| UniProt: | P37639 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12243 | ||
| Length: | 274 (240) | ||
| Sequences: | 11643 | ||
| Seq/Len: | 48.51 |
| GADX
Paralog alert: 0.75 [within 20: 0.31] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 195_M | 232_Y | 3.573 | 1.00 | |
| 150_V | 154_N | 3.361 | 1.00 | |
| 207_F | 215_S | 3.273 | 1.00 | |
| 162_A | 172_P | 3.242 | 1.00 | |
| 154_N | 157_H | 3.095 | 1.00 | |
| 152_N | 193_C | 3.082 | 1.00 | |
| 197_R | 200_Q | 3.027 | 1.00 | |
| 184_T | 192_E | 3.022 | 1.00 | |
| 228_F | 239_Y | 2.912 | 1.00 | |
| 199_L | 232_Y | 2.885 | 1.00 | |
| 198_A | 224_F | 2.509 | 1.00 | |
| 192_E | 231_Y | 2.378 | 1.00 | |
| 179_L | 189_L | 2.332 | 1.00 | |
| 151_I | 190_L | 2.278 | 1.00 | |
| 201_L | 215_S | 2.256 | 1.00 | |
| 195_M | 231_Y | 2.199 | 1.00 | |
| 160_T | 163_R | 2.19 | 1.00 | |
| 202_I | 209_I | 2.173 | 1.00 | |
| 19_L | 26_Y | 2.051 | 1.00 | |
| 208_S | 211_R | 2.014 | 1.00 | |
| 151_I | 193_C | 1.985 | 1.00 | |
| 201_L | 207_F | 1.983 | 1.00 | |
| 201_L | 216_C | 1.953 | 1.00 | |
| 8_C | 39_A | 1.947 | 1.00 | |
| 207_F | 211_R | 1.942 | 1.00 | |
| 234_M | 242_R | 1.935 | 1.00 | |
| 197_R | 201_L | 1.901 | 1.00 | |
| 155_I | 193_C | 1.888 | 1.00 | |
| 237_T | 241_E | 1.862 | 1.00 | |
| 147_V | 175_L | 1.825 | 1.00 | |
| 149_T | 153_N | 1.81 | 1.00 | |
| 19_L | 28_Y | 1.807 | 1.00 | |
| 30_N | 33_D | 1.786 | 1.00 | |
| 150_V | 167_E | 1.777 | 1.00 | |
| 21_M | 26_Y | 1.77 | 1.00 | |
| 161_L | 176_K | 1.727 | 1.00 | |
| 170_M | 175_L | 1.707 | 1.00 | |
| 147_V | 168_L | 1.705 | 1.00 | |
| 187_S | 191_T | 1.694 | 1.00 | |
| 117_L | 120_A | 1.689 | 1.00 | |
| 17_Y | 28_Y | 1.674 | 1.00 | |
| 150_V | 159_W | 1.654 | 1.00 | |
| 164_I | 186_Y | 1.65 | 1.00 | |
| 198_A | 216_C | 1.595 | 1.00 | |
| 205_H | 240_Q | 1.589 | 1.00 | |
| 5_H | 9_L | 1.57 | 1.00 | |
| 152_N | 189_L | 1.553 | 1.00 | |
| 211_R | 215_S | 1.535 | 1.00 | |
| 210_K | 221_V | 1.531 | 1.00 | |
| 17_Y | 30_N | 1.519 | 1.00 | |
| 199_L | 239_Y | 1.501 | 1.00 | |
| 174_L | 178_K | 1.498 | 1.00 | |
| 175_L | 186_Y | 1.482 | 1.00 | |
| 174_L | 177_K | 1.479 | 1.00 | |
| 147_V | 164_I | 1.456 | 1.00 | |
| 223_Y | 227_V | 1.453 | 1.00 | |
| 170_M | 174_L | 1.45 | 1.00 | |
| 38_D | 41_Q | 1.45 | 1.00 | |
| 225_I | 235_T | 1.448 | 1.00 | |
| 23_N | 41_Q | 1.428 | 1.00 | |
| 234_M | 238_E | 1.427 | 1.00 | |
| 211_R | 214_V | 1.426 | 1.00 | |
| 162_A | 166_S | 1.425 | 1.00 | |
| 210_K | 214_V | 1.415 | 1.00 | |
| 172_P | 176_K | 1.414 | 1.00 | |
