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YEEY - Uncharacterized HTH-type transcriptional regulator YeeY
UniProt: P76369 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13392
Length: 309 (290)
Sequences: 36674
Seq/Len: 126.46
YEEY
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_E 76_T 3.674 1.00
17_E 26_K 3.346 1.00
162_S 290_L 2.532 1.00
232_Q 239_G 2.461 1.00
98_G 143_A 2.372 1.00
22_A 25_A 2.348 1.00
69_K 83_Q 2.308 1.00
168_E 243_R 2.235 1.00
16_K 71_R 2.197 1.00
187_N 190_I 2.179 1.00
13_A 26_K 2.151 1.00
177_H 194_Y 2.15 1.00
96_V 125_K 2.138 1.00
94_E 123_R 2.133 1.00
94_E 125_K 2.083 1.00
163_R 166_D 2.081 1.00
73_V 77_V 2.071 1.00
166_D 268_P 2.049 1.00
15_E 59_F 2.027 1.00
229_L 249_F 2.001 1.00
69_K 76_T 1.999 1.00
12_D 67_L 1.973 1.00
10_I 37_T 1.95 1.00
20_F 38_V 1.944 1.00
114_A 292_N 1.944 1.00
67_L 71_R 1.909 1.00
47_I 62_T 1.903 1.00
13_A 17_E 1.86 1.00
163_R 268_P 1.857 1.00
12_D 16_K 1.841 1.00
12_D 71_R 1.837 1.00
13_A 16_K 1.836 1.00
51_D 58_K 1.8 1.00
233_I 249_F 1.784 1.00
10_I 34_L 1.778 1.00
114_A 288_E 1.774 1.00
66_L 80_L 1.766 1.00
115_F 122_T 1.76 1.00
170_V 243_R 1.745 1.00
197_I 237_G 1.729 1.00
173_V 258_K 1.714 1.00
15_E 67_L 1.698 1.00
233_I 254_A 1.696 1.00
195_R 219_A 1.676 1.00
65_M 83_Q 1.669 1.00
61_R 64_K 1.656 1.00
134_S 146_I 1.653 1.00
11_L 67_L 1.652 1.00
12_D 70_G 1.645 1.00
16_K 26_K 1.63 1.00
21_A 31_P 1.615 1.00
166_D 266_F 1.597 1.00
115_F 285_W 1.578 1.00
30_T 33_A 1.575 1.00
17_E 22_A 1.573 1.00
170_V 257_E 1.57 1.00
10_I 29_K 1.57 1.00
19_S 22_A 1.565 1.00
136_D 140_Q 1.559 1.00
12_D 74_L 1.555 1.00
90_G 121_V 1.554 1.00
137_A 142_R 1.495 1.00
69_K 79_E 1.48 1.00
161_F 270_W 1.478 1.00
13_A 27_L 1.429 1.00
182_E 190_I 1.425 1.00
105_F 226_K 1.423 1.00
197_I 228_K 1.423 1.00
73_V 80_L 1.416 1.00
48_Q 51_D 1.404 0.99
7_V 37_T 1.403 0.99
7_V 40_K 1.402 0.99
7_V 44_D 1.395 0.99
145_I 282_S 1.389 0.99
5_L 77_V 1.38 0.99
114_A 118_H 1.376 0.99
64_K 68_E 1.361 0.99
66_L 81_E 1.345 0.99
247_Q 251_D 1.335 0.99
173_V 238_C 1.331 0.99
39_H 43_S 1.331 0.99
194_Y 238_C 1.321 0.99
92_E 121_V 1.318 0.99
160_G 275_E 1.311 0.99
160_G 273_W 1.31 0.99
69_K 72_E 1.308 0.99
114_A 117_Q 1.307 0.99
4_L 7_V 1.299 0.99
271_I 286_R 1.286 0.99
228_K 239_G 1.269 0.99
113_E 117_Q 1.267 0.99
249_F 254_A 1.261 0.99
222_V 228_K 1.258 0.99
284_W 287_D 1.255 0.99
138_L 146_I 1.254 0.99
129_G 133_G 1.23 0.98
162_S 273_W 1.229 0.98
184_E 256_I 1.225 0.98
178_P 194_Y 1.224 0.98
14_L 38_V 1.22 0.98
286_R 290_L 1.219 0.98
11_L 15_E 1.202 0.98
137_A 143_A 1.2 0.98
36_Y 39_H 1.2 0.98
44_D 81_E 1.194 0.98
116_Y 195_R 1.194 0.98
115_F 288_E 1.182 0.98
230_E 233_I 1.182 0.98
96_V 127_I 1.179 0.98
68_E 72_E 1.177 0.98
243_R 247_Q 1.175 0.98
11_L 50_L 1.174 0.98
116_Y 219_A 1.173 0.98
145_I 271_I 1.171 0.98
139_T 158_E 1.17 0.97
104_P 128_N 1.168 0.97
95_L 285_W 1.167 0.97
148_G 272_G 1.167 0.97
69_K 80_L 1.165 0.97
118_H 288_E 1.163 0.97
14_L 23_A 1.163 0.97
11_L 49_L 1.161 0.97
257_E 260_V 1.157 0.97
65_M 68_E 1.152 0.97
35_S 39_H 1.152 0.97
9_M 78_R 1.148 0.97
53_S 58_K 1.143 0.97
76_T 79_E 1.143 0.97
186_L 190_I 1.141 0.97
29_K 33_A 1.138 0.97
20_F 57_A 1.136 0.97
15_E 50_L 1.128 0.97
59_F 63_G 1.121 0.97
150_M 270_W 1.121 0.97
175_P 254_A 1.118 0.96
273_W 286_R 1.112 0.96
243_R 257_E 1.106 0.96
13_A 23_A 1.099 0.96
6_D 9_M 1.093 0.96
167_L 244_Y 1.089 0.96
115_F 119_H 1.074 0.95
173_V 177_H 1.069 0.95
174_A 235_G 1.069 0.95
248_R 252_S 1.068 0.95
161_F 272_G 1.063 0.95
37_T 40_K 1.062 0.95
175_P 256_I 1.061 0.95
163_R 270_W 1.061 0.95
177_H 195_R 1.06 0.95
283_G 287_D 1.06 0.95
8_L 70_G 1.055 0.95
171_F 238_C 1.054 0.95
172_A 246_A 1.053 0.95
113_E 234_S 1.053 0.95
287_D 290_L 1.052 0.95
230_E 234_S 1.048 0.94
229_L 233_I 1.048 0.94
36_Y 40_K 1.047 0.94
65_M 69_K 1.047 0.94
78_R 82_K 1.043 0.94
125_K 221_T 1.032 0.94
118_H 291_A 1.031 0.94
29_K 34_L 1.025 0.93
98_G 148_G 1.023 0.93
73_V 76_T 1.023 0.93
72_E 79_E 1.019 0.93
119_H 284_W 1.018 0.93
66_L 70_G 1.006 0.93
50_L 57_A 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.9451000.161Contact Map0.759
3fzvA40.95791000.165Contact Map0.706
3fxqA20.95471000.175Contact Map0.773
1al3A10.98061000.177Contact Map0.755
1uthA10.96121000.178Contact Map0.736
1ixcA20.92561000.179Contact Map0.749
2h98A20.95791000.179Contact Map0.736
3hhgA80.96121000.188Contact Map0.928
2h9bA20.95471000.194Contact Map0.733
3szpA20.92231000.197Contact Map0.773
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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