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OPENSEQ.org
ICIA - Chromosome initiation inhibitor
UniProt: P0A8S1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10490
Length: 297 (286)
Sequences: 37125
Seq/Len: 129.81
ICIA
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
18_E 27_K 3.366 1.00
72_Q 76_L 3.276 1.00
157_D 287_L 2.51 1.00
231_A 238_C 2.496 1.00
96_A 140_V 2.409 1.00
23_R 26_Q 2.374 1.00
163_D 242_H 2.27 1.00
17_R 71_R 2.256 1.00
14_A 27_K 2.189 1.00
182_T 185_A 2.157 1.00
92_L 120_R 2.138 1.00
94_S 122_N 2.137 1.00
172_F 189_A 2.128 1.00
92_L 122_N 2.116 1.00
16_I 59_P 2.097 1.00
158_K 161_A 2.059 1.00
69_L 83_D 2.058 1.00
228_V 248_E 2.031 1.00
21_F 39_I 2.001 1.00
161_A 264_R 1.979 1.00
11_A 38_R 1.97 1.00
13_D 67_L 1.966 1.00
48_Q 62_Q 1.959 1.00
112_P 289_Y 1.953 1.00
66_L 80_W 1.938 1.00
67_L 71_R 1.933 1.00
14_A 18_E 1.896 1.00
13_D 17_R 1.856 1.00
13_D 71_R 1.85 1.00
14_A 17_R 1.841 1.00
113_V 119_I 1.838 1.00
192_V 236_T 1.836 1.00
131_T 143_A 1.831 1.00
11_A 35_V 1.825 1.00
52_V 58_R 1.821 1.00
133_E 137_R 1.813 1.00
73_V 77_E 1.79 1.00
112_P 285_A 1.787 1.00
158_K 264_R 1.775 1.00
165_L 242_H 1.765 1.00
232_R 248_E 1.76 1.00
69_L 76_L 1.759 1.00
16_I 67_L 1.741 1.00
190_P 218_C 1.709 1.00
61_E 64_Q 1.699 1.00
13_D 70_L 1.666 1.00
17_R 27_K 1.664 1.00
12_L 67_L 1.659 1.00
232_R 253_E 1.653 1.00
113_V 282_V 1.635 1.00
178_P 185_A 1.62 1.00
22_E 32_Q 1.602 1.00
11_A 30_I 1.594 1.00
31_T 34_A 1.591 1.00
18_E 23_R 1.577 1.00
20_G 23_R 1.577 1.00
88_S 118_P 1.566 1.00
168_S 257_L 1.503 1.00
134_R 139_E 1.502 1.00
65_K 83_D 1.489 1.00
192_V 227_F 1.489 1.00
14_A 28_L 1.459 1.00
165_L 256_D 1.452 1.00
69_L 79_E 1.445 1.00
8_T 38_R 1.442 1.00
156_V 266_M 1.433 1.00
8_T 41_Q 1.423 1.00
49_P 52_V 1.417 1.00
112_P 116_D 1.412 1.00
8_T 45_M 1.402 0.99
13_D 74_E 1.396 0.99
64_Q 68_A 1.391 0.99
103_A 225_E 1.369 0.99
142_G 279_M 1.357 0.99
5_D 8_T 1.355 0.99
189_A 237_C 1.355 0.99
40_K 44_N 1.333 0.99
275_E 279_M 1.313 0.99
168_S 237_C 1.309 0.99
112_P 115_A 1.304 0.99
90_P 118_P 1.299 0.99
246_E 250_A 1.294 0.99
227_F 238_C 1.288 0.99
135_L 143_A 1.285 0.99
69_L 72_Q 1.278 0.99
6_Y 77_E 1.276 0.99
267_L 283_T 1.272 0.99
111_A 115_A 1.261 0.99
15_V 39_I 1.258 0.99
126_E 130_R 1.258 0.99
281_K 284_D 1.257 0.99
155_L 271_R 1.255 0.99
37_Q 40_K 1.255 0.99
134_R 140_V 1.249 0.99
155_L 269_W 1.248 0.99
283_T 287_L 1.248 0.99
221_V 227_F 1.233 0.98
12_L 16_I 1.231 0.98
93_L 282_V 1.213 0.98
114_L 190_P 1.21 0.98
94_S 124_Q 1.2 0.98
12_L 50_L 1.197 0.98
12_L 51_L 1.194 0.98
229_Q 232_R 1.186 0.98
248_E 253_E 1.185 0.98
65_K 68_A 1.183 0.98
16_I 51_L 1.183 0.98
68_A 72_Q 1.18 0.98
161_A 262_F 1.178 0.98
30_I 34_A 1.17 0.97
36_S 40_K 1.169 0.97
116_D 285_A 1.168 0.97
179_N 255_I 1.166 0.97
136_R 153_S 1.165 0.97
157_D 269_W 1.163 0.97
113_V 285_A 1.161 0.97
173_A 189_A 1.16 0.97
114_L 218_C 1.158 0.97
15_V 24_A 1.157 0.97
59_P 63_G 1.153 0.97
21_F 57_P 1.151 0.97
242_H 246_E 1.145 0.97
45_M 81_L 1.141 0.97
73_V 80_W 1.139 0.97
54_T 58_R 1.13 0.97
162_L 243_L 1.128 0.97
145_S 268_Y 1.126 0.97
14_A 24_A 1.125 0.97
102_L 125_V 1.108 0.96
77_E 80_W 1.097 0.96
269_W 283_T 1.096 0.96
74_E 77_E 1.096 0.96
7_R 10_Q 1.095 0.96
38_R 41_Q 1.092 0.96
169_S 234_G 1.088 0.96
168_S 172_F 1.087 0.96
111_A 233_Q 1.083 0.96
72_Q 75_L 1.08 0.95
280_R 284_D 1.08 0.95
65_K 69_L 1.076 0.95
167_V 245_I 1.073 0.95
113_V 117_S 1.068 0.95
122_N 220_I 1.066 0.95
116_D 288_D 1.063 0.95
166_F 237_C 1.06 0.95
142_G 267_L 1.06 0.95
9_L 70_L 1.059 0.95
228_V 232_R 1.058 0.95
170_K 253_E 1.057 0.95
242_H 256_D 1.055 0.95
172_F 190_P 1.054 0.95
229_Q 233_Q 1.05 0.94
51_L 57_P 1.042 0.94
284_D 287_L 1.041 0.94
66_L 70_L 1.041 0.94
37_Q 41_Q 1.04 0.94
181_V 185_A 1.04 0.94
73_V 76_L 1.035 0.94
256_D 259_P 1.035 0.94
156_V 268_Y 1.035 0.94
30_I 35_V 1.024 0.93
16_I 63_G 1.023 0.93
168_S 173_A 1.021 0.93
247_K 251_S 1.021 0.93
270_H 273_A 1.019 0.93
95_L 142_G 1.011 0.93
72_Q 79_E 1.01 0.93
10_Q 78_E 1.007 0.93
96_A 145_S 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fzvA40.98651000.119Contact Map0.711
2esnA40.97641000.13Contact Map0.749
1uthA10.98321000.133Contact Map0.721
1ixcA20.95621000.135Contact Map0.756
3fxqA20.97641000.144Contact Map0.771
3hhgA80.97981000.145Contact Map0.926
1al3A10.97311000.149Contact Map0.749
2h98A20.97311000.149Contact Map0.727
3ispA20.98321000.153Contact Map0.714
3szpA20.94611000.155Contact Map0.788
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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