| UniProt: | P0ACR7 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14159 | ||
| Length: | 308 (292) | ||
| Sequences: | 35616 | ||
| Seq/Len: | 121.97 |
| YFER
Paralog alert: 0.88 [within 20: 0.49] - ratio of genomes with paralogs Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 72_R | 76_E | 3.834 | 1.00 | |
| 17_E | 26_R | 3.52 | 1.00 | |
| 233_V | 240_S | 2.567 | 1.00 | |
| 98_A | 143_V | 2.558 | 1.00 | |
| 22_R | 25_E | 2.483 | 1.00 | |
| 160_E | 290_R | 2.412 | 1.00 | |
| 69_R | 83_D | 2.341 | 1.00 | |
| 16_Q | 71_E | 2.329 | 1.00 | |
| 184_P | 187_A | 2.252 | 1.00 | |
| 13_T | 26_R | 2.236 | 1.00 | |
| 96_R | 125_V | 2.236 | 1.00 | |
| 166_P | 244_A | 2.227 | 1.00 | |
| 94_K | 123_Q | 2.216 | 1.00 | |
| 175_S | 191_A | 2.201 | 1.00 | |
| 94_K | 125_V | 2.16 | 1.00 | |
| 15_A | 59_L | 2.152 | 1.00 | |
| 69_R | 76_E | 2.089 | 1.00 | |
| 12_V | 67_A | 2.088 | 1.00 | |
| 10_V | 37_S | 2.076 | 1.00 | |
| 73_L | 77_L | 2.076 | 1.00 | |
| 161_A | 164_S | 2.067 | 1.00 | |
| 20_F | 38_V | 2.054 | 1.00 | |
| 67_A | 71_E | 2.024 | 1.00 | |
| 47_V | 62_A | 2.005 | 1.00 | |
| 13_T | 17_E | 1.974 | 1.00 | |
| 12_V | 71_E | 1.946 | 1.00 | |
| 115_S | 122_I | 1.938 | 1.00 | |
| 164_S | 267_Q | 1.932 | 1.00 | |
| 13_T | 16_Q | 1.93 | 1.00 | |
| 12_V | 16_Q | 1.913 | 1.00 | |
| 10_V | 34_V | 1.9 | 1.00 | |
| 51_D | 58_V | 1.889 | 1.00 | |
| 66_L | 80_T | 1.847 | 1.00 | |
| 134_V | 146_G | 1.846 | 1.00 | |
| 114_E | 292_Q | 1.787 | 1.00 | |
| 15_A | 67_A | 1.774 | 1.00 | |
| 136_E | 140_Q | 1.763 | 1.00 | |
| 114_E | 288_V | 1.762 | 1.00 | |
| 61_D | 64_Q | 1.755 | 1.00 | |
| 168_F | 244_A | 1.749 | 1.00 | |
| 194_V | 238_G | 1.743 | 1.00 | |
| 16_Q | 26_R | 1.735 | 1.00 | |
| 12_V | 70_L | 1.728 | 1.00 | |
| 11_F | 67_A | 1.701 | 1.00 | |
| 21_S | 31_Q | 1.691 | 1.00 | |
| 19_S | 22_R | 1.659 | 1.00 | |
| 161_A | 267_Q | 1.656 | 1.00 | |
| 17_E | 22_R | 1.65 | 1.00 | |
| 30_S | 33_A | 1.649 | 1.00 | |
| 10_V | 29_L | 1.637 | 1.00 | |
| 12_V | 74_L | 1.63 | 1.00 | |
| 137_S | 142_D | 1.627 | 1.00 | |
| 65_Q | 83_D | 1.619 | 1.00 | |
| 115_S | 285_L | 1.611 | 1.00 | |
| 180_E | 187_A | 1.601 | 1.00 | |
| 90_Q | 121_D | 1.564 | 1.00 | |
| 13_T | 27_I | 1.525 | 1.00 | |
| 145_F | 282_A | 1.484 | 1.00 | |
| 7_Q | 37_S | 1.482 | 1.00 | |
| 48_R | 51_D | 1.472 | 1.00 | |
| 73_L | 80_T | 1.47 | 1.00 | |
| 191_A | 239_I | 1.469 | 1.00 | |
| 7_Q | 40_E | 1.468 | 1.00 | |
| 114_E | 118_R | 1.461 | 1.00 | |
| 105_A | 227_A | 1.454 | 1.00 | |
| 69_R | 79_S | 1.449 | 1.00 | |
| 64_Q | 68_L | 1.438 | 1.00 | |
| 39_K | 43_N | 1.403 | 0.99 | |
| 278_L | 282_A | 1.389 | 0.99 | |
| 5_L | 77_L | 1.385 | 0.99 | |
| 194_V | 229_L | 1.383 | 0.99 | |
| 203_R | 207_D | 1.378 | 0.99 | |
| 164_S | 265_E | 1.373 | 0.99 | |
| 114_E | 117_R | 1.372 | 0.99 | |
| 137_S | 143_V | 1.371 | 0.99 | |
| 284_A | 287_D | 1.368 | 0.99 | |
| 92_S | 121_D | 1.365 | 0.99 | |
| 4_S | 7_Q | 1.357 | 0.99 | |
| 7_Q | 44_H | 1.357 | 0.99 | |
| 69_R | 72_R | 1.356 | 0.99 | |
| 171_C | 239_I | 1.356 | 0.99 | |
| 159_C | 269_M | 1.342 | 0.99 | |
| 66_L | 81_L | 1.338 | 0.99 | |
| 129_R | 133_W | 1.336 | 0.99 | |
