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OPENSEQ.org
YFIE - Uncharacterized HTH-type transcriptional regulator YfiE
UniProt: P33634 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11785
Length: 293 (290)
Sequences: 38270
Seq/Len: 131.97
YFIE
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_E 74_V 3.643 1.00
15_E 24_K 3.479 1.00
228_V 235_S 2.612 1.00
157_R 287_E 2.598 1.00
20_R 23_Q 2.443 1.00
95_V 140_A 2.406 1.00
163_S 239_R 2.351 1.00
14_E 69_Y 2.293 1.00
11_T 24_K 2.265 1.00
67_H 81_A 2.249 1.00
91_E 120_R 2.249 1.00
93_R 122_S 2.233 1.00
91_E 122_S 2.194 1.00
158_E 161_E 2.149 1.00
71_L 75_M 2.148 1.00
18_F 36_I 2.14 1.00
225_K 245_E 2.107 1.00
13_V 57_L 2.103 1.00
45_V 60_E 2.031 1.00
10_K 65_L 2.03 1.00
111_R 289_S 2.014 1.00
65_L 69_Y 1.983 1.00
8_T 35_H 1.982 1.00
67_H 74_V 1.976 1.00
11_T 15_E 1.967 1.00
10_K 14_E 1.912 1.00
111_R 285_C 1.893 1.00
10_K 69_Y 1.887 1.00
49_E 56_C 1.883 1.00
11_T 14_E 1.881 1.00
112_F 119_V 1.862 1.00
229_A 245_E 1.837 1.00
131_I 143_G 1.822 1.00
165_V 239_R 1.799 1.00
13_V 65_L 1.797 1.00
8_T 32_V 1.774 1.00
229_A 250_E 1.771 1.00
64_L 78_L 1.748 1.00
59_R 62_K 1.735 1.00
133_D 137_N 1.727 1.00
168_A 254_L 1.725 1.00
179_E 182_R 1.707 1.00
10_K 68_I 1.687 1.00
14_E 24_K 1.686 1.00
87_D 118_K 1.68 1.00
9_L 65_L 1.675 1.00
28_T 31_T 1.664 1.00
112_F 282_F 1.663 1.00
15_E 20_R 1.655 1.00
19_L 29_Q 1.642 1.00
17_S 20_R 1.633 1.00
165_V 253_E 1.593 1.00
67_H 77_T 1.565 1.00
10_K 72_T 1.553 1.00
134_A 139_E 1.545 1.00
161_E 262_T 1.54 1.00
8_T 27_C 1.539 1.00
189_I 233_G 1.539 1.00
63_K 81_A 1.511 1.00
11_T 25_L 1.505 1.00
46_Q 49_E 1.495 1.00
142_V 279_M 1.487 1.00
71_L 78_L 1.474 1.00
62_K 66_P 1.445 1.00
102_S 222_E 1.444 1.00
111_R 115_R 1.433 1.00
243_A 247_E 1.424 1.00
161_E 264_T 1.391 0.99
198_R 202_E 1.391 0.99
111_R 114_Q 1.378 0.99
89_D 118_K 1.374 0.99
37_Q 41_Q 1.361 0.99
135_L 143_G 1.357 0.99
126_L 130_V 1.338 0.99
275_V 279_M 1.338 0.99
12_V 36_I 1.334 0.99
5_R 35_H 1.332 0.99
224_I 235_S 1.329 0.99
67_H 70_E 1.322 0.99
281_T 284_Q 1.317 0.99
168_A 234_V 1.314 0.99
3_L 75_M 1.313 0.99
283_I 287_E 1.299 0.99
158_E 264_T 1.29 0.99
245_E 250_E 1.29 0.99
5_R 38_Q 1.289 0.99
110_Q 114_Q 1.284 0.99
2_D 5_R 1.279 0.99
92_L 282_F 1.267 0.99
172_I 186_C 1.267 0.99
134_A 140_A 1.266 0.99
34_F 37_Q 1.266 0.99
155_N 271_A 1.256 0.99
93_R 124_Q 1.252 0.99
205_L 210_I 1.248 0.99
9_L 13_V 1.248 0.99
112_F 285_C 1.244 0.98
27_C 31_T 1.243 0.98
42_E 79_R 1.24 0.98
51_I 56_C 1.239 0.98
218_L 224_I 1.229 0.98
226_R 229_A 1.223 0.98
239_R 243_A 1.218 0.98
63_K 66_P 1.21 0.98
66_P 70_E 1.203 0.98
13_V 48_F 1.201 0.98
5_R 42_E 1.199 0.98
101_L 125_S 1.196 0.98
136_L 153_A 1.195 0.98
70_E 77_T 1.192 0.98
33_T 37_Q 1.191 0.98
57_L 61_G 1.175 0.98
7_I 76_D 1.173 0.98
170_P 250_E 1.173 0.98
9_L 48_F 1.172 0.98
115_R 285_C 1.166 0.97
12_V 21_A 1.165 0.97
74_V 77_T 1.155 0.97
18_F 55_M 1.148 0.97
9_L 47_L 1.143 0.97
162_Q 240_F 1.141 0.97
166_L 234_V 1.133 0.97
280_H 284_Q 1.13 0.97
155_N 269_H 1.129 0.97
239_R 253_E 1.128 0.97
226_R 230_A 1.127 0.97
225_K 229_A 1.127 0.97
11_T 21_A 1.126 0.97
284_Q 287_E 1.123 0.97
244_K 248_C 1.114 0.96
35_H 38_Q 1.106 0.96
110_Q 230_A 1.106 0.96
113_R 215_T 1.101 0.96
169_S 231_N 1.1 0.96
116_A 281_T 1.097 0.96
112_F 116_A 1.096 0.96
27_C 32_V 1.095 0.96
115_R 288_E 1.091 0.96
34_F 38_Q 1.088 0.96
64_L 68_I 1.084 0.96
167_V 242_V 1.081 0.95
67_H 78_L 1.071 0.95
63_K 67_H 1.067 0.95
170_P 252_I 1.063 0.95
71_L 74_V 1.06 0.95
156_R 266_M 1.059 0.95
122_S 217_E 1.049 0.94
134_A 137_N 1.04 0.94
48_F 55_M 1.039 0.94
76_D 80_E 1.03 0.94
94_V 142_V 1.023 0.93
157_R 269_H 1.022 0.93
168_A 173_A 1.021 0.93
64_L 79_R 1.018 0.93
183_H 186_C 1.016 0.93
6_F 68_I 1.009 0.93
178_T 182_R 1.004 0.93
73_R 77_T 1.003 0.93
189_I 224_I 1.001 0.92
13_V 61_G 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fxqA211000.06Contact Map0.778
1uthA111000.066Contact Map0.732
2esnA411000.069Contact Map0.755
1ixcA20.98631000.075Contact Map0.776
1al3A10.99661000.078Contact Map0.745
3fzvA40.99661000.079Contact Map0.716
2h98A20.98631000.08Contact Map0.78
2h9bA20.98631000.088Contact Map0.764
3szpA20.98291000.098Contact Map0.771
3hhgA80.98631000.107Contact Map0.922
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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