| UniProt: | P76135 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13797 | ||
| Length: | 253 (232) | ||
| Sequences: | 12813 | ||
| Seq/Len: | 55.23 |
| YDEO
Paralog alert: 0.82 [within 20: 0.31] - ratio of genomes with paralogs Cluster includes: ADIY APPY ARAC CHBR ENVY EUTR FEAR GADW GADX MARA MELR RHAR RHAS SOXS YBCM YDEO YDIP YEAM YIDL YIJO YKGD YPDC YQHC |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 187_M | 223_F | 3.297 | 1.00 | |
| 142_I | 146_K | 3.213 | 1.00 | |
| 198_G | 206_Q | 3.107 | 1.00 | |
| 176_T | 184_D | 3.035 | 1.00 | |
| 144_N | 185_A | 3.032 | 1.00 | |
| 191_K | 223_F | 3.016 | 1.00 | |
| 146_K | 149_H | 3.012 | 1.00 | |
| 154_K | 164_E | 2.995 | 1.00 | |
| 189_H | 192_N | 2.834 | 1.00 | |
| 219_F | 230_V | 2.747 | 1.00 | |
| 190_A | 215_F | 2.393 | 1.00 | |
| 184_D | 222_H | 2.321 | 1.00 | |
| 193_L | 206_Q | 2.313 | 1.00 | |
| 143_V | 182_L | 2.29 | 1.00 | |
| 152_K | 155_D | 2.247 | 1.00 | |
| 110_L | 113_S | 2.189 | 1.00 | |
| 171_L | 181_I | 2.15 | 1.00 | |
| 187_M | 222_H | 2.102 | 1.00 | |
| 15_N | 22_D | 2.062 | 1.00 | |
| 198_G | 202_K | 2.046 | 1.00 | |
| 193_L | 198_G | 2.039 | 1.00 | |
| 193_L | 207_C | 1.963 | 1.00 | |
| 194_I | 200_V | 1.955 | 1.00 | |
| 142_I | 159_C | 1.919 | 1.00 | |
| 199_S | 202_K | 1.907 | 1.00 | |
| 15_N | 24_A | 1.893 | 1.00 | |
| 143_V | 185_A | 1.857 | 1.00 | |
| 139_V | 167_L | 1.835 | 1.00 | |
| 189_H | 193_L | 1.83 | 1.00 | |
| 13_A | 24_A | 1.799 | 1.00 | |
| 147_P | 185_A | 1.793 | 1.00 | |
| 11_H | 47_H | 1.784 | 1.00 | |
| 17_N | 22_D | 1.76 | 1.00 | |
| 225_N | 233_E | 1.736 | 1.00 | |
| 26_S | 29_E | 1.725 | 1.00 | |
| 162_I | 167_L | 1.707 | 1.00 | |
| 153_L | 168_K | 1.668 | 1.00 | |
| 141_N | 145_M | 1.665 | 1.00 | |
| 179_S | 183_L | 1.664 | 1.00 | |
| 142_I | 151_W | 1.659 | 1.00 | |
| 139_V | 160_L | 1.627 | 1.00 | |
| 191_K | 230_V | 1.619 | 1.00 | |
| 228_K | 232_K | 1.61 | 1.00 | |
| 10_I | 49_K | 1.602 | 1.00 | |
| 144_N | 181_I | 1.6 | 1.00 | |
| 197_E | 231_S | 1.594 | 1.00 | |
| 201_N | 212_T | 1.592 | 1.00 | |
| 202_K | 206_Q | 1.573 | 1.00 | |
| 156_I | 178_F | 1.567 | 1.00 | |
| 13_A | 26_S | 1.531 | 1.00 | |
| 166_L | 170_K | 1.504 | 1.00 | |
| 216_I | 226_S | 1.491 | 1.00 | |
| 166_L | 169_K | 1.489 | 1.00 | |
| 190_A | 207_C | 1.484 | 1.00 | |
| 192_N | 196_V | 1.47 | 1.00 | |
| 162_I | 166_L | 1.464 | 1.00 | |
| 139_V | 156_I | 1.455 | 1.00 | |
| 19_L | 37_V | 1.448 | 1.00 | |
| 164_E | 168_K | 1.447 | 1.00 | |
| 202_K | 205_E | 1.431 | 1.00 | |
| 225_N | 229_R | 1.417 | 1.00 | |
| 214_Y | 218_A | 1.41 | 1.00 | |
| 149_H | 155_D | 1.409 | 1.00 | |
