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OPENSEQ.org
OXYR - Hydrogen peroxide-inducible genes activator
UniProt: P0ACQ4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10681
Length: 305 (294)
Sequences: 37278
Seq/Len: 126.80
OXYR
Paralog alert: 0.87 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
70_T 74_E 3.717 1.00
15_H 24_S 3.368 1.00
158_V 290_R 2.593 1.00
231_V 238_T 2.481 1.00
96_G 141_L 2.379 1.00
20_R 23_D 2.337 1.00
67_Q 81_M 2.315 1.00
164_P 242_A 2.244 1.00
11_A 24_S 2.198 1.00
14_E 69_R 2.188 1.00
182_P 185_D 2.18 1.00
94_H 123_Y 2.174 1.00
173_H 189_E 2.153 1.00
92_P 121_E 2.142 1.00
71_V 75_V 2.108 1.00
92_P 123_Y 2.104 1.00
112_M 292_R 2.094 1.00
159_P 162_D 2.08 1.00
162_D 267_T 2.056 1.00
67_Q 74_E 2.03 1.00
13_A 57_F 2.028 1.00
228_R 248_E 2.002 1.00
10_V 65_V 1.976 1.00
45_V 60_A 1.963 1.00
8_Y 35_Q 1.956 1.00
65_V 69_R 1.928 1.00
18_F 36_I 1.919 1.00
11_A 15_H 1.888 1.00
159_P 267_T 1.871 1.00
10_V 69_R 1.85 1.00
232_A 248_E 1.845 1.00
112_M 288_A 1.836 1.00
10_V 14_E 1.835 1.00
11_A 14_E 1.819 1.00
49_E 56_L 1.804 1.00
64_L 78_L 1.802 1.00
8_Y 32_L 1.785 1.00
192_L 236_G 1.785 1.00
113_L 120_L 1.744 1.00
166_L 242_A 1.737 1.00
190_K 218_H 1.732 1.00
13_A 65_V 1.717 1.00
232_A 253_G 1.711 1.00
134_A 138_S 1.668 1.00
59_Q 62_M 1.662 1.00
9_L 65_V 1.66 1.00
63_L 81_M 1.643 1.00
14_E 24_S 1.635 1.00
10_V 68_A 1.632 1.00
169_I 257_L 1.623 1.00
132_L 144_V 1.617 1.00
19_R 29_Q 1.605 1.00
28_S 31_T 1.581 1.00
15_H 20_R 1.573 1.00
8_Y 27_V 1.57 1.00
17_H 20_R 1.559 1.00
178_R 185_D 1.558 1.00
10_V 72_L 1.556 1.00
88_T 119_K 1.554 1.00
113_L 285_L 1.551 1.00
162_D 265_R 1.546 1.00
157_E 269_G 1.511 1.00
67_Q 77_V 1.487 1.00
135_Q 140_K 1.484 1.00
103_P 225_E 1.448 1.00
11_A 25_C 1.443 1.00
71_V 78_L 1.424 1.00
46_M 49_E 1.419 1.00
112_M 116_T 1.41 1.00
192_L 227_L 1.41 1.00
5_D 38_K 1.404 0.99
3_I 75_V 1.395 0.99
143_C 282_Y 1.388 0.99
5_D 42_E 1.385 0.99
5_D 35_Q 1.375 0.99
201_R 205_M 1.361 0.99
189_E 237_I 1.36 0.99
62_M 66_D 1.358 0.99
64_L 79_K 1.353 0.99
90_S 119_K 1.349 0.99
166_L 256_Y 1.345 0.99
112_M 115_Q 1.344 0.99
37_R 41_D 1.329 0.99
156_I 272_Y 1.324 0.99
284_Q 287_E 1.316 0.99
270_L 286_A 1.311 0.99
156_I 274_P 1.31 0.99
2_N 5_D 1.308 0.99
169_I 237_I 1.308 0.99
67_Q 70_T 1.307 0.99
135_Q 141_L 1.305 0.99
227_L 238_T 1.296 0.99
171_E 253_G 1.294 0.99
111_P 115_Q 1.279 0.99
278_L 282_Y 1.273 0.99
286_A 290_R 1.269 0.99
158_V 272_Y 1.236 0.98
221_A 227_L 1.227 0.98
42_E 79_K 1.221 0.98
9_L 13_A 1.217 0.98
127_A 131_Q 1.216 0.98
248_E 253_G 1.216 0.98
116_T 288_A 1.212 0.98
114_H 190_K 1.208 0.98
174_P 189_E 1.205 0.98
34_G 37_R 1.204 0.98
66_D 70_T 1.203 0.98
229_N 232_A 1.203 0.98
137_D 154_A 1.2 0.98
242_A 246_P 1.192 0.98
67_Q 78_L 1.191 0.98
246_P 250_K 1.189 0.98
94_H 125_H 1.187 0.98
12_L 36_I 1.182 0.98
63_L 66_D 1.178 0.98
9_L 48_L 1.177 0.98
113_L 288_A 1.175 0.98
114_H 218_H 1.175 0.98
27_V 31_T 1.174 0.98
51_T 56_L 1.173 0.98
93_L 285_L 1.167 0.97
146_L 271_V 1.157 0.97
74_E 77_V 1.152 0.97
143_C 270_L 1.151 0.97
57_F 61_G 1.144 0.97
33_S 37_R 1.144 0.97
9_L 47_L 1.143 0.97
7_E 76_K 1.14 0.97
208_C 213_A 1.139 0.97
13_A 48_L 1.139 0.97
12_L 21_A 1.133 0.97
272_Y 286_A 1.129 0.97
287_E 290_R 1.129 0.97
18_F 55_V 1.126 0.97
181_V 185_D 1.123 0.97
283_E 287_E 1.114 0.96
148_L 269_G 1.113 0.96
11_A 21_A 1.102 0.96
170_Y 234_G 1.08 0.95
35_Q 38_K 1.079 0.95
4_R 7_E 1.078 0.95
157_E 271_V 1.072 0.95
111_P 233_A 1.071 0.95
229_N 233_A 1.07 0.95
34_G 38_K 1.069 0.95
228_R 232_A 1.068 0.95
159_P 269_G 1.064 0.95
63_L 67_Q 1.064 0.95
167_L 237_I 1.062 0.95
136_L 144_V 1.061 0.95
163_E 243_L 1.061 0.95
171_E 255_V 1.061 0.95
6_L 68_A 1.061 0.95
116_T 291_A 1.061 0.95
179_E 255_V 1.057 0.95
247_P 251_R 1.055 0.95
169_I 173_H 1.054 0.95
27_V 32_L 1.042 0.94
113_L 117_F 1.038 0.94
76_K 80_E 1.031 0.94
70_T 77_V 1.028 0.94
173_H 190_K 1.026 0.94
71_V 74_E 1.024 0.93
117_F 284_Q 1.022 0.93
96_G 146_L 1.017 0.93
123_Y 220_R 1.016 0.93
48_L 55_V 1.01 0.93
127_A 135_Q 1.006 0.93
273_R 276_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2esnA40.97381000.13Contact Map0.758
1ixcA20.95741000.133Contact Map0.756
1uthA10.98031000.133Contact Map0.723
3fxqA20.98691000.135Contact Map0.781
3fzvA40.98361000.135Contact Map0.71
2h98A20.98691000.137Contact Map0.765
1al3A10.99671000.141Contact Map0.752
2h9bA20.98361000.151Contact Map0.753
3szpA20.95411000.159Contact Map0.764
3hhgA80.98031000.171Contact Map0.926
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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