| 76_E | 79_S | 1.325 | 0.99 | |
| 229_L | 240_S | 1.317 | 0.99 | |
| 113_A | 117_R | 1.313 | 0.99 | |
| 11_F | 15_A | 1.31 | 0.99 | |
| 36_H | 39_K | 1.3 | 0.99 | |
| 270_L | 286_W | 1.298 | 0.99 | |
| 176_A | 191_A | 1.294 | 0.99 | |
| 171_C | 258_K | 1.291 | 0.99 | |
| 192_K | 220_V | 1.275 | 0.99 | |
| 223_I | 229_L | 1.267 | 0.99 | |
| 231_P | 234_A | 1.251 | 0.99 | |
| 14_V | 38_V | 1.25 | 0.99 | |
| 286_W | 290_R | 1.249 | 0.99 | |
| 44_H | 81_L | 1.249 | 0.99 | |
| 68_L | 72_R | 1.248 | 0.99 | |
| 35_S | 39_K | 1.243 | 0.98 | |
| 53_T | 58_V | 1.223 | 0.98 | |
| 11_F | 49_L | 1.223 | 0.98 | |
| 29_L | 33_A | 1.222 | 0.98 | |
| 96_R | 127_H | 1.221 | 0.98 | |
| 158_Q | 272_R | 1.221 | 0.98 | |
| 11_F | 50_L | 1.219 | 0.98 | |
| 65_Q | 68_L | 1.214 | 0.98 | |
| 20_F | 57_V | 1.214 | 0.98 | |
| 15_A | 50_L | 1.209 | 0.98 | |
| 158_Q | 274_K | 1.207 | 0.98 | |
| 139_R | 156_D | 1.206 | 0.98 | |
| 59_L | 63_G | 1.197 | 0.98 | |
| 9_K | 78_N | 1.195 | 0.98 | |
| 115_S | 288_V | 1.195 | 0.98 | |
| 37_S | 40_E | 1.187 | 0.98 | |
| 116_H | 192_K | 1.187 | 0.98 | |
| 95_V | 285_L | 1.182 | 0.98 | |
| 14_V | 23_A | 1.178 | 0.98 | |
| 148_V | 271_V | 1.167 | 0.97 | |
| 160_E | 272_R | 1.166 | 0.97 | |
| 138_I | 146_G | 1.164 | 0.97 | |
| 13_T | 23_A | 1.163 | 0.97 | |
| 210_L | 215_I | 1.16 | 0.97 | |
| 69_R | 80_T | 1.16 | 0.97 | |
| 283_E | 287_D | 1.156 | 0.97 | |
| 287_D | 290_R | 1.151 | 0.97 | |
| 254_P | 260_I | 1.142 | 0.97 | |
| 145_F | 270_L | 1.131 | 0.97 | |
| 172_H | 236_G | 1.126 | 0.97 | |
| 113_A | 235_A | 1.125 | 0.97 | |
| 8_L | 70_L | 1.124 | 0.97 | |
| 115_S | 119_Y | 1.121 | 0.97 | |
| 6_K | 9_K | 1.114 | 0.96 | |
| 65_Q | 69_R | 1.114 | 0.96 | |
| 169_L | 239_I | 1.098 | 0.96 | |
| 98_A | 148_V | 1.089 | 0.96 | |
| 36_H | 40_E | 1.086 | 0.96 | |
| 118_R | 288_V | 1.082 | 0.96 | |
| 50_L | 57_V | 1.072 | 0.95 | |
| 231_P | 235_A | 1.068 | 0.95 | |
| 29_L | 34_V | 1.067 | 0.95 | |
| 272_R | 286_W | 1.065 | 0.95 | |
| 15_A | 63_G | 1.059 | 0.95 | |
| 230_F | 234_A | 1.054 | 0.95 | |
| 119_Y | 284_A | 1.045 | 0.94 | |
| 97_V | 145_F | 1.045 | 0.94 | |
| 10_V | 27_I | 1.038 | 0.94 | |
| 73_L | 76_E | 1.038 | 0.94 | |
| 66_L | 70_L | 1.029 | 0.94 | |
| 165_E | 245_L | 1.023 | 0.93 | |
| 143_V | 146_G | 1.015 | 0.93 | |
| 14_V | 50_L | 1.015 | 0.93 | |
| 129_R | 137_S | 1.014 | 0.93 | |
| 171_C | 175_S | 1.012 | 0.93 | |
| 273_R | 276_R | 1.008 | 0.93 | |
| 192_K | 218_N | 1 | 0.92 | |
| 257_V | 260_I | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3fzvA | 4 | 0.974 | 100 | 0.168 | Contact Map | 0.734 |
| 2esnA | 4 | 0.9643 | 100 | 0.177 | Contact Map | 0.772 |
| 1ixcA | 2 | 0.9448 | 100 | 0.178 | Contact Map | 0.779 |
| 2h98A | 2 | 0.9838 | 100 | 0.183 | Contact Map | 0.81 |
| 1al3A | 1 | 0.9903 | 100 | 0.19 | Contact Map | 0.776 |
| 2h9bA | 2 | 0.9838 | 100 | 0.191 | Contact Map | 0.806 |
| 3fxqA | 2 | 0.9708 | 100 | 0.192 | Contact Map | 0.79 |
| 1uthA | 1 | 0.9773 | 100 | 0.194 | Contact Map | 0.755 |
| 3hhgA | 8 | 0.9805 | 100 | 0.2 | Contact Map | 0.928 |
| 3szpA | 2 | 0.9383 | 100 | 0.203 | Contact Map | 0.762 |
Sequence Conservation (Image Generated using WebLogo v3)