| 186_Y | 190_L | 1.409 | 1.00 | |
| 184_T | 188_Q | 1.401 | 0.99 | |
| 157_H | 163_R | 1.399 | 0.99 | |
| 200_Q | 204_I | 1.377 | 0.99 | |
| 185_S | 188_Q | 1.376 | 0.99 | |
| 155_I | 197_R | 1.361 | 0.99 | |
| 225_I | 237_T | 1.353 | 0.99 | |
| 193_C | 197_R | 1.35 | 0.99 | |
| 227_V | 230_N | 1.344 | 0.99 | |
| 15_H | 31_G | 1.343 | 0.99 | |
| 222_S | 225_I | 1.333 | 0.99 | |
| 212_V | 216_C | 1.331 | 0.99 | |
| 221_V | 225_I | 1.329 | 0.99 | |
| 197_R | 216_C | 1.329 | 0.99 | |
| 164_I | 167_E | 1.309 | 0.99 | |
| 150_V | 164_I | 1.306 | 0.99 | |
| 95_Q | 99_Q | 1.296 | 0.99 | |
| 161_L | 186_Y | 1.277 | 0.99 | |
| 220_S | 226_Y | 1.275 | 0.99 | |
| 148_C | 152_N | 1.262 | 0.99 | |
| 143_M | 168_L | 1.26 | 0.99 | |
| 226_Y | 230_N | 1.247 | 0.99 | |
| 173_S | 177_K | 1.241 | 0.98 | |
| 235_T | 238_E | 1.236 | 0.98 | |
| 21_M | 43_R | 1.235 | 0.98 | |
| 209_I | 212_V | 1.224 | 0.98 | |
| 171_S | 174_L | 1.223 | 0.98 | |
| 218_Y | 227_V | 1.2 | 0.98 | |
| 116_A | 123_S | 1.197 | 0.98 | |
| 207_F | 212_V | 1.195 | 0.98 | |
| 19_L | 45_D | 1.173 | 0.98 | |
| 176_K | 186_Y | 1.161 | 0.97 | |
| 163_R | 167_E | 1.157 | 0.97 | |
| 95_Q | 98_A | 1.145 | 0.97 | |
| 143_M | 170_M | 1.143 | 0.97 | |
| 193_C | 196_Q | 1.142 | 0.97 | |
| 194_R | 216_C | 1.14 | 0.97 | |
| 13_A | 18_I | 1.127 | 0.97 | |
| 94_F | 98_A | 1.103 | 0.96 | |
| 212_V | 240_Q | 1.098 | 0.96 | |
| 13_A | 16_K | 1.091 | 0.96 | |
| 205_H | 212_V | 1.085 | 0.96 | |
| 163_R | 166_S | 1.076 | 0.95 | |
| 165_A | 172_P | 1.055 | 0.95 | |
| 141_P | 182_E | 1.05 | 0.94 | |
| 120_A | 124_V | 1.048 | 0.94 | |
| 199_L | 228_F | 1.025 | 0.93 | |
| 192_E | 196_Q | 1.02 | 0.93 | |
| 116_A | 120_A | 1.013 | 0.93 | |
| 176_K | 185_S | 1.011 | 0.93 | |
| 159_W | 164_I | 1.004 | 0.93 | |
| 29_F | 35_V | 1.003 | 0.93 | |
| 225_I | 229_R | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.8796 | 100 | 0.314 | Contact Map | 0.657 |
| 3mklA | 2 | 0.438 | 100 | 0.497 | Contact Map | 0.806 |
| 3oouA | 1 | 0.3905 | 100 | 0.505 | Contact Map | 0.776 |
| 3oioA | 1 | 0.4088 | 100 | 0.507 | Contact Map | 0.788 |
| 3mn2A | 2 | 0.3832 | 99.9 | 0.51 | Contact Map | 0.759 |
| 1bl0A | 1 | 0.4672 | 99.9 | 0.514 | Contact Map | 0.724 |
| 2k9sA | 1 | 0.3832 | 99.9 | 0.515 | Contact Map | 0.561 |
| 3w6vA | 1 | 0.5255 | 99.9 | 0.516 | Contact Map | 0.77 |
| 3lsgA | 5 | 0.3686 | 99.9 | 0.522 | Contact Map | 0.872 |
| 4fe7A | 1 | 0.8248 | 99.9 | 0.532 | Contact Map | 0.797 |
Sequence Conservation (Image Generated using WebLogo v3)