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OPENSEQ.org
ILVY - HTH-type transcriptional regulator IlvY
UniProt: P05827 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10503
Length: 297 (292)
Sequences: 37381
Seq/Len: 128.02
ILVY
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_Q 74_Q 3.774 1.00
15_S 24_A 3.424 1.00
233_V 240_A 2.504 1.00
96_F 141_A 2.444 1.00
20_R 23_R 2.398 1.00
67_F 81_T 2.368 1.00
165_A 244_E 2.274 1.00
14_E 69_Q 2.266 1.00
11_H 24_A 2.246 1.00
159_S 294_P 2.206 1.00
184_E 187_D 2.192 1.00
94_H 123_K 2.191 1.00
92_E 121_E 2.168 1.00
92_E 123_K 2.146 1.00
71_T 75_Y 2.131 1.00
160_M 163_N 2.109 1.00
13_A 57_L 2.099 1.00
67_F 74_Q 2.081 1.00
8_T 35_Q 2.016 1.00
10_L 65_R 2.006 1.00
18_F 36_I 1.991 1.00
45_Q 60_A 1.979 1.00
65_R 69_Q 1.971 1.00
163_N 271_E 1.937 1.00
11_H 15_S 1.917 1.00
10_L 69_Q 1.894 1.00
230_V 250_S 1.894 1.00
8_T 32_L 1.885 1.00
10_L 14_E 1.883 1.00
11_H 14_E 1.859 1.00
175_C 191_V 1.854 1.00
194_I 238_G 1.844 1.00
49_V 56_T 1.841 1.00
64_L 78_L 1.841 1.00
112_R 292_I 1.815 1.00
132_A 144_A 1.808 1.00
113_F 120_V 1.801 1.00
234_A 250_S 1.765 1.00
13_A 65_R 1.761 1.00
192_P 220_Y 1.729 1.00
59_E 62_E 1.72 1.00
63_E 81_T 1.696 1.00
14_E 24_A 1.692 1.00
160_M 271_E 1.69 1.00
9_F 65_R 1.684 1.00
10_L 68_A 1.682 1.00
134_E 138_T 1.674 1.00
167_V 244_E 1.666 1.00
19_G 29_P 1.639 1.00
113_F 289_F 1.636 1.00
28_S 31_T 1.628 1.00
8_T 27_V 1.612 1.00
17_H 20_R 1.604 1.00
15_S 20_R 1.604 1.00
88_S 119_S 1.603 1.00
10_L 72_L 1.585 1.00
135_K 140_E 1.55 1.00
170_A 261_L 1.539 1.00
180_Q 187_D 1.528 1.00
234_A 257_R 1.52 1.00
67_F 77_Q 1.509 1.00
194_I 229_M 1.48 1.00
11_H 25_M 1.478 1.00
103_Y 227_E 1.464 1.00
71_T 78_L 1.451 1.00
143_L 286_I 1.449 1.00
5_D 38_R 1.445 1.00
46_P 49_V 1.439 1.00
158_F 273_G 1.435 1.00
5_D 42_D 1.427 1.00
5_D 35_Q 1.415 1.00
64_L 79_R 1.41 1.00
176_P 191_V 1.389 0.99
62_E 66_V 1.388 0.99
191_V 239_V 1.385 0.99
3_L 75_Y 1.384 0.99
163_N 269_P 1.379 0.99
112_R 116_E 1.372 0.99
90_S 119_S 1.361 0.99
2_D 5_D 1.357 0.99
127_G 131_D 1.345 0.99
37_Q 41_E 1.342 0.99
112_R 115_A 1.341 0.99
67_F 70_Q 1.336 0.99
282_H 286_I 1.323 0.99
136_V 144_A 1.311 0.99
229_M 240_A 1.289 0.99
274_V 290_W 1.288 0.99
111_D 115_A 1.287 0.99
223_V 229_M 1.273 0.99
157_A 276_A 1.273 0.99
9_F 13_A 1.266 0.99
157_A 278_K 1.261 0.99
170_A 239_V 1.26 0.99
288_A 291_K 1.254 0.99
114_R 192_P 1.253 0.99
12_L 36_I 1.247 0.99
42_D 79_R 1.245 0.98
135_K 141_A 1.243 0.98
94_H 125_T 1.237 0.98
114_R 220_Y 1.236 0.98
34_R 37_Q 1.232 0.98
113_F 292_I 1.222 0.98
27_V 31_T 1.221 0.98
93_L 289_F 1.22 0.98
167_V 260_I 1.211 0.98
67_F 78_L 1.21 0.98
66_V 70_Q 1.209 0.98
102_A 126_T 1.205 0.98
231_S 234_A 1.205 0.98
260_I 263_R 1.201 0.98
63_E 66_V 1.195 0.98
9_F 48_F 1.193 0.98
51_D 56_T 1.19 0.98
9_F 47_L 1.189 0.98
74_Q 77_Q 1.187 0.98
244_E 248_E 1.182 0.98
33_S 37_Q 1.178 0.98
13_A 48_F 1.174 0.98
248_E 254_V 1.174 0.98
57_L 61_G 1.173 0.98
12_L 21_S 1.173 0.98
7_K 76_Q 1.167 0.97
18_F 55_V 1.155 0.97
137_V 155_A 1.149 0.97
203_R 206_E 1.144 0.97
183_V 187_D 1.142 0.97
159_S 276_A 1.14 0.97
116_E 292_I 1.133 0.97
35_Q 38_R 1.132 0.97
11_H 21_S 1.129 0.97
209_F 214_I 1.128 0.97
230_V 234_A 1.116 0.96
231_S 235_L 1.109 0.96
63_E 67_F 1.105 0.96
287_E 291_K 1.104 0.96
4_R 7_K 1.099 0.96
250_S 257_R 1.096 0.96
164_L 245_V 1.09 0.96
34_R 38_R 1.089 0.96
276_A 290_W 1.087 0.96
143_L 274_V 1.086 0.96
6_L 68_A 1.08 0.95
113_F 117_H 1.078 0.95
111_D 235_L 1.074 0.95
96_F 146_A 1.073 0.95
27_V 32_L 1.07 0.95
177_V 180_Q 1.058 0.95
146_A 275_C 1.056 0.95
70_Q 77_Q 1.051 0.94
71_T 74_Q 1.045 0.94
168_L 239_V 1.042 0.94
48_F 55_V 1.039 0.94
123_K 222_T 1.038 0.94
76_Q 80_H 1.038 0.94
277_Q 280_R 1.036 0.94
117_H 288_A 1.035 0.94
13_A 61_G 1.03 0.94
95_I 143_L 1.025 0.93
64_L 68_A 1.02 0.93
8_T 25_M 1.014 0.93
247_L 251_P 1.008 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1uthA10.97981000.068Contact Map0.734
1al3A10.98321000.071Contact Map0.809
2esnA40.97981000.072Contact Map0.746
3fzvA40.98321000.072Contact Map0.719
2h98A20.96971000.072Contact Map0.753
3fxqA20.97981000.073Contact Map0.774
1ixcA20.97311000.074Contact Map0.755
2h9bA20.96971000.082Contact Map0.741
3szpA20.96971000.101Contact Map0.752
3hhgA80.96971000.114Contact Map0.921
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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