_E | 2.213 | 1.00 | |
| 284_M | 292_L | 2.189 | 1.00 | |
| 42_H | 82_H | 2.183 | 1.00 | |
| 44_H | 82_H | 2.172 | 1.00 | |
| 204_Y | 243_M | 2.171 | 1.00 | |
| 196_M | 224_A | 2.096 | 1.00 | |
| 251_L | 266_A | 2.078 | 1.00 | |
| 251_L | 265_T | 2.021 | 1.00 | |
| 213_V | 236_M | 2.021 | 1.00 | |
| 219_L | 224_A | 1.985 | 1.00 | |
| 287_Q | 291_K | 1.981 | 1.00 | |
| 210_I | 225_M | 1.979 | 1.00 | |
| 255_T | 290_R | 1.953 | 1.00 | |
| 251_L | 257_K | 1.941 | 1.00 | |
| 56_D | 67_N | 1.93 | 1.00 | |
| 237_K | 241_T | 1.927 | 1.00 | |
| 62_N | 80_T | 1.875 | 1.00 | |
| 257_K | 261_D | 1.839 | 1.00 | |
| 60_L | 65_K | 1.808 | 1.00 | |
| 48_E | 82_H | 1.8 | 1.00 | |
| 258_S | 261_D | 1.771 | 1.00 | |
| 196_M | 217_V | 1.759 | 1.00 | |
| 211_N | 215_E | 1.671 | 1.00 | |
| 199_F | 208_L | 1.663 | 1.00 | |
| 56_D | 69_N | 1.661 | 1.00 | |
| 236_M | 240_I | 1.659 | 1.00 | |
| 54_D | 70_Q | 1.638 | 1.00 | |
| 69_N | 72_H | 1.63 | 1.00 | |
| 199_F | 216_H | 1.627 | 1.00 | |
| 193_V | 232_M | 1.619 | 1.00 | |
| 248_V | 266_A | 1.599 | 1.00 | |
| 77_W | 80_T | 1.598 | 1.00 | |
| 261_D | 264_L | 1.578 | 1.00 | |
| 201_A | 239_Y | 1.577 | 1.00 | |
| 261_D | 265_T | 1.564 | 1.00 | |
| 244_R | 266_A | 1.553 | 1.00 | |
| 54_D | 91_Q | 1.552 | 1.00 | |
| 223_Y | 227_I | 1.529 | 1.00 | |
| 247_H | 251_L | 1.517 | 1.00 | |
| 206_Q | 212_D | 1.5 | 1.00 | |
| 44_H | 48_E | 1.499 | 1.00 | |
| 224_A | 236_M | 1.49 | 1.00 | |
| 259_I | 262_I | 1.479 | 1.00 | |
| 204_Y | 247_H | 1.459 | 1.00 | |
| 223_Y | 226_G | 1.446 | 1.00 | |
| 210_I | 236_M | 1.445 | 1.00 | |
| 243_M | 247_H | 1.428 | 1.00 | |
| 221_A | 225_M | 1.427 | 1.00 | |
| 271_S | 275_Y | 1.419 | 1.00 | |
| 260_L | 264_L | 1.418 | 1.00 | |
| 212_D | 215_E | 1.401 | 0.99 | |
| 196_M | 213_V | 1.392 | 0.99 | |
| 192_Y | 219_L | 1.391 | 0.99 | |
| 250_A | 254_D | 1.378 | 0.99 | |
| 41_S | 81_P | 1.374 | 0.99 | |
| 219_L | 223_Y | 1.362 | 0.99 | |
| 284_M | 288_Q | 1.341 | 0.99 | |
| 58_E | 85_T | 1.338 | 0.99 | |
| 262_I | 290_R | 1.332 | 0.99 | |
| 277_T | 280_K | 1.328 | 0.99 | |
| 273_R | 277_T | 1.323 | 0.99 | |
| 197_L | 232_M | 1.32 | 0.99 | |
| 255_T | 262_I | 1.317 | 0.99 | |
| 213_V | 216_H | 1.317 | 0.99 | |
