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OPENSEQ.org
METR - HTH-type transcriptional regulator MetR
UniProt: P0A9F9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10591
Length: 317 (289)
Sequences: 36405
Seq/Len: 125.97
METR
Paralog alert: 0.88 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_Q 75_Q 3.745 1.00
16_C 25_T 3.393 1.00
156_S 286_R 2.595 1.00
228_V 235_A 2.472 1.00
94_A 139_L 2.41 1.00
21_A 24_A 2.374 1.00
162_E 239_H 2.276 1.00
171_H 187_E 2.238 1.00
12_A 25_T 2.222 1.00
15_N 70_N 2.212 1.00
180_T 183_D 2.189 1.00
92_R 121_D 2.175 1.00
72_V 76_I 2.145 1.00
90_R 119_E 2.136 1.00
157_P 160_D 2.118 1.00
68_L 75_Q 2.096 1.00
160_D 263_R 2.091 1.00
90_R 121_D 2.085 1.00
14_R 58_F 2.083 1.00
110_N 288_H 2.075 1.00
19_L 37_F 1.999 1.00
225_I 245_F 1.995 1.00
11_Q 66_L 1.993 1.00
66_L 70_N 1.961 1.00
9_T 36_Q 1.96 1.00
46_F 61_Q 1.931 1.00
12_A 16_C 1.928 1.00
157_P 263_R 1.92 1.00
11_Q 15_N 1.87 1.00
11_Q 70_N 1.867 1.00
110_N 284_S 1.854 1.00
65_L 79_A 1.853 1.00
9_T 33_L 1.845 1.00
12_A 15_N 1.829 1.00
190_L 233_G 1.811 1.00
50_V 57_R 1.808 1.00
111_F 118_V 1.808 1.00
229_A 245_F 1.768 1.00
164_R 239_H 1.766 1.00
14_R 66_L 1.738 1.00
15_N 25_T 1.709 1.00
60_P 63_E 1.7 1.00
111_F 281_F 1.675 1.00
130_P 142_V 1.667 1.00
10_L 66_L 1.666 1.00
167_L 254_K 1.664 1.00
11_Q 69_A 1.655 1.00
160_D 261_W 1.642 1.00
229_A 250_L 1.619 1.00
20_A 30_Q 1.618 1.00
29_T 32_A 1.609 1.00
9_T 28_Q 1.594 1.00
18_S 21_A 1.592 1.00
16_C 21_A 1.591 1.00
11_Q 73_L 1.587 1.00
132_P 136_Q 1.571 1.00
86_P 117_Q 1.547 1.00
155_Y 265_Y 1.525 1.00
176_K 183_D 1.504 1.00
133_A 138_E 1.483 1.00
72_V 79_A 1.48 1.00
199_L 203_R 1.467 1.00
190_L 224_L 1.467 1.00
6_H 39_D 1.456 1.00
68_L 78_Q 1.436 1.00
6_H 36_Q 1.436 1.00
12_A 26_L 1.432 1.00
110_N 114_N 1.43 1.00
101_I 222_L 1.423 1.00
47_R 50_V 1.421 1.00
63_E 67_Q 1.409 1.00
6_H 43_R 1.406 0.99
164_R 253_T 1.406 0.99
141_L 278_T 1.387 0.99
4_V 76_I 1.385 0.99
154_H 270_D 1.373 0.99
167_L 234_I 1.357 0.99
187_E 234_I 1.357 0.99
154_H 268_V 1.342 0.99
38_S 42_Q 1.34 0.99
266_A 282_I 1.34 0.99
110_N 113_K 1.337 0.99
274_R 278_T 1.334 0.99
88_Q 117_Q 1.324 0.99
68_L 71_Q 1.32 0.99
3_E 6_H 1.303 0.99
224_L 235_A 1.301 0.99
125_G 129_D 1.298 0.99
280_A 283_R 1.297 0.99
109_E 113_K 1.28 0.99
245_F 250_L 1.278 0.99
282_I 286_R 1.278 0.99
134_L 142_V 1.261 0.99
156_S 268_V 1.26 0.99
243_E 247_R 1.252 0.99
10_L 14_R 1.251 0.99
111_F 284_S 1.247 0.99
68_L 79_A 1.244 0.98
114_N 284_S 1.242 0.98
172_P 187_E 1.236 0.98
100_C 124_S 1.225 0.98
239_H 243_E 1.22 0.98
13_L 37_F 1.219 0.98
67_Q 71_Q 1.213 0.98
133_A 139_L 1.204 0.98
253_T 256_L 1.203 0.98
226_Q 229_A 1.198 0.98
35_H 38_S 1.197 0.98
91_L 281_F 1.196 0.98
28_Q 32_A 1.192 0.98
141_L 266_A 1.186 0.98
206_L 211_V 1.179 0.98
92_R 123_K 1.178 0.98
13_L 22_A 1.176 0.98
179_I 183_D 1.175 0.98
10_L 49_F 1.172 0.98
10_L 48_L 1.169 0.97
135_Q 152_G 1.163 0.97
75_Q 78_Q 1.161 0.97
112_H 188_T 1.16 0.97
52_K 57_R 1.159 0.97
268_V 282_I 1.157 0.97
144_T 267_A 1.156 0.97
14_R 49_F 1.156 0.97
34_S 38_S 1.155 0.97
19_L 56_L 1.15 0.97
64_I 67_Q 1.143 0.97
8_K 77_S 1.134 0.97
58_F 62_G 1.132 0.97
12_A 22_A 1.123 0.97
279_E 283_R 1.119 0.96
5_K 8_K 1.114 0.96
283_R 286_R 1.108 0.96
157_P 265_Y 1.103 0.96
171_H 188_T 1.101 0.96
36_Q 39_D 1.099 0.96
114_N 287_N 1.099 0.96
166_V 242_V 1.097 0.96
165_L 234_I 1.097 0.96
218_V 224_L 1.097 0.96
109_E 230_A 1.096 0.96
168_A 231_R 1.093 0.96
167_L 171_H 1.093 0.96
35_H 39_D 1.093 0.96
7_L 69_A 1.091 0.96
239_H 253_T 1.083 0.96
226_Q 230_A 1.079 0.95
111_F 115_W 1.067 0.95
225_I 229_A 1.057 0.95
146_D 265_Y 1.057 0.95
72_V 75_Q 1.051 0.94
161_Y 240_W 1.05 0.94
65_L 69_A 1.049 0.94
115_W 280_A 1.049 0.94
28_Q 33_L 1.048 0.94
244_S 248_Q 1.048 0.94
177_T 252_V 1.046 0.94
71_Q 78_Q 1.044 0.94
155_Y 267_A 1.035 0.94
93_I 141_L 1.03 0.94
49_F 56_L 1.027 0.94
94_A 144_T 1.027 0.94
14_R 62_G 1.022 0.93
125_G 133_A 1.021 0.93
64_I 68_L 1.017 0.93
269_R 272_E 1.007 0.93
173_L 176_K 1.006 0.93
133_A 136_Q 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.92431000.215Contact Map0.757
3fxqA20.93691000.217Contact Map0.778
3fzvA40.93381000.22Contact Map0.725
1uthA10.93691000.224Contact Map0.725
1ixcA20.90541000.225Contact Map0.759
1al3A10.96851000.233Contact Map0.763
2h98A20.94011000.24Contact Map0.767
2h9bA20.94641000.242Contact Map0.752
3szpA20.90221000.243Contact Map0.78
3hhgA80.94011000.252Contact Map0.922
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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