| UniProt: | P17410 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10143 | ||
| Length: | 280 (240) | ||
| Sequences: | 12061 | ||
| Seq/Len: | 50.25 |
| CHBR
Paralog alert: 0.74 [within 20: 0.21] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 227_I | 264_T | 3.414 | 1.00 | |
| 193_E | 203_Q | 3.162 | 1.00 | |
| 239_Y | 247_E | 3.139 | 1.00 | |
| 216_K | 224_E | 3.128 | 1.00 | |
| 180_K | 184_K | 3.099 | 1.00 | |
| 184_K | 189_E | 3.098 | 1.00 | |
| 231_K | 264_T | 2.902 | 1.00 | |
| 182_H | 225_I | 2.842 | 1.00 | |
| 229_F | 232_K | 2.839 | 1.00 | |
| 260_F | 271_Y | 2.744 | 1.00 | |
| 233_Q | 247_E | 2.414 | 1.00 | |
| 230_A | 256_F | 2.413 | 1.00 | |
| 224_E | 263_L | 2.392 | 1.00 | |
| 181_M | 222_I | 2.378 | 1.00 | |
| 210_T | 221_I | 2.259 | 1.00 | |
| 191_A | 194_N | 2.258 | 1.00 | |
| 56_F | 63_R | 2.152 | 1.00 | |
| 233_Q | 239_Y | 2.083 | 1.00 | |
| 239_Y | 243_D | 2.068 | 1.00 | |
| 54_R | 65_L | 2.063 | 1.00 | |
| 234_L | 241_V | 2.041 | 1.00 | |
| 227_I | 263_L | 2.037 | 1.00 | |
| 240_S | 243_D | 1.973 | 1.00 | |
| 177_T | 206_L | 1.952 | 1.00 | |
| 56_F | 65_L | 1.939 | 1.00 | |
| 233_Q | 248_A | 1.924 | 1.00 | |
| 187_F | 225_I | 1.901 | 1.00 | |
| 181_M | 225_I | 1.891 | 1.00 | |
| 229_F | 233_Q | 1.867 | 1.00 | |
| 45_Y | 76_L | 1.864 | 1.00 | |
| 180_K | 198_L | 1.837 | 1.00 | |
| 201_K | 206_L | 1.814 | 1.00 | |
| 174_L | 214_Y | 1.756 | 1.00 | |
| 58_E | 63_R | 1.748 | 1.00 | |
| 269_K | 273_K | 1.743 | 1.00 | |
| 219_M | 223_N | 1.739 | 1.00 | |
| 266_F | 274_K | 1.72 | 1.00 | |
| 67_E | 70_D | 1.706 | 1.00 | |
| 192_L | 207_T | 1.699 | 1.00 | |
| 179_E | 183_D | 1.692 | 1.00 | |
| 54_R | 67_E | 1.684 | 1.00 | |
| 242_T | 253_P | 1.677 | 1.00 | |
| 195_M | 218_P | 1.67 | 1.00 | |
| 177_T | 199_S | 1.663 | 1.00 | |
| 243_D | 247_E | 1.623 | 1.00 | |
| 52_T | 90_R | 1.6 | 1.00 | |
| 231_K | 271_Y | 1.597 | 1.00 | |
| 182_H | 221_I | 1.587 | 1.00 | |
| 205_Y | 209_A | 1.559 | 1.00 | |
| 178_V | 214_Y | 1.555 | 1.00 | |
| 230_A | 248_A | 1.553 | 1.00 | |
| 51_L | 92_L | 1.516 | 1.00 | |
| 257_I | 267_T | 1.504 | 1.00 | |
| 189_E | 194_N | 1.503 | 1.00 | |
| 205_Y | 208_R | 1.489 | 1.00 | |
| 266_F | 270_S | 1.473 | 1.00 | |
| 201_K | 205_Y | 1.472 | 1.00 | |
| 243_D | 246_F | 1.468 | 1.00 | |
| 42_H | 80_H | 1.459 | 1.00 | |
| 217_T | 220_Q | 1.456 | 1.00 | |
| 193_E | 197_A | 1.448 | 1.00 | |
| 203_Q | 207_T | 1.437 | 1.00 | |
| 60_N | 78_S | 1.422 | 1.00 | |
| 237_T | 272_R | 1.422 | 1.00 | |
| 232_K | 236_M | 1.42 | 1.00 | |
