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OPENSEQ.org
LRHA - Probable HTH-type transcriptional regulator LrhA
UniProt: P36771 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12123
Length: 312 (280)
Sequences: 35990
Seq/Len: 128.54
LRHA
Paralog alert: 0.88 [within 20: 0.48] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
80_K 84_F 3.804 1.00
25_L 34_A 3.483 1.00
164_L 285_E 2.692 1.00
229_V 236_T 2.632 1.00
30_A 33_A 2.465 1.00
104_G 149_V 2.459 1.00
77_Y 91_S 2.379 1.00
24_D 79_R 2.309 1.00
170_P 240_V 2.247 1.00
102_T 131_D 2.241 1.00
100_V 129_A 2.22 1.00
100_V 131_D 2.195 1.00
21_A 34_A 2.192 1.00
120_R 287_Y 2.18 1.00
81_I 85_N 2.153 1.00
165_N 168_T 2.142 1.00
77_Y 84_F 2.131 1.00
23_A 67_L 2.103 1.00
28_F 46_M 2.082 1.00
20_V 75_L 2.082 1.00
18_T 45_Q 2.01 1.00
55_K 70_H 1.997 1.00
75_L 79_R 1.978 1.00
230_K 246_D 1.964 1.00
21_A 25_L 1.964 1.00
20_V 24_D 1.938 1.00
120_R 283_A 1.936 1.00
21_A 24_D 1.92 1.00
20_V 79_R 1.91 1.00
59_A 66_L 1.862 1.00
121_V 128_L 1.846 1.00
18_T 42_V 1.843 1.00
74_L 88_A 1.84 1.00
172_H 240_V 1.81 1.00
226_R 246_D 1.784 1.00
23_A 75_L 1.762 1.00
69_E 72_I 1.748 1.00
142_E 146_S 1.74 1.00
73_Q 91_S 1.731 1.00
20_V 78_A 1.715 1.00
19_F 75_L 1.711 1.00
38_T 41_A 1.707 1.00
29_A 39_Q 1.697 1.00
121_V 280_I 1.697 1.00
140_M 152_M 1.691 1.00
24_D 34_A 1.691 1.00
25_L 30_A 1.673 1.00
18_T 37_R 1.646 1.00
96_N 127_K 1.642 1.00
20_V 82_L 1.623 1.00
27_T 30_A 1.615 1.00
77_Y 87_E 1.511 1.00
151_L 277_A 1.509 1.00
199_R 203_L 1.501 1.00
143_M 148_E 1.498 1.00
111_D 223_P 1.488 1.00
81_I 88_A 1.482 1.00
15_L 45_Q 1.481 1.00
120_R 124_V 1.474 1.00
190_V 234_G 1.471 1.00
72_I 76_G 1.469 1.00
21_A 35_V 1.465 1.00
74_L 89_C 1.464 1.00
15_L 48_R 1.464 1.00
168_T 263_E 1.449 1.00
56_E 59_A 1.446 1.00
175_C 250_L 1.437 1.00
13_L 85_N 1.43 1.00
135_K 139_Y 1.415 1.00
120_R 123_S 1.408 1.00
15_L 52_L 1.401 0.99
98_Q 127_K 1.399 0.99
175_C 235_V 1.399 0.99
12_D 15_L 1.373 0.99
47_Q 51_Q 1.371 0.99
225_V 236_T 1.359 0.99
281_Y 285_E 1.351 0.99
77_Y 80_K 1.334 0.99
273_N 277_A 1.327 0.99
279_V 282_Q 1.322 0.99
119_N 123_S 1.312 0.99
143_M 149_V 1.306 0.99
101_L 280_I 1.303 0.99
52_L 89_C 1.29 0.99
219_A 225_V 1.277 0.99
44_Q 47_Q 1.272 0.99
19_F 23_A 1.266 0.99
121_V 283_A 1.265 0.99
22_V 46_M 1.259 0.99
206_L 211_I 1.249 0.99
102_T 133_R 1.247 0.99
76_G 80_K 1.242 0.98
124_V 283_A 1.242 0.98
77_Y 88_A 1.236 0.98
175_C 179_Y 1.225 0.98
37_R 41_A 1.223 0.98
250_L 253_V 1.215 0.98
122_S 216_A 1.214 0.98
61_H 66_L 1.209 0.98
17_R 86_D 1.206 0.98
19_F 58_F 1.206 0.98
110_A 134_V 1.204 0.98
227_A 230_K 1.203 0.98
19_F 57_L 1.198 0.98
23_A 58_F 1.197 0.98
179_Y 187_I 1.195 0.98
73_Q 76_G 1.189 0.98
43_S 47_Q 1.189 0.98
28_F 65_K 1.185 0.98
84_F 87_E 1.175 0.98
67_L 71_G 1.175 0.98
144_L 152_M 1.174 0.98
22_V 31_A 1.169 0.97
124_V 286_S 1.157 0.97
195_P 216_A 1.153 0.97
282_Q 285_E 1.143 0.97
226_R 230_K 1.141 0.97
176_A 232_G 1.138 0.97
21_A 31_A 1.138 0.97
45_Q 48_R 1.135 0.97
240_V 244_S 1.133 0.97
278_Q 282_Q 1.133 0.97
145_E 160_A 1.132 0.97
104_G 154_T 1.12 0.96
174_Y 243_M 1.12 0.96
14_D 17_R 1.11 0.96
44_Q 48_R 1.108 0.96
175_C 180_I 1.106 0.96
173_W 235_V 1.102 0.96
121_V 125_Y 1.1 0.96
119_N 231_A 1.096 0.96
58_F 65_K 1.096 0.96
73_Q 77_Y 1.088 0.96
169_S 241_E 1.083 0.96
125_Y 279_V 1.082 0.96
131_D 218_V 1.08 0.95
37_R 42_V 1.075 0.95
165_N 263_E 1.074 0.95
227_A 231_A 1.073 0.95
16_L 78_A 1.07 0.95
190_V 197_P 1.063 0.95
86_D 90_S 1.063 0.95
81_I 84_F 1.06 0.95
80_K 87_E 1.056 0.95
23_A 71_G 1.04 0.94
74_L 78_A 1.038 0.94
103_I 151_L 1.022 0.93
18_T 35_V 1.019 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.92311000.288Contact Map0.748
3fzvA40.91351000.295Contact Map0.702
1ixcA20.88781000.296Contact Map0.765
1uthA10.94231000.297Contact Map0.718
2h98A20.93911000.297Contact Map0.738
2h9bA20.93271000.3Contact Map0.731
3fxqA20.91031000.306Contact Map0.756
1al3A10.94871000.311Contact Map0.7
3szpA20.8751000.33Contact Map0.754
3hhgA80.92311000.336Contact Map0.928
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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