| 225_M | 236_M | 1.305 | 0.99 | |
| 212_D | 216_H | 1.302 | 0.99 | |
| 192_Y | 217_V | 1.297 | 0.99 | |
| 268_F | 277_T | 1.282 | 0.99 | |
| 199_F | 213_V | 1.273 | 0.99 | |
| 220_N | 223_Y | 1.272 | 0.99 | |
| 262_I | 266_A | 1.266 | 0.99 | |
| 275_Y | 287_Q | 1.26 | 0.99 | |
| 275_Y | 285_S | 1.253 | 0.99 | |
| 252_L | 290_R | 1.252 | 0.99 | |
| 51_V | 73_I | 1.239 | 0.98 | |
| 270_S | 276_S | 1.237 | 0.98 | |
| 53_F | 94_A | 1.225 | 0.98 | |
| 247_H | 266_A | 1.218 | 0.98 | |
| 195_Q | 217_V | 1.209 | 0.98 | |
| 60_L | 83_Q | 1.208 | 0.98 | |
| 200_I | 208_L | 1.189 | 0.98 | |
| 245_I | 277_T | 1.173 | 0.98 | |
| 272_S | 275_Y | 1.165 | 0.97 | |
| 222_N | 226_G | 1.16 | 0.97 | |
| 249_R | 289_Y | 1.152 | 0.97 | |
| 252_L | 262_I | 1.145 | 0.97 | |
| 234_L | 238_Q | 1.138 | 0.97 | |
| 217_V | 224_A | 1.131 | 0.97 | |
| 52_P | 55_G | 1.124 | 0.97 | |
| 274_F | 286_P | 1.111 | 0.96 | |
| 235_T | 238_Q | 1.11 | 0.96 | |
| 260_L | 271_S | 1.105 | 0.96 | |
| 208_L | 213_V | 1.089 | 0.96 | |
| 285_S | 288_Q | 1.089 | 0.96 | |
| 200_I | 239_Y | 1.089 | 0.96 | |
| 273_R | 276_S | 1.086 | 0.96 | |
| 197_L | 239_Y | 1.077 | 0.95 | |
| 225_M | 235_T | 1.072 | 0.95 | |
| 204_Y | 244_R | 1.07 | 0.95 | |
| 257_K | 262_I | 1.068 | 0.95 | |
| 52_P | 57_V | 1.067 | 0.95 | |
| 196_M | 216_H | 1.06 | 0.95 | |
| 205_D | 265_T | 1.05 | 0.94 | |
| 57_V | 68_I | 1.049 | 0.94 | |
| 190_Q | 231_V | 1.041 | 0.94 | |
| 256_D | 262_I | 1.03 | 0.94 | |
| 59_Y | 74_T | 1.025 | 0.93 | |
| 242_A | 246_N | 1.018 | 0.93 | |
| 203_N | 212_D | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.8576 | 100 | 0.399 | Contact Map | 0.662 |
| 3oioA | 1 | 0.3742 | 100 | 0.565 | Contact Map | 0.783 |
| 1bl0A | 1 | 0.404 | 100 | 0.567 | Contact Map | 0.712 |
| 3oouA | 1 | 0.3576 | 100 | 0.567 | Contact Map | 0.784 |
| 3mn2A | 2 | 0.351 | 100 | 0.57 | Contact Map | 0.754 |
| 3mklA | 2 | 0.3874 | 100 | 0.573 | Contact Map | 0.791 |
| 3w6vA | 1 | 0.4868 | 100 | 0.575 | Contact Map | 0.752 |
| 2k9sA | 1 | 0.351 | 100 | 0.576 | Contact Map | 0.552 |
| 3lsgA | 5 | 0.3377 | 100 | 0.581 | Contact Map | 0.863 |
| 1d5yA | 4 | 0.3775 | 99.9 | 0.594 | Contact Map | 0.692 |
Sequence Conservation (Image Generated using WebLogo v3)