May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
NHAR - Transcriptional activator protein NhaR
UniProt: P0A9G2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11078
Length: 301 (285)
Sequences: 36742
Seq/Len: 128.92
NHAR
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
75_K 79_L 3.727 1.00
20_E 29_A 3.416 1.00
234_G 241_F 2.551 1.00
100_G 145_L 2.466 1.00
25_G 28_E 2.402 1.00
72_Y 86_I 2.371 1.00
180_P 192_R 2.326 1.00
171_G 245_T 2.306 1.00
19_K 74_D 2.287 1.00
185_F 188_C 2.202 1.00
16_H 29_A 2.182 1.00
76_M 80_S 2.138 1.00
98_D 127_R 2.131 1.00
166_R 169_E 2.102 1.00
18_Y 62_P 2.099 1.00
169_E 269_E 2.047 1.00
72_Y 79_L 2.04 1.00
23_V 41_I 2.035 1.00
15_W 70_Y 2.007 1.00
13_Y 40_Q 1.99 1.00
70_Y 74_D 1.973 1.00
50_G 65_L 1.952 1.00
16_H 20_E 1.926 1.00
16_H 19_K 1.877 1.00
176_C 260_I 1.873 1.00
15_W 74_D 1.872 1.00
166_R 269_E 1.871 1.00
15_W 19_K 1.87 1.00
69_V 83_M 1.859 1.00
195_L 239_A 1.859 1.00
231_K 251_F 1.854 1.00
54_K 61_E 1.835 1.00
13_Y 37_I 1.827 1.00
118_V 124_I 1.825 1.00
235_A 256_T 1.787 1.00
117_A 290_T 1.784 1.00
173_S 245_T 1.755 1.00
118_V 287_I 1.752 1.00
18_Y 70_Y 1.729 1.00
14_F 70_Y 1.727 1.00
136_L 148_I 1.724 1.00
64_E 67_E 1.719 1.00
235_A 251_F 1.688 1.00
24_V 34_P 1.687 1.00
68_L 86_I 1.687 1.00
19_K 29_A 1.686 1.00
193_R 221_L 1.676 1.00
15_W 73_A 1.661 1.00
33_T 36_T 1.626 1.00
13_Y 32_L 1.619 1.00
138_E 142_Q 1.619 1.00
20_E 25_G 1.602 1.00
15_W 77_F 1.594 1.00
22_S 25_G 1.592 1.00
173_S 259_E 1.561 1.00
139_Q 144_K 1.518 1.00
72_Y 82_E 1.505 1.00
164_S 271_H 1.497 1.00
169_E 267_M 1.477 1.00
195_L 230_M 1.477 1.00
93_S 123_P 1.475 1.00
16_H 30_L 1.467 1.00
10_H 43_A 1.463 1.00
76_M 83_M 1.459 1.00
10_H 40_Q 1.458 1.00
51_K 54_K 1.452 1.00
107_K 228_A 1.451 1.00
8_Y 80_S 1.422 1.00
147_M 284_V 1.42 1.00
67_E 71_R 1.414 1.00
176_C 180_P 1.414 1.00
7_N 10_H 1.411 1.00
183_K 188_C 1.411 1.00
69_V 84_L 1.396 0.99
10_H 47_R 1.393 0.99
192_R 240_I 1.388 0.99
176_C 240_I 1.376 0.99
42_R 46_E 1.373 0.99
204_G 208_L 1.363 0.99
249_Y 253_A 1.356 0.99
163_F 276_E 1.355 0.99
280_Q 284_V 1.351 0.99
117_A 120_E 1.347 0.99
163_F 274_F 1.344 0.99
131_S 135_M 1.33 0.99
117_A 121_G 1.324 0.99
230_M 241_F 1.313 0.99
72_Y 75_K 1.31 0.99
286_R 289_N 1.293 0.99
140_L 148_I 1.287 0.99
178_N 256_T 1.286 0.99
272_A 288_C 1.277 0.99
118_V 290_T 1.262 0.99
224_F 230_M 1.258 0.99
17_V 41_I 1.255 0.99
97_F 287_I 1.248 0.99
165_V 274_F 1.247 0.99
14_F 18_Y 1.243 0.98
251_F 256_T 1.24 0.98
39_G 42_R 1.239 0.98
47_R 84_L 1.222 0.98
71_R 75_K 1.213 0.98
116_A 120_E 1.213 0.98
119_V 193_R 1.212 0.98
139_Q 145_L 1.211 0.98
14_F 53_F 1.207 0.98
141_S 161_G 1.207 0.98
147_M 272_A 1.206 0.98
14_F 52_L 1.206 0.98
98_D 129_F 1.205 0.98
17_V 26_A 1.204 0.98
38_T 42_R 1.201 0.98
62_P 66_G 1.193 0.98
245_T 249_Y 1.19 0.98
68_L 71_R 1.188 0.98
72_Y 83_M 1.188 0.98
32_L 36_T 1.184 0.98
119_V 221_L 1.182 0.98
232_A 235_A 1.181 0.98
18_Y 53_F 1.18 0.98
12_Y 81_Q 1.179 0.98
79_L 82_E 1.174 0.98
211_F 216_L 1.167 0.97
56_K 61_E 1.164 0.97
23_V 60_L 1.162 0.97
150_S 273_I 1.156 0.97
121_G 290_T 1.139 0.97
245_T 259_E 1.126 0.97
16_H 26_A 1.123 0.97
106_S 130_E 1.123 0.97
152_C 271_H 1.122 0.97
248_A 251_F 1.116 0.96
177_T 237_H 1.107 0.96
178_N 258_V 1.103 0.96
285_Q 289_N 1.1 0.96
95_L 123_P 1.096 0.96
9_N 12_Y 1.096 0.96
100_G 150_S 1.094 0.96
11_L 73_A 1.088 0.96
40_Q 43_A 1.085 0.96
231_K 235_A 1.082 0.96
68_L 72_Y 1.072 0.95
174_F 240_I 1.069 0.95
170_C 246_L 1.066 0.95
166_R 271_H 1.062 0.95
39_G 43_A 1.062 0.95
232_A 236_M 1.062 0.95
180_P 193_R 1.059 0.95
75_K 82_E 1.054 0.95
32_L 37_I 1.053 0.95
274_F 288_C 1.052 0.95
116_A 236_M 1.05 0.94
164_S 273_I 1.05 0.94
193_R 219_E 1.05 0.94
18_Y 66_G 1.046 0.94
76_M 79_L 1.04 0.94
53_F 60_L 1.039 0.94
69_V 73_A 1.033 0.94
81_Q 85_D 1.032 0.94
248_A 252_Y 1.022 0.93
13_Y 30_L 1.01 0.93
17_V 23_V 1.002 0.92
17_V 53_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.99341000.128Contact Map0.754
1uthA10.98341000.133Contact Map0.726
3fxqA20.97671000.136Contact Map0.784
3fzvA40.97341000.143Contact Map0.718
1ixcA20.94681000.152Contact Map0.76
2h98A20.95681000.153Contact Map0.771
1al3A10.96681000.154Contact Map0.807
2h9bA20.95681000.16Contact Map0.773
3szpA20.94351000.172Contact Map0.763
3hhgA80.96351000.183Contact Map0.924
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0363 seconds.