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OPENSEQ.org
GCVA - Glycine cleavage system transcriptional activator
UniProt: P0A9F6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11795
Length: 305 (289)
Sequences: 36943
Seq/Len: 127.83
GCVA
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
75_E 79_Q 3.715 1.00
20_H 29_E 3.415 1.00
158_E 289_L 2.588 1.00
99_S 141_V 2.54 1.00
230_A 237_A 2.512 1.00
25_R 28_E 2.392 1.00
164_Y 241_N 2.313 1.00
72_D 86_K 2.302 1.00
19_R 74_K 2.272 1.00
173_L 189_H 2.196 1.00
97_T 126_R 2.18 1.00
16_A 29_E 2.167 1.00
76_I 80_L 2.15 1.00
95_A 124_D 2.145 1.00
18_A 62_L 2.106 1.00
95_A 126_R 2.105 1.00
182_T 185_D 2.102 1.00
115_S 291_K 2.09 1.00
159_K 162_A 2.078 1.00
162_A 266_A 2.07 1.00
72_D 79_Q 2.061 1.00
227_L 247_E 2.033 1.00
23_F 41_I 2.033 1.00
15_D 70_F 2.015 1.00
13_V 40_Q 1.984 1.00
70_F 74_K 1.983 1.00
50_L 65_E 1.953 1.00
16_A 20_H 1.914 1.00
159_K 266_A 1.877 1.00
13_V 37_V 1.876 1.00
16_A 19_R 1.875 1.00
15_D 74_K 1.872 1.00
116_F 123_I 1.852 1.00
15_D 19_R 1.851 1.00
115_S 287_W 1.839 1.00
69_Y 83_A 1.827 1.00
192_L 235_G 1.825 1.00
54_R 61_L 1.809 1.00
231_I 247_E 1.807 1.00
18_A 70_F 1.763 1.00
166_L 241_N 1.763 1.00
14_F 70_F 1.704 1.00
64_E 67_Q 1.699 1.00
19_R 29_E 1.693 1.00
116_F 284_F 1.688 1.00
15_D 73_I 1.675 1.00
24_T 34_Q 1.631 1.00
68_S 86_K 1.631 1.00
22_S 25_R 1.622 1.00
33_T 36_A 1.617 1.00
13_V 32_V 1.608 1.00
15_D 77_F 1.599 1.00
20_H 25_R 1.59 1.00
231_I 252_R 1.587 1.00
190_T 217_G 1.577 1.00
162_A 264_K 1.572 1.00
157_V 268_Y 1.534 1.00
192_L 226_V 1.515 1.00
72_D 82_E 1.488 1.00
76_I 83_A 1.468 1.00
10_A 43_S 1.462 1.00
16_A 30_L 1.441 1.00
10_A 40_Q 1.44 1.00
177_E 185_D 1.431 1.00
106_I 224_A 1.427 1.00
143_V 281_I 1.426 1.00
115_S 119_A 1.412 1.00
51_K 54_R 1.409 1.00
67_Q 71_L 1.4 0.99
10_A 47_F 1.399 0.99
189_H 236_V 1.394 0.99
8_L 80_L 1.388 0.99
69_Y 84_T 1.37 0.99
42_K 46_D 1.365 0.99
200_W 203_Y 1.348 0.99
269_L 285_R 1.346 0.99
93_K 122_G 1.34 0.99
115_S 118_S 1.338 0.99
156_R 273_D 1.337 0.99
169_C 236_V 1.326 0.99
277_E 281_I 1.325 0.99
72_D 75_E 1.322 0.99
156_R 271_C 1.321 0.99
169_C 255_C 1.31 0.99
47_F 84_T 1.297 0.99
283_A 286_Q 1.286 0.99
226_V 237_A 1.27 0.99
91_S 122_G 1.268 0.99
96_L 284_F 1.265 0.99
114_S 118_S 1.265 0.99
245_Q 249_E 1.258 0.99
17_A 41_I 1.257 0.99
14_F 18_A 1.256 0.99
135_D 140_D 1.253 0.99
116_F 287_W 1.252 0.99
285_R 289_L 1.248 0.99
39_H 42_K 1.243 0.98
105_A 129_A 1.243 0.98
247_E 252_R 1.232 0.98
158_E 271_C 1.226 0.98
169_C 173_L 1.224 0.98
117_N 190_T 1.221 0.98
18_A 53_F 1.218 0.98
14_F 53_F 1.216 0.98
71_L 75_E 1.214 0.98
68_S 71_L 1.209 0.98
72_D 83_A 1.202 0.98
97_T 128_Q 1.197 0.98
32_V 36_A 1.196 0.98
146_F 270_V 1.194 0.98
228_Q 231_I 1.193 0.98
38_S 42_K 1.192 0.98
136_K 144_A 1.191 0.98
14_F 52_L 1.189 0.98
119_A 287_W 1.189 0.98
23_F 60_L 1.188 0.98
12_R 81_T 1.186 0.98
62_L 66_G 1.184 0.98
241_N 245_Q 1.182 0.98
143_V 269_L 1.182 0.98
204_T 209_L 1.179 0.98
255_C 258_N 1.176 0.98
17_A 26_A 1.173 0.98
135_D 138_A 1.165 0.97
181_K 185_D 1.163 0.97
220_F 226_V 1.156 0.97
56_R 61_L 1.151 0.97
79_Q 82_E 1.149 0.97
148_G 268_Y 1.142 0.97
137_L 154_G 1.129 0.97
16_A 26_A 1.129 0.97
168_V 244_A 1.128 0.97
117_N 217_G 1.127 0.97
271_C 285_R 1.107 0.96
282_A 286_Q 1.106 0.96
170_S 233_G 1.099 0.96
163_E 242_V 1.098 0.96
40_Q 43_S 1.098 0.96
119_A 290_A 1.086 0.96
167_P 236_V 1.085 0.96
11_L 73_I 1.084 0.96
157_V 270_V 1.08 0.95
114_S 232_H 1.079 0.95
9_N 12_R 1.078 0.95
32_V 37_V 1.071 0.95
169_C 174_L 1.069 0.95
286_Q 289_L 1.067 0.95
120_Y 283_A 1.066 0.95
159_K 268_Y 1.066 0.95
68_S 72_D 1.065 0.95
179_P 254_V 1.063 0.95
228_Q 232_H 1.061 0.95
116_F 120_Y 1.06 0.95
53_F 60_L 1.057 0.95
81_T 85_R 1.054 0.95
18_A 66_G 1.053 0.95
39_H 43_S 1.048 0.94
7_P 10_A 1.046 0.94
220_F 229_A 1.044 0.94
76_I 79_Q 1.04 0.94
99_S 146_F 1.032 0.94
75_E 82_E 1.032 0.94
272_H 275_Q 1.031 0.94
166_L 255_C 1.031 0.94
246_S 250_A 1.028 0.94
227_L 231_I 1.021 0.93
69_Y 73_I 1.015 0.93
98_V 143_V 1.004 0.93
173_L 190_T 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fzvA40.95411000.193Contact Map0.715
2esnA40.95411000.194Contact Map0.761
1uthA10.96391000.198Contact Map0.751
3szpA20.93441000.2Contact Map0.774
3hhgA80.98361000.2Contact Map0.929
3fxqA20.95741000.203Contact Map0.79
1ixcA20.92461000.204Contact Map0.763
1al3A10.95741000.218Contact Map0.725
2h9bA20.95741000.218Contact Map0.75
2h98A20.95081000.219Contact Map0.746
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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