| 177_T | 195_M | 1.413 | 1.00 | |
| 206_L | 218_P | 1.412 | 1.00 | |
| 242_T | 246_F | 1.412 | 1.00 | |
| 218_P | 222_I | 1.391 | 0.99 | |
| 216_K | 220_Q | 1.389 | 0.99 | |
| 204_E | 208_R | 1.389 | 0.99 | |
| 184_K | 188_S | 1.375 | 0.99 | |
| 56_F | 83_F | 1.375 | 0.99 | |
| 244_I | 248_A | 1.361 | 0.99 | |
| 229_F | 248_A | 1.354 | 0.99 | |
| 58_E | 81_Q | 1.344 | 0.99 | |
| 187_F | 229_F | 1.341 | 0.99 | |
| 259_T | 262_K | 1.328 | 0.99 | |
| 253_P | 257_I | 1.327 | 0.99 | |
| 255_L | 259_T | 1.323 | 0.99 | |
| 150_V | 153_Y | 1.306 | 0.99 | |
| 194_N | 198_L | 1.3 | 0.99 | |
| 257_I | 269_K | 1.291 | 0.99 | |
| 254_S | 257_I | 1.281 | 0.99 | |
| 180_K | 195_M | 1.277 | 0.99 | |
| 267_T | 270_S | 1.255 | 0.99 | |
| 250_Y | 259_T | 1.25 | 0.99 | |
| 52_T | 68_R | 1.241 | 0.98 | |
| 126_L | 130_E | 1.236 | 0.98 | |
| 239_Y | 244_I | 1.227 | 0.98 | |
| 225_I | 229_F | 1.226 | 0.98 | |
| 195_M | 198_L | 1.219 | 0.98 | |
| 226_R | 248_A | 1.199 | 0.98 | |
| 75_P | 78_S | 1.199 | 0.98 | |
| 184_K | 187_F | 1.199 | 0.98 | |
| 252_S | 258_K | 1.183 | 0.98 | |
| 241_V | 244_I | 1.18 | 0.98 | |
| 173_W | 201_K | 1.177 | 0.98 | |
| 40_H | 80_H | 1.177 | 0.98 | |
| 46_E | 80_H | 1.173 | 0.98 | |
| 39_L | 79_H | 1.168 | 0.97 | |
| 237_T | 244_I | 1.16 | 0.97 | |
| 127_T | 130_E | 1.157 | 0.97 | |
| 202_S | 205_Y | 1.152 | 0.97 | |
| 178_V | 182_H | 1.15 | 0.97 | |
| 192_L | 218_P | 1.124 | 0.97 | |
| 224_E | 228_N | 1.123 | 0.97 | |
| 146_F | 153_Y | 1.116 | 0.96 | |
| 257_I | 261_K | 1.109 | 0.96 | |
| 173_W | 199_S | 1.103 | 0.96 | |
| 258_K | 262_K | 1.092 | 0.96 | |
| 207_T | 218_P | 1.085 | 0.96 | |
| 225_I | 228_N | 1.081 | 0.95 | |
| 42_H | 46_E | 1.058 | 0.95 | |
| 50_V | 53_G | 1.047 | 0.94 | |
| 50_V | 55_Y | 1.037 | 0.94 | |
| 264_T | 271_Y | 1.03 | 0.94 | |
| 196_V | 203_Q | 1.012 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9214 | 100 | 0.292 | Contact Map | 0.66 |
| 3oouA | 1 | 0.3821 | 100 | 0.515 | Contact Map | 0.779 |
| 3mn2A | 2 | 0.375 | 100 | 0.516 | Contact Map | 0.764 |
| 3oioA | 1 | 0.4 | 99.9 | 0.519 | Contact Map | 0.784 |
| 1bl0A | 1 | 0.4179 | 99.9 | 0.52 | Contact Map | 0.737 |
| 2k9sA | 1 | 0.375 | 99.9 | 0.524 | Contact Map | 0.537 |
| 3w6vA | 1 | 0.5143 | 99.9 | 0.528 | Contact Map | 0.764 |
| 3lsgA | 5 | 0.3607 | 99.9 | 0.529 | Contact Map | 0.87 |
| 3mklA | 2 | 0.4 | 99.9 | 0.531 | Contact Map | 0.812 |
| 1d5yA | 4 | 0.3893 | 99.9 | 0.536 | Contact Map | 0.705 |
Sequence Conservation (Image Generated using WebLogo v3)