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OPENSEQ.org
XAPR - HTH-type transcriptional regulator XapR
UniProt: P23841 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11146
Length: 294 (287)
Sequences: 37546
Seq/Len: 130.82
XAPR
Paralog alert: 0.87 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: AAER ABGR ALLS CBL CYNR CYSB DMLR DSDC GCVA HCAR HDFR ICIA ILVY LEUO LRHA LYSR METR NAC NHAR OXYR PERR TDCA TTDR XAPR YAFC YAHB YBDO YBEF YBHD YCAN YCJZ YDCI YDHB YEEY YEIE YFER YFIE YGFI YHAJ YHJC YIAU YIDZ YJIE YNEJ YNFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
76_R 80_N 3.853 1.00
21_E 30_R 3.534 1.00
238_V 245_T 2.608 1.00
102_G 147_L 2.509 1.00
26_R 29_A 2.46 1.00
73_E 87_R 2.421 1.00
20_E 75_R 2.343 1.00
17_A 30_R 2.27 1.00
98_R 127_D 2.242 1.00
100_E 129_L 2.228 1.00
77_L 81_A 2.21 1.00
98_R 129_L 2.177 1.00
73_E 80_N 2.155 1.00
19_A 63_L 2.148 1.00
16_L 71_M 2.089 1.00
24_F 42_I 2.079 1.00
166_R 169_E 2.058 1.00
171_A 249_D 2.044 1.00
14_Y 41_H 2.03 1.00
71_M 75_R 2.026 1.00
51_T 66_A 2.009 1.00
17_A 21_E 1.992 1.00
169_E 271_D 1.981 1.00
180_H 196_E 1.963 1.00
14_Y 38_L 1.951 1.00
189_P 192_A 1.935 1.00
119_F 126_V 1.932 1.00
17_A 20_E 1.926 1.00
16_L 75_R 1.923 1.00
16_L 20_E 1.916 1.00
55_I 62_V 1.891 1.00
70_L 84_V 1.876 1.00
166_R 271_D 1.831 1.00
65_H 68_K 1.796 1.00
19_A 71_M 1.789 1.00
15_F 71_M 1.728 1.00
69_I 87_R 1.727 1.00
16_L 74_S 1.72 1.00
20_E 30_R 1.712 1.00
199_V 243_G 1.697 1.00
34_S 37_P 1.69 1.00
25_G 35_Q 1.676 1.00
21_E 26_R 1.667 1.00
138_Q 150_G 1.66 1.00
94_G 125_N 1.647 1.00
23_H 26_R 1.644 1.00
14_Y 33_M 1.623 1.00
16_L 78_L 1.609 1.00
118_R 291_A 1.584 1.00
140_A 144_R 1.58 1.00
235_L 255_N 1.572 1.00
119_F 288_L 1.564 1.00
176_M 262_R 1.564 1.00
73_E 83_N 1.545 1.00
185_F 192_A 1.52 1.00
77_L 84_V 1.503 1.00
17_A 31_L 1.503 1.00
141_L 146_E 1.497 1.00
52_Q 55_I 1.496 1.00
11_L 41_H 1.49 1.00
164_S 273_Y 1.488 1.00
68_K 72_E 1.486 1.00
11_L 48_Q 1.472 1.00
70_L 85_L 1.465 1.00
9_L 81_A 1.464 1.00
11_L 44_E 1.463 1.00
208_W 212_Q 1.456 1.00
199_V 234_V 1.455 1.00
196_E 244_I 1.437 1.00
239_S 255_N 1.428 1.00
109_W 232_Q 1.426 1.00
118_R 121_R 1.407 0.99
96_A 125_N 1.393 0.99
149_A 285_M 1.391 0.99
118_R 122_E 1.386 0.99
43_K 47_N 1.385 0.99
73_E 76_R 1.346 0.99
163_T 276_Y 1.345 0.99
8_D 11_L 1.342 0.99
234_V 245_T 1.33 0.99
142_L 150_G 1.327 0.99
18_V 42_I 1.318 0.99
169_E 269_P 1.312 0.99
117_R 121_R 1.307 0.99
40_I 43_K 1.295 0.99
48_Q 85_L 1.289 0.99
228_V 234_V 1.288 0.99
197_Y 223_V 1.277 0.99
165_L 293_T 1.276 0.99
15_F 19_A 1.275 0.99
39_S 43_K 1.263 0.99
73_E 84_V 1.263 0.99
215_C 220_F 1.26 0.99
133_K 137_M 1.259 0.99
141_L 147_L 1.256 0.99
173_L 249_D 1.256 0.99
63_L 67_G 1.249 0.99
72_E 76_R 1.244 0.98
181_H 196_E 1.244 0.98
100_E 131_R 1.237 0.98
69_I 72_E 1.236 0.98
15_F 54_F 1.235 0.98
274_I 289_L 1.23 0.98
149_A 274_I 1.229 0.98
33_M 37_P 1.228 0.98
163_T 278_T 1.227 0.98
57_H 62_V 1.224 0.98
99_I 288_L 1.22 0.98
13_R 82_N 1.217 0.98
262_R 265_K 1.217 0.98
236_A 239_S 1.208 0.98
15_F 53_L 1.205 0.98
18_V 27_A 1.205 0.98
80_N 83_N 1.204 0.98
176_M 180_H 1.201 0.98
165_L 276_Y 1.198 0.98
41_H 44_E 1.184 0.98
19_A 54_F 1.183 0.98
281_V 285_M 1.18 0.98
143_E 161_G 1.172 0.98
197_Y 225_I 1.17 0.97
120_L 197_Y 1.169 0.97
17_A 27_A 1.163 0.97
24_F 61_V 1.151 0.97
235_L 239_S 1.142 0.97
176_M 244_I 1.141 0.97
119_F 123_N 1.138 0.97
287_K 290_A 1.129 0.97
178_E 258_G 1.125 0.97
10_K 13_R 1.124 0.97
69_I 73_E 1.123 0.97
117_R 240_M 1.119 0.96
12_L 74_S 1.116 0.96
40_I 44_E 1.115 0.96
255_N 259_V 1.114 0.96
236_A 240_M 1.114 0.96
82_N 86_A 1.083 0.96
33_M 38_L 1.079 0.95
77_L 80_N 1.078 0.95
54_F 61_V 1.071 0.95
249_D 253_Q 1.069 0.95
166_R 273_Y 1.066 0.95
76_R 83_N 1.059 0.95
14_Y 31_L 1.052 0.95
108_M 132_E 1.044 0.94
101_L 149_A 1.041 0.94
19_A 67_G 1.038 0.94
164_S 275_V 1.033 0.94
119_F 291_A 1.031 0.94
18_V 54_F 1.03 0.94
286_V 290_A 1.028 0.94
228_V 237_M 1.027 0.94
70_L 74_S 1.027 0.94
276_Y 289_L 1.026 0.94
114_P 240_M 1.026 0.94
129_L 227_E 1.017 0.93
18_V 24_F 1.005 0.93
133_K 141_L 1.003 0.93
239_S 259_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2h98A20.97281000.125Contact Map0.79
1ixcA20.97621000.129Contact Map0.76
2esnA40.99321000.131Contact Map0.763
3fzvA40.9831000.133Contact Map0.736
2h9bA20.97281000.133Contact Map0.781
1al3A10.97961000.136Contact Map0.799
1uthA10.99321000.139Contact Map0.762
3fxqA20.97621000.14Contact Map0.786
3hhgA80.97281000.17Contact Map0.921
3szpA20.96261000.172Contact Map0.742
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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