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YNEJ - Uncharacterized HTH-type transcriptional regulator YneJ
UniProt: P77309 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13818
Length: 293 (286)
Sequences: 37339
Seq/Len: 130.56
YNEJ
Paralog alert: 0.87 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_Q 74_L 3.748 1.00
15_A 24_K 3.424 1.00
156_I 283_D 2.606 1.00
225_V 232_A 2.523 1.00
94_G 139_L 2.448 1.00
20_Q 23_A 2.369 1.00
67_Y 81_V 2.365 1.00
162_E 236_R 2.248 1.00
11_A 24_K 2.229 1.00
14_E 69_Q 2.206 1.00
90_L 119_Q 2.179 1.00
92_S 121_S 2.157 1.00
90_L 121_S 2.134 1.00
71_I 75_V 2.121 1.00
176_R 179_Q 2.119 1.00
157_P 160_R 2.102 1.00
13_A 57_L 2.067 1.00
67_Y 74_L 2.047 1.00
160_R 261_T 2.045 1.00
8_M 35_R 2.002 1.00
10_N 65_L 1.997 1.00
45_V 60_A 1.993 1.00
18_I 36_L 1.993 1.00
110_E 285_P 1.987 1.00
65_L 69_Q 1.952 1.00
222_L 242_M 1.93 1.00
11_A 15_A 1.911 1.00
10_N 69_Q 1.897 1.00
10_N 14_E 1.895 1.00
157_P 261_T 1.885 1.00
11_A 14_E 1.867 1.00
8_M 32_L 1.857 1.00
110_E 281_L 1.847 1.00
49_I 56_R 1.843 1.00
64_F 78_A 1.825 1.00
164_M 236_R 1.796 1.00
132_D 136_E 1.794 1.00
171_Y 183_S 1.793 1.00
186_Y 230_G 1.789 1.00
111_F 118_I 1.759 1.00
13_A 65_L 1.75 1.00
226_I 242_M 1.708 1.00
59_P 62_H 1.683 1.00
63_N 81_V 1.675 1.00
184_N 212_I 1.674 1.00
10_N 68_S 1.668 1.00
9_F 65_L 1.659 1.00
14_E 24_K 1.657 1.00
28_V 31_N 1.643 1.00
130_M 142_A 1.641 1.00
167_T 251_W 1.636 1.00
19_T 29_P 1.631 1.00
111_F 278_F 1.619 1.00
17_S 20_Q 1.604 1.00
8_M 27_R 1.597 1.00
15_A 20_Q 1.591 1.00
10_N 72_L 1.555 1.00
160_R 259_W 1.508 1.00
226_I 247_Q 1.499 1.00
67_Y 77_E 1.496 1.00
133_G 138_K 1.469 1.00
155_G 263_W 1.46 1.00
5_Q 38_Q 1.457 1.00
101_A 219_H 1.455 1.00
11_A 25_V 1.454 1.00
71_I 78_A 1.449 1.00
46_D 49_I 1.442 1.00
183_S 231_I 1.429 1.00
110_E 114_R 1.413 1.00
5_Q 35_R 1.412 1.00
186_Y 221_M 1.408 1.00
64_F 79_R 1.403 0.99
62_H 66_R 1.401 0.99
5_Q 42_E 1.39 0.99
3_L 75_V 1.389 0.99
2_D 5_Q 1.384 0.99
243_P 246_H 1.384 0.99
195_R 199_E 1.371 0.99
88_Q 117_K 1.343 0.99
67_Y 70_Q 1.342 0.99
37_R 41_T 1.332 0.99
264_L 279_I 1.329 0.99
154_D 266_W 1.329 0.99
167_T 231_I 1.318 0.99
110_E 113_R 1.316 0.99
125_G 129_T 1.309 0.99
221_M 232_A 1.308 0.99
154_D 268_R 1.303 0.99
277_A 280_Q 1.297 0.99
279_I 283_D 1.279 0.99
133_G 139_L 1.278 0.99
109_A 113_R 1.269 0.99
34_T 37_R 1.261 0.99
9_F 13_A 1.259 0.99
156_I 266_W 1.251 0.99
134_V 142_A 1.251 0.99
215_M 221_M 1.25 0.99
42_E 79_R 1.247 0.99
66_R 70_Q 1.229 0.98
141_A 264_L 1.228 0.98
111_F 281_L 1.223 0.98
12_V 36_L 1.221 0.98
169_Q 247_Q 1.217 0.98
91_F 278_F 1.214 0.98
172_A 183_S 1.213 0.98
67_Y 78_A 1.212 0.98
92_S 123_S 1.211 0.98
27_R 31_N 1.209 0.98
223_A 226_I 1.204 0.98
9_F 48_F 1.202 0.98
114_R 281_L 1.193 0.98
63_N 66_R 1.19 0.98
112_N 184_N 1.188 0.98
33_T 37_R 1.185 0.98
9_F 47_L 1.184 0.98
51_E 56_R 1.177 0.98
100_A 124_T 1.175 0.98
74_L 77_E 1.174 0.98
12_V 21_A 1.165 0.97
13_A 48_F 1.164 0.97
57_L 61_G 1.163 0.97
135_L 152_A 1.161 0.97
18_I 55_L 1.152 0.97
266_W 279_I 1.151 0.97
144_I 265_V 1.146 0.97
276_E 280_Q 1.134 0.97
112_N 212_I 1.131 0.97
7_E 76_D 1.126 0.97
11_A 21_A 1.123 0.97
236_R 240_E 1.118 0.96
280_Q 283_D 1.117 0.96
168_P 228_G 1.104 0.96
161_E 237_S 1.097 0.96
222_L 226_I 1.096 0.96
267_R 270_A 1.095 0.96
35_R 38_Q 1.094 0.96
63_N 67_Y 1.088 0.96
223_A 227_A 1.084 0.96
239_L 242_M 1.083 0.96
157_P 263_W 1.082 0.96
34_T 38_Q 1.081 0.95
4_T 7_E 1.078 0.95
164_M 250_A 1.078 0.95
6_L 68_S 1.076 0.95
94_G 144_I 1.075 0.95
202_F 207_A 1.075 0.95
114_R 284_V 1.073 0.95
109_A 227_A 1.072 0.95
111_F 115_Y 1.071 0.95
165_I 231_I 1.07 0.95
155_G 265_V 1.068 0.95
27_R 32_L 1.057 0.95
70_Q 77_E 1.057 0.95
115_Y 277_A 1.048 0.94
71_I 74_L 1.042 0.94
76_D 80_S 1.026 0.94
121_S 214_E 1.021 0.93
64_F 68_S 1.02 0.93
48_F 55_L 1.017 0.93
167_T 171_Y 1.015 0.93
146_G 263_W 1.014 0.93
8_M 25_V 1.014 0.93
13_A 61_G 1.01 0.93
79_R 83_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.99321000.088Contact Map0.765
3fxqA211000.095Contact Map0.779
1uthA111000.097Contact Map0.751
1ixcA20.97271000.104Contact Map0.767
3fzvA40.99661000.108Contact Map0.721
1al3A10.99661000.11Contact Map0.76
2h98A20.98291000.113Contact Map0.768
2h9bA20.98981000.12Contact Map0.756
3szpA20.96931000.133Contact Map0.764
3hhgA80.98631000.146Contact Map0.935
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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