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YHJC - Uncharacterized HTH-type transcriptional regulator YhjC
UniProt: P37641 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12247
Length: 299 (295)
Sequences: 37228
Seq/Len: 126.20
YHJC
Paralog alert: 0.88 [within 20: 0.50] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_D 75_N 3.749 1.00
16_L 25_F 3.42 1.00
156_R 291_A 2.612 1.00
97_D 139_F 2.48 1.00
232_G 239_I 2.466 1.00
21_R 24_D 2.401 1.00
68_R 82_L 2.337 1.00
162_T 243_R 2.308 1.00
15_E 70_K 2.253 1.00
180_S 183_D 2.224 1.00
12_K 25_F 2.182 1.00
93_K 122_E 2.178 1.00
95_R 124_E 2.168 1.00
72_V 76_L 2.141 1.00
113_E 293_V 2.126 1.00
93_K 124_E 2.125 1.00
157_P 160_K 2.113 1.00
171_Y 187_H 2.107 1.00
160_K 268_S 2.093 1.00
14_A 58_L 2.093 1.00
229_L 249_A 2.06 1.00
68_R 75_N 2.05 1.00
11_I 66_Y 2.011 1.00
9_L 36_Q 1.989 1.00
19_F 37_I 1.988 1.00
46_T 61_E 1.976 1.00
66_Y 70_K 1.956 1.00
157_P 268_S 1.925 1.00
12_K 16_L 1.89 1.00
11_I 15_E 1.882 1.00
11_I 70_K 1.877 1.00
12_K 15_E 1.873 1.00
113_E 289_W 1.866 1.00
190_V 237_G 1.85 1.00
50_Q 57_K 1.841 1.00
114_F 121_I 1.84 1.00
9_L 33_V 1.833 1.00
65_Y 79_L 1.825 1.00
233_L 249_A 1.778 1.00
164_V 243_R 1.77 1.00
14_A 66_Y 1.752 1.00
60_P 63_M 1.707 1.00
188_A 219_M 1.701 1.00
233_L 254_R 1.695 1.00
11_I 69_A 1.69 1.00
15_E 25_F 1.681 1.00
64_T 82_L 1.679 1.00
10_F 66_Y 1.679 1.00
114_F 286_F 1.668 1.00
20_S 30_K 1.631 1.00
11_I 73_L 1.605 1.00
9_L 28_L 1.604 1.00
16_L 21_R 1.603 1.00
89_S 120_G 1.597 1.00
160_K 266_P 1.59 1.00
18_S 21_R 1.589 1.00
29_P 32_S 1.583 1.00
155_A 270_S 1.536 1.00
68_R 78_E 1.502 1.00
190_V 228_Y 1.491 1.00
72_V 79_L 1.482 1.00
6_A 39_A 1.47 1.00
12_K 26_F 1.467 1.00
113_E 117_L 1.453 1.00
47_Q 50_Q 1.448 1.00
104_K 226_E 1.445 1.00
164_V 257_E 1.436 1.00
141_C 283_V 1.428 1.00
6_A 36_Q 1.415 1.00
4_I 76_L 1.409 1.00
6_A 43_Q 1.408 1.00
187_H 238_I 1.397 0.99
63_M 67_Q 1.39 0.99
154_I 275_Q 1.38 0.99
38_Q 42_H 1.373 0.99
154_I 273_Y 1.36 0.99
65_Y 80_D 1.359 0.99
113_E 116_Y 1.352 0.99
167_A 258_V 1.34 0.99
131_P 142_V 1.34 0.99
91_S 120_G 1.335 0.99
247_R 251_R 1.334 0.99
177_Y 256_I 1.332 0.99
68_R 71_D 1.331 0.99
133_D 136_H 1.324 0.99
167_A 238_I 1.315 0.99
279_L 283_V 1.313 0.99
285_L 288_Q 1.312 0.99
271_L 287_M 1.306 0.99
287_M 291_A 1.303 0.99
249_A 254_R 1.302 0.99
167_A 171_Y 1.3 0.99
112_S 116_Y 1.294 0.99
228_Y 239_I 1.293 0.99
156_R 273_Y 1.265 0.99
43_Q 80_D 1.26 0.99
222_V 228_Y 1.251 0.99
114_F 289_W 1.251 0.99
115_L 188_A 1.241 0.98
94_L 286_F 1.238 0.98
35_R 38_Q 1.235 0.98
10_F 14_A 1.234 0.98
243_R 247_R 1.232 0.98
13_V 37_I 1.23 0.98
257_E 260_P 1.228 0.98
117_L 289_W 1.223 0.98
67_Q 71_D 1.217 0.98
95_R 126_S 1.206 0.98
103_A 127_S 1.205 0.98
230_T 233_L 1.205 0.98
34_S 38_Q 1.202 0.98
115_L 219_M 1.202 0.98
10_F 49_L 1.202 0.98
28_L 32_S 1.198 0.98
14_A 49_L 1.192 0.98
144_R 272_V 1.188 0.98
8_Q 77_S 1.184 0.98
68_R 79_L 1.184 0.98
52_T 57_K 1.183 0.98
75_N 78_E 1.181 0.98
58_L 62_G 1.179 0.98
64_T 67_Q 1.172 0.98
19_F 56_V 1.17 0.97
141_C 271_L 1.169 0.97
10_F 48_L 1.169 0.97
13_V 22_A 1.151 0.97
176_G 183_D 1.146 0.97
273_Y 287_M 1.145 0.97
12_K 22_A 1.129 0.97
161_L 244_I 1.121 0.97
179_Q 183_D 1.119 0.96
284_N 288_Q 1.118 0.96
155_A 272_V 1.116 0.96
288_Q 291_A 1.115 0.96
7_M 69_A 1.114 0.96
165_N 238_I 1.105 0.96
146_G 270_S 1.102 0.96
168_S 235_G 1.098 0.96
117_L 292_G 1.094 0.96
112_S 234_A 1.093 0.96
5_H 8_Q 1.088 0.96
230_T 234_A 1.085 0.96
243_R 257_E 1.084 0.96
157_P 270_S 1.079 0.95
166_C 246_V 1.079 0.95
118_H 285_L 1.076 0.95
36_Q 39_A 1.072 0.95
64_T 68_R 1.068 0.95
49_L 56_V 1.067 0.95
114_F 118_H 1.066 0.95
124_E 221_T 1.063 0.95
188_A 217_G 1.062 0.95
72_V 75_N 1.058 0.95
77_S 81_G 1.054 0.95
35_R 39_A 1.052 0.95
71_D 78_E 1.048 0.94
229_L 233_L 1.045 0.94
28_L 33_V 1.045 0.94
248_E 252_A 1.041 0.94
171_Y 188_A 1.034 0.94
65_Y 69_A 1.033 0.94
14_A 62_G 1.007 0.93
274_P 277_R 1.007 0.93
169_P 254_R 1.007 0.93
97_D 144_R 1.004 0.93
96_I 141_C 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3szpA20.97321000.103Contact Map0.783
3mz1A40.98661000.107Contact Map0.78
3hhgA80.98661000.11Contact Map0.928
1ixcA20.97321000.11Contact Map0.762
2esnA40.97991000.113Contact Map0.763
3fzvA40.98331000.113Contact Map0.708
1uthA10.97661000.117Contact Map0.751
2h98A20.97991000.118Contact Map0.723
3fxqA20.97321000.12Contact Map0.783
1al3A10.98331000.12Contact Map0.738
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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