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OPENSEQ.org
DMLR - HTH-type transcriptional regulator DmlR
UniProt: P76250 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13506
Length: 307 (292)
Sequences: 37010
Seq/Len: 126.75
DMLR
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_R 78_D 3.721 1.00
19_R 28_E 3.396 1.00
159_R 292_R 2.607 1.00
100_I 142_V 2.49 1.00
234_C 241_A 2.467 1.00
24_A 27_E 2.371 1.00
71_W 85_E 2.33 1.00
165_Y 245_W 2.279 1.00
18_R 73_Q 2.23 1.00
183_H 186_D 2.204 1.00
174_F 190_L 2.186 1.00
15_L 28_E 2.184 1.00
98_R 127_R 2.165 1.00
96_M 125_E 2.139 1.00
96_M 127_R 2.115 1.00
75_I 79_V 2.113 1.00
160_K 163_T 2.102 1.00
163_T 269_N 2.081 1.00
17_A 61_I 2.068 1.00
71_W 78_D 2.06 1.00
116_A 294_Y 2.041 1.00
231_H 251_N 2.037 1.00
22_F 40_I 2.01 1.00
12_V 39_R 1.999 1.00
14_M 69_Y 1.972 1.00
69_Y 73_Q 1.945 1.00
49_V 64_E 1.938 1.00
160_K 269_N 1.918 1.00
14_M 18_R 1.897 1.00
15_L 19_R 1.895 1.00
14_M 73_Q 1.883 1.00
15_L 18_R 1.88 1.00
116_A 290_F 1.85 1.00
12_V 36_V 1.837 1.00
193_L 239_G 1.837 1.00
68_I 82_M 1.811 1.00
53_H 60_T 1.81 1.00
117_L 124_L 1.806 1.00
167_I 245_W 1.795 1.00
235_L 251_N 1.761 1.00
17_A 69_Y 1.747 1.00
191_P 221_P 1.686 1.00
63_E 66_E 1.677 1.00
13_F 69_Y 1.676 1.00
67_R 85_E 1.672 1.00
14_M 72_A 1.668 1.00
18_R 28_E 1.667 1.00
23_A 33_P 1.644 1.00
117_L 287_T 1.623 1.00
235_L 256_H 1.62 1.00
12_V 31_V 1.606 1.00
32_S 35_F 1.605 1.00
21_G 24_A 1.601 1.00
163_T 267_P 1.595 1.00
19_R 24_A 1.579 1.00
14_M 76_L 1.56 1.00
92_V 123_Q 1.535 1.00
158_A 271_W 1.531 1.00
71_W 81_Q 1.495 1.00
75_I 82_M 1.469 1.00
9_D 42_L 1.459 1.00
15_L 29_L 1.448 1.00
107_R 228_E 1.446 1.00
144_L 284_V 1.436 1.00
193_L 230_V 1.427 1.00
50_V 53_H 1.425 1.00
9_D 39_R 1.422 1.00
116_A 120_A 1.419 1.00
167_I 259_Q 1.408 1.00
7_L 79_V 1.403 0.99
9_D 46_T 1.401 0.99
157_I 276_S 1.372 0.99
66_E 70_E 1.369 0.99
190_L 240_I 1.366 0.99
68_I 83_M 1.352 0.99
41_A 45_Q 1.351 0.99
94_Q 123_Q 1.348 0.99
157_I 274_Y 1.348 0.99
170_A 260_V 1.338 0.99
71_W 74_R 1.324 0.99
170_A 240_I 1.319 0.99
280_T 284_V 1.314 0.99
136_D 139_N 1.313 0.99
6_L 9_D 1.312 0.99
288_V 292_R 1.312 0.99
116_A 119_K 1.311 0.99
286_I 289_E 1.298 0.99
249_S 253_A 1.297 0.99
272_A 288_V 1.296 0.99
180_A 258_V 1.293 0.99
230_V 241_A 1.279 0.99
115_L 119_K 1.277 0.99
159_R 274_Y 1.274 0.99
179_G 186_D 1.27 0.99
117_L 290_F 1.26 0.99
13_F 17_A 1.252 0.99
38_K 41_A 1.251 0.99
118_A 191_P 1.246 0.98
224_S 230_V 1.238 0.98
251_N 256_H 1.232 0.98
46_T 83_M 1.228 0.98
134_L 145_D 1.225 0.98
120_A 290_F 1.217 0.98
13_F 52_L 1.215 0.98
70_E 74_R 1.208 0.98
245_W 249_S 1.207 0.98
232_Q 235_L 1.199 0.98
170_A 174_F 1.198 0.98
97_L 287_T 1.198 0.98
67_R 70_E 1.198 0.98
71_W 82_M 1.197 0.98
31_V 35_F 1.194 0.98
16_V 40_I 1.186 0.98
98_R 129_D 1.185 0.98
118_A 221_P 1.183 0.98
37_S 41_A 1.182 0.98
13_F 51_L 1.18 0.98
55_T 60_T 1.18 0.98
144_L 272_A 1.178 0.98
61_I 65_G 1.174 0.98
147_R 273_V 1.174 0.98
78_D 81_Q 1.172 0.98
106_G 130_V 1.171 0.98
16_V 25_V 1.171 0.98
22_F 59_V 1.163 0.97
274_Y 288_V 1.142 0.97
17_A 52_L 1.14 0.97
11_R 80_G 1.139 0.97
15_L 25_V 1.115 0.96
285_R 289_E 1.107 0.96
289_E 292_R 1.107 0.96
39_R 42_L 1.1 0.96
182_K 186_D 1.098 0.96
100_I 147_R 1.088 0.96
137_L 145_D 1.088 0.96
245_W 259_Q 1.084 0.96
164_N 246_W 1.084 0.96
158_A 273_V 1.08 0.95
171_S 237_G 1.079 0.95
8_N 11_R 1.079 0.95
115_L 236_D 1.076 0.95
10_L 72_A 1.075 0.95
67_R 71_W 1.073 0.95
149_G 271_W 1.073 0.95
168_L 240_I 1.073 0.95
160_K 271_W 1.069 0.95
117_L 121_Y 1.068 0.95
38_K 42_L 1.066 0.95
120_A 293_Q 1.065 0.95
138_V 155_N 1.064 0.95
174_F 191_P 1.058 0.95
259_Q 262_P 1.056 0.95
232_Q 236_D 1.055 0.95
52_L 59_V 1.05 0.94
136_D 141_G 1.049 0.94
231_H 235_L 1.047 0.94
121_Y 286_I 1.045 0.94
75_I 78_D 1.044 0.94
80_G 84_D 1.041 0.94
31_V 36_V 1.039 0.94
127_R 223_S 1.038 0.94
250_E 254_S 1.036 0.94
169_C 248_V 1.036 0.94
74_R 81_Q 1.031 0.94
68_I 72_A 1.028 0.94
191_P 219_T 1.026 0.94
17_A 65_G 1.015 0.93
211_E 216_I 1.013 0.93
99_I 144_L 1.008 0.93
275_V 278_L 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hhgA80.9871000.191Contact Map0.923
2esnA40.96741000.193Contact Map0.766
3szpA20.94141000.197Contact Map0.774
1ixcA20.94461000.204Contact Map0.762
1uthA10.98051000.205Contact Map0.755
3fzvA40.97391000.205Contact Map0.712
3fxqA20.97071000.207Contact Map0.787
2h98A20.97391000.211Contact Map0.722
2h9bA20.97391000.212Contact Map0.723
1al3A10.97721000.215Contact Map0.741
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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