| 34_D | 37_V | 1.405 | 0.99 | |
| 17_N | 40_H | 1.403 | 0.99 | |
| 109_L | 116_S | 1.392 | 0.99 | |
| 154_K | 158_D | 1.371 | 0.99 | |
| 167_L | 178_F | 1.364 | 0.99 | |
| 218_A | 221_K | 1.355 | 0.99 | |
| 212_T | 216_I | 1.352 | 0.99 | |
| 177_T | 180_Q | 1.348 | 0.99 | |
| 203_I | 207_C | 1.347 | 0.99 | |
| 176_T | 180_Q | 1.342 | 0.99 | |
| 178_F | 182_L | 1.334 | 0.99 | |
| 147_P | 189_H | 1.323 | 0.99 | |
| 15_N | 42_E | 1.317 | 0.99 | |
| 197_E | 203_I | 1.314 | 0.99 | |
| 216_I | 228_K | 1.311 | 0.99 | |
| 140_R | 144_N | 1.307 | 0.99 | |
| 189_H | 207_C | 1.304 | 0.99 | |
| 185_A | 189_H | 1.303 | 0.99 | |
| 165_S | 169_K | 1.301 | 0.99 | |
| 201_N | 205_E | 1.299 | 0.99 | |
| 226_S | 229_R | 1.271 | 0.99 | |
| 211_S | 217_Y | 1.267 | 0.99 | |
| 213_S | 216_I | 1.264 | 0.99 | |
| 200_V | 203_I | 1.257 | 0.99 | |
| 109_L | 113_S | 1.253 | 0.99 | |
| 142_I | 156_I | 1.24 | 0.98 | |
| 155_D | 159_C | 1.238 | 0.98 | |
| 106_F | 110_L | 1.228 | 0.98 | |
| 11_H | 27_D | 1.221 | 0.98 | |
| 116_S | 120_A | 1.214 | 0.98 | |
| 109_L | 112_F | 1.204 | 0.98 | |
| 106_F | 113_S | 1.19 | 0.98 | |
| 209_Y | 218_A | 1.181 | 0.98 | |
| 198_G | 203_I | 1.178 | 0.98 | |
| 156_I | 159_C | 1.171 | 0.98 | |
| 217_Y | 221_K | 1.156 | 0.97 | |
| 168_K | 178_F | 1.145 | 0.97 | |
| 135_V | 160_L | 1.144 | 0.97 | |
| 153_L | 178_F | 1.135 | 0.97 | |
| 135_V | 162_I | 1.127 | 0.97 | |
| 5_C | 39_T | 1.125 | 0.97 | |
| 184_D | 188_Q | 1.123 | 0.97 | |
| 86_T | 90_N | 1.1 | 0.96 | |
| 157_C | 164_E | 1.093 | 0.96 | |
| 163_S | 166_L | 1.088 | 0.96 | |
| 216_I | 220_R | 1.088 | 0.96 | |
| 87_G | 90_N | 1.063 | 0.95 | |
| 185_A | 188_Q | 1.061 | 0.95 | |
| 95_Y | 120_A | 1.055 | 0.95 | |
| 29_E | 80_R | 1.052 | 0.95 | |
| 148_A | 189_H | 1.042 | 0.94 | |
| 186_R | 207_C | 1.026 | 0.94 | |
| 113_S | 117_I | 1.021 | 0.93 | |
| 203_I | 231_S | 1.021 | 0.93 | |
| 155_D | 158_D | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3gbgA | 1 | 0.9368 | 100 | 0.248 | Contact Map | 0.63 |
| 1bl0A | 1 | 0.502 | 100 | 0.456 | Contact Map | 0.726 |
| 3oouA | 1 | 0.419 | 100 | 0.466 | Contact Map | 0.775 |
| 3oioA | 1 | 0.4387 | 99.9 | 0.469 | Contact Map | 0.783 |
| 3mklA | 2 | 0.4704 | 99.9 | 0.473 | Contact Map | 0.804 |
| 3w6vA | 1 | 0.5573 | 99.9 | 0.474 | Contact Map | 0.773 |
| 2k9sA | 1 | 0.4111 | 99.9 | 0.475 | Contact Map | 0.551 |
| 4fe7A | 1 | 0.8814 | 99.9 | 0.476 | Contact Map | 0.792 |
| 3mn2A | 2 | 0.4111 | 99.9 | 0.478 | Contact Map | 0.758 |
| 3lsgA | 5 | 0.3953 | 99.9 | 0.485 | Contact Map | 0.872 |
Sequence Conservation (Image Generated using WebLogo v3)