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YGFI - Uncharacterized HTH-type transcriptional regulator YgfI
UniProt: P52044 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12974
Length: 298 (280)
Sequences: 36478
Seq/Len: 130.28
YGFI
Paralog alert: 0.87 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
73_P 77_R 3.828 1.00
18_T 27_K 3.517 1.00
235_V 242_T 2.604 1.00
98_G 142_L 2.506 1.00
23_R 26_E 2.448 1.00
70_K 84_E 2.419 1.00
179_Y 191_L 2.39 1.00
17_Q 72_F 2.329 1.00
170_R 246_H 2.323 1.00
184_E 187_L 2.271 1.00
96_V 124_Q 2.245 1.00
14_L 27_K 2.236 1.00
94_E 122_T 2.234 1.00
74_V 78_L 2.173 1.00
16_A 60_L 2.153 1.00
94_E 124_Q 2.146 1.00
165_E 168_P 2.14 1.00
21_I 39_I 2.117 1.00
70_K 77_R 2.096 1.00
11_N 38_S 2.073 1.00
13_I 68_Y 2.073 1.00
114_L 121_V 2.044 1.00
168_P 270_Q 2.017 1.00
48_Y 63_A 1.999 1.00
68_Y 72_F 1.999 1.00
14_L 18_T 1.958 1.00
14_L 17_Q 1.923 1.00
67_L 81_I 1.922 1.00
13_I 17_Q 1.914 1.00
13_I 72_F 1.907 1.00
194_L 240_F 1.9 1.00
11_N 35_F 1.881 1.00
52_T 59_S 1.858 1.00
165_E 270_Q 1.84 1.00
172_G 246_H 1.818 1.00
192_P 222_I 1.789 1.00
12_F 68_Y 1.771 1.00
16_A 68_Y 1.764 1.00
62_K 65_Q 1.748 1.00
17_Q 27_K 1.731 1.00
133_V 145_I 1.726 1.00
22_A 32_A 1.713 1.00
13_I 71_L 1.712 1.00
66_E 84_E 1.695 1.00
31_T 34_P 1.687 1.00
236_E 256_T 1.649 1.00
11_N 30_M 1.644 1.00
18_T 23_R 1.634 1.00
20_N 23_R 1.623 1.00
90_R 120_G 1.622 1.00
13_I 75_Y 1.614 1.00
175_V 260_F 1.607 1.00
135_D 139_D 1.603 1.00
168_P 268_Y 1.556 1.00
136_N 141_Q 1.536 1.00
70_K 80_A 1.535 1.00
74_V 81_I 1.519 1.00
49_T 52_T 1.504 1.00
8_K 38_S 1.494 1.00
194_L 231_K 1.493 1.00
14_L 28_I 1.479 1.00
8_K 41_A 1.479 1.00
163_I 272_Y 1.474 1.00
65_Q 69_Q 1.454 1.00
205_E 209_D 1.453 1.00
8_K 45_Q 1.438 1.00
67_L 82_D 1.429 1.00
191_L 241_L 1.411 1.00
175_V 179_Y 1.407 0.99
113_S 117_K 1.394 0.99
92_S 120_G 1.386 0.99
40_A 44_E 1.385 0.99
113_S 116_D 1.373 0.99
162_T 275_S 1.371 0.99
6_S 78_L 1.361 0.99
70_K 73_P 1.353 0.99
175_V 241_L 1.34 0.99
231_K 242_T 1.339 0.99
137_L 145_I 1.333 0.99
232_I 252_V 1.327 0.99
162_T 277_R 1.324 0.99
45_Q 82_D 1.304 0.99
112_I 116_D 1.297 0.99
128_F 132_G 1.291 0.99
15_L 39_I 1.288 0.99
115_G 222_I 1.286 0.99
5_I 8_K 1.281 0.99
164_S 275_S 1.271 0.99
136_N 142_L 1.269 0.99
225_P 231_K 1.267 0.99
37_K 40_A 1.252 0.99
12_F 51_F 1.251 0.99
12_F 16_A 1.25 0.99
144_F 273_L 1.247 0.99
180_E 191_L 1.246 0.98
138_F 160_N 1.245 0.98
12_F 50_L 1.245 0.98
115_G 192_P 1.239 0.98
70_K 81_I 1.237 0.98
69_Q 73_P 1.237 0.98
177_R 256_T 1.233 0.98
96_V 126_V 1.231 0.98
36_G 40_A 1.227 0.98
15_L 24_A 1.223 0.98
16_A 51_F 1.221 0.98
30_M 34_P 1.213 0.98
60_L 64_G 1.213 0.98
66_E 69_Q 1.21 0.98
233_S 236_E 1.206 0.98
114_L 118_Y 1.206 0.98
77_R 80_A 1.204 0.98
104_P 127_E 1.195 0.98
54_K 59_S 1.187 0.98
10_R 79_S 1.18 0.98
21_I 58_I 1.174 0.98
14_L 24_A 1.163 0.97
253_N 256_T 1.163 0.97
212_M 217_I 1.162 0.97
246_H 250_R 1.16 0.97
176_S 238_G 1.15 0.97
7_K 10_R 1.123 0.97
147_S 274_Y 1.122 0.97
38_S 41_A 1.119 0.96
173_F 241_L 1.119 0.96
179_Y 192_P 1.116 0.96
233_S 237_R 1.113 0.96
9_M 71_L 1.102 0.96
37_K 41_A 1.101 0.96
112_I 237_R 1.096 0.96
98_G 147_S 1.094 0.96
250_R 253_N 1.089 0.96
149_Q 272_Y 1.088 0.96
174_L 249_W 1.087 0.96
232_I 236_E 1.083 0.96
183_Q 187_L 1.082 0.96
66_E 70_K 1.082 0.96
73_P 80_A 1.081 0.95
276_I 279_H 1.079 0.95
16_A 64_G 1.077 0.95
74_V 77_R 1.075 0.95
169_L 247_F 1.073 0.95
51_F 58_I 1.073 0.95
165_E 272_Y 1.072 0.95
163_I 274_Y 1.067 0.95
30_M 35_F 1.067 0.95
79_S 83_N 1.064 0.95
97_I 144_F 1.062 0.95
192_P 220_T 1.06 0.95
151_V 158_L 1.059 0.95
128_F 136_N 1.055 0.95
124_Q 224_R 1.054 0.95
236_E 252_V 1.046 0.94
67_L 71_L 1.044 0.94
11_N 28_I 1.03 0.94
136_N 139_D 1.014 0.93
15_L 21_I 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.97651000.123Contact Map0.758
3fxqA20.97651000.126Contact Map0.77
1uthA10.97651000.127Contact Map0.75
3fzvA40.97321000.131Contact Map0.706
1al3A10.96981000.137Contact Map0.768
1ixcA20.96641000.139Contact Map0.753
2h98A20.96311000.145Contact Map0.78
2h9bA20.96311000.153Contact Map0.739
3szpA20.9531000.172Contact Map0.741
3hhgA80.95971000.172Contact Map0.928
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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