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OPENSEQ.org
HCAR - Hca operon transcriptional activator
UniProt: Q47141 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13455
Length: 296 (288)
Sequences: 37144
Seq/Len: 128.97
HCAR
Paralog alert: 0.86 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_Q 78_A 3.688 1.00
15_A 24_K 3.451 1.00
157_L 288_Q 2.57 1.00
232_V 239_T 2.538 1.00
95_G 140_L 2.381 1.00
20_R 23_E 2.365 1.00
71_I 85_I 2.273 1.00
11_A 24_K 2.214 1.00
163_P 243_G 2.214 1.00
93_T 122_E 2.196 1.00
91_Q 120_L 2.187 1.00
172_H 188_V 2.184 1.00
91_Q 122_E 2.18 1.00
181_T 184_Q 2.179 1.00
158_E 161_D 2.119 1.00
14_Q 73_E 2.103 1.00
13_A 57_L 2.084 1.00
75_A 79_K 2.081 1.00
69_L 73_E 2.041 1.00
45_V 60_A 2.026 1.00
71_I 78_A 2.022 1.00
8_Y 35_Q 1.996 1.00
111_M 290_R 1.994 1.00
18_F 36_I 1.973 1.00
10_V 14_Q 1.931 1.00
11_A 15_A 1.931 1.00
161_D 266_A 1.927 1.00
111_M 286_I 1.855 1.00
11_A 14_Q 1.85 1.00
49_V 56_A 1.844 1.00
8_Y 32_L 1.84 1.00
10_V 69_L 1.825 1.00
165_V 243_G 1.766 1.00
112_F 119_T 1.763 1.00
10_V 73_E 1.753 1.00
233_G 252_Q 1.747 1.00
131_Q 143_G 1.727 1.00
191_V 237_G 1.709 1.00
19_T 29_Q 1.707 1.00
13_A 69_L 1.661 1.00
68_A 82_A 1.653 1.00
168_L 256_R 1.65 1.00
14_Q 24_K 1.649 1.00
112_F 283_F 1.645 1.00
158_E 266_A 1.632 1.00
133_E 137_R 1.627 1.00
15_A 20_R 1.624 1.00
8_Y 27_T 1.612 1.00
17_N 20_R 1.608 1.00
28_S 31_S 1.597 1.00
9_F 69_L 1.583 1.00
67_D 85_I 1.557 1.00
59_A 66_Q 1.555 1.00
87_Q 118_D 1.552 1.00
134_K 139_E 1.526 1.00
177_E 184_Q 1.524 1.00
68_A 83_R 1.502 1.00
161_D 264_S 1.494 1.00
5_H 38_D 1.48 1.00
10_V 72_L 1.474 1.00
46_P 49_V 1.474 1.00
11_A 25_L 1.466 1.00
68_A 72_L 1.464 1.00
66_Q 70_A 1.453 1.00
71_I 81_R 1.446 1.00
5_H 35_Q 1.445 1.00
5_H 42_C 1.442 1.00
102_V 226_L 1.42 1.00
142_V 280_L 1.419 1.00
111_M 115_R 1.407 0.99
70_A 74_Q 1.391 0.99
191_V 228_T 1.39 0.99
188_V 238_V 1.37 0.99
75_A 82_A 1.365 0.99
89_D 118_D 1.364 0.99
202_A 206_K 1.362 0.99
72_L 76_E 1.352 0.99
111_M 114_L 1.346 0.99
67_D 71_I 1.342 0.99
10_V 76_E 1.34 0.99
170_V 252_Q 1.337 0.99
228_T 239_T 1.317 0.99
37_R 41_N 1.315 0.99
2_E 5_H 1.306 0.99
71_I 74_Q 1.304 0.99
282_D 285_A 1.299 0.99
3_L 79_K 1.298 0.99
165_V 255_F 1.296 0.99
168_L 238_V 1.296 0.99
110_P 114_L 1.292 0.99
156_Y 268_L 1.278 0.99
229_M 247_N 1.275 0.99
135_I 143_G 1.272 0.99
9_F 13_A 1.269 0.99
34_S 37_R 1.259 0.99
93_T 124_V 1.255 0.99
126_L 130_Q 1.249 0.99
67_D 70_A 1.248 0.99
222_A 228_T 1.234 0.98
155_D 271_W 1.23 0.98
230_N 233_G 1.228 0.98
134_K 140_L 1.223 0.98
9_F 47_L 1.215 0.98
233_G 247_N 1.214 0.98
71_I 82_A 1.21 0.98
51_D 56_A 1.206 0.98
12_V 36_I 1.206 0.98
284_I 288_Q 1.205 0.98
189_N 219_V 1.202 0.98
9_F 48_L 1.201 0.98
178_K 254_V 1.197 0.98
27_T 31_S 1.196 0.98
173_P 188_V 1.193 0.98
209_F 214_S 1.192 0.98
112_F 286_I 1.192 0.98
113_R 189_N 1.191 0.98
92_L 283_F 1.184 0.98
13_A 48_L 1.177 0.98
136_R 153_E 1.177 0.98
18_F 55_V 1.177 0.98
33_S 37_R 1.164 0.97
101_E 125_S 1.163 0.97
42_C 83_R 1.16 0.97
115_R 286_I 1.159 0.97
269_M 284_I 1.159 0.97
180_I 184_Q 1.159 0.97
276_M 280_L 1.157 0.97
12_V 21_A 1.153 0.97
155_D 273_K 1.152 0.97
57_L 61_G 1.144 0.97
11_A 21_A 1.14 0.97
157_L 271_W 1.137 0.97
229_M 233_G 1.125 0.97
285_A 288_Q 1.114 0.96
34_S 38_D 1.106 0.96
142_V 269_M 1.102 0.96
78_A 81_R 1.101 0.96
110_P 234_M 1.101 0.96
35_Q 38_D 1.1 0.96
4_R 7_R 1.089 0.96
281_R 285_A 1.087 0.96
271_W 284_I 1.087 0.96
95_G 145_M 1.083 0.96
169_P 235_G 1.076 0.95
168_L 172_H 1.076 0.95
112_F 116_Q 1.071 0.95
7_R 80_L 1.07 0.95
230_N 234_M 1.066 0.95
116_Q 282_D 1.062 0.95
27_T 32_L 1.06 0.95
166_V 238_V 1.048 0.94
72_L 75_A 1.046 0.94
6_L 72_L 1.04 0.94
170_V 254_V 1.036 0.94
115_R 289_E 1.03 0.94
48_L 55_V 1.03 0.94
145_M 270_A 1.027 0.94
162_E 244_Y 1.022 0.93
172_H 189_N 1.022 0.93
8_Y 25_L 1.004 0.93
94_I 142_V 1.001 0.92
13_A 61_G 1.001 0.92
172_H 175_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2h98A20.98311000.086Contact Map0.774
1ixcA20.97641000.087Contact Map0.77
2h9bA20.98651000.096Contact Map0.763
2esnA40.97641000.109Contact Map0.765
1al3A10.97971000.11Contact Map0.767
1uthA10.97641000.111Contact Map0.766
3fzvA40.97641000.114Contact Map0.726
3fxqA20.9731000.117Contact Map0.776
3szpA20.95611000.142Contact Map0.765
3hhgA80.96621000.154Contact Map0.922
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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