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OPENSEQ.org
HDFR - HTH-type transcriptional regulator HdfR
UniProt: P0A8R9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11449
Length: 279 (260)
Sequences: 36099
Seq/Len: 138.84
HDFR
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_T 74_T 3.842 1.00
15_T 24_S 3.509 1.00
219_I 226_T 2.54 1.00
94_G 142_L 2.471 1.00
67_Y 81_E 2.443 1.00
20_R 23_E 2.442 1.00
165_T 230_V 2.336 1.00
11_E 24_S 2.288 1.00
14_R 69_E 2.284 1.00
90_E 122_Q 2.261 1.00
92_S 124_E 2.237 1.00
90_E 124_E 2.201 1.00
160_L 163_Y 2.195 1.00
71_L 75_W 2.163 1.00
13_S 57_L 2.115 1.00
163_Y 251_P 2.103 1.00
67_Y 74_T 2.102 1.00
8_T 35_R 2.04 1.00
10_L 65_L 2.039 1.00
45_V 60_A 2.039 1.00
65_L 69_E 2.012 1.00
11_E 15_T 1.988 1.00
111_L 121_L 1.988 1.00
10_L 14_R 1.977 1.00
18_F 36_I 1.977 1.00
10_L 69_E 1.945 1.00
160_L 251_P 1.913 1.00
11_E 14_R 1.912 1.00
8_T 32_V 1.871 1.00
49_T 56_R 1.867 1.00
167_A 230_V 1.852 1.00
64_L 78_A 1.844 1.00
135_K 139_E 1.836 1.00
183_L 224_G 1.832 1.00
13_S 65_L 1.785 1.00
63_K 81_E 1.78 1.00
181_N 206_I 1.745 1.00
59_A 62_E 1.702 1.00
10_L 68_A 1.702 1.00
9_F 65_L 1.698 1.00
14_R 24_S 1.689 1.00
133_L 145_L 1.685 1.00
220_A 238_G 1.68 1.00
17_H 20_R 1.662 1.00
28_T 31_A 1.654 1.00
15_T 20_R 1.646 1.00
163_Y 249_S 1.642 1.00
19_G 29_Q 1.622 1.00
8_T 27_L 1.608 1.00
86_S 120_G 1.597 1.00
10_L 72_M 1.566 1.00
158_S 253_Y 1.565 1.00
170_T 242_V 1.562 1.00
136_Q 141_Q 1.555 1.00
167_A 241_T 1.525 1.00
67_Y 77_A 1.522 1.00
192_Q 196_A 1.511 1.00
11_E 25_L 1.499 1.00
71_L 78_A 1.493 1.00
5_L 38_Q 1.479 1.00
5_L 35_R 1.473 1.00
101_E 213_E 1.47 1.00
46_N 49_T 1.465 1.00
5_L 42_Q 1.452 1.00
3_T 75_W 1.447 1.00
62_E 66_P 1.441 1.00
128_A 132_S 1.428 1.00
88_H 120_G 1.405 0.99
157_S 256_W 1.403 0.99
110_R 117_A 1.396 0.99
183_L 215_A 1.394 0.99
64_L 79_R 1.39 0.99
37_R 41_N 1.381 0.99
67_Y 70_T 1.377 0.99
157_S 258_Q 1.373 0.99
136_Q 142_L 1.361 0.99
2_D 5_L 1.351 0.99
110_R 116_D 1.35 0.99
180_L 225_C 1.338 0.99
159_Q 256_W 1.335 0.99
144_L 254_A 1.33 0.99
109_G 116_D 1.324 0.99
170_T 225_C 1.311 0.99
215_A 226_T 1.304 0.99
209_T 215_A 1.291 0.99
92_S 126_R 1.281 0.99
34_F 37_R 1.278 0.99
42_Q 79_R 1.277 0.99
172_A 238_G 1.277 0.99
9_F 13_S 1.271 0.99
66_P 70_T 1.266 0.99
217_Q 220_A 1.256 0.99
67_Y 78_A 1.25 0.99
12_V 36_I 1.25 0.99
111_L 118_H 1.249 0.99
27_L 31_A 1.249 0.99
51_H 56_R 1.227 0.98
115_Q 181_N 1.218 0.98
100_W 127_I 1.217 0.98
33_S 37_R 1.214 0.98
138_H 155_E 1.212 0.98
12_V 21_A 1.209 0.98
74_T 77_A 1.206 0.98
230_V 234_R 1.2 0.98
9_F 48_F 1.2 0.98
63_K 66_P 1.2 0.98
9_F 47_L 1.185 0.98
137_L 145_L 1.181 0.98
18_F 55_I 1.174 0.98
147_T 255_I 1.158 0.97
13_S 48_F 1.154 0.97
115_Q 206_I 1.152 0.97
164_F 231_S 1.152 0.97
7_K 76_Q 1.15 0.97
57_L 61_G 1.147 0.97
11_E 21_A 1.135 0.97
35_R 38_Q 1.131 0.97
109_G 221_M 1.128 0.97
169_Y 233_A 1.123 0.97
4_E 7_K 1.123 0.97
230_V 241_T 1.117 0.96
171_S 222_L 1.113 0.96
63_K 67_Y 1.108 0.96
94_G 147_T 1.104 0.96
168_L 225_C 1.104 0.96
34_F 38_Q 1.103 0.96
149_E 253_Y 1.102 0.96
158_S 255_I 1.102 0.96
6_L 68_A 1.1 0.96
160_L 253_Y 1.099 0.96
217_Q 221_M 1.095 0.96
70_T 77_A 1.086 0.96
257_L 260_S 1.079 0.95
71_L 74_T 1.075 0.95
124_E 208_T 1.063 0.95
76_Q 80_K 1.063 0.95
27_L 32_V 1.06 0.95
93_I 144_L 1.056 0.95
48_F 55_I 1.052 0.95
196_A 199_I 1.04 0.94
64_L 68_A 1.027 0.94
13_S 61_G 1.027 0.94
79_R 83_A 1.021 0.93
216_Q 220_A 1.017 0.93
106_Q 221_M 1.015 0.93
12_V 18_F 1.006 0.93
8_T 25_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2h98A20.98211000.132Contact Map0.778
3fxqA20.97851000.134Contact Map0.761
2esnA40.98211000.137Contact Map0.762
1uthA10.97851000.138Contact Map0.738
1ixcA20.97491000.138Contact Map0.767
2h9bA20.98211000.14Contact Map0.754
1al3A10.98211000.141Contact Map0.776
3fzvA40.98211000.15Contact Map0.699
3hhgA80.97131000.162Contact Map0.936
3szpA20.96061000.165Contact Map0.743
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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