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OPENSEQ.org

YBBO - Uncharacterized oxidoreductase YbbO
UniProt: P0AFP4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13262
Length: 269 (233)
Sequences: 50994
Seq/Len: 218.86

YBBO
Paralog alert: 0.88 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: BDCA ENTA FABG FABI FOLM HCAB HDHA IDNO KDUD SRLD UCPA YBBO YCIK YDFG YGCW YGFF YGHA YOHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
112_E 120_F 3.249 1.00
112_E 116_S 2.933 1.00
164_Y 168_A 2.86 1.00
69_S 72_S 2.744 1.00
143_M 170_S 2.731 1.00
81_I 132_A 2.432 1.00
140_R 183_K 2.432 1.00
18_V 90_G 2.355 1.00
29_L 33_L 2.306 1.00
74_D 128_R 2.236 1.00
126_T 173_L 2.223 1.00
145_S 167_E 2.207 1.00
134_L 180_S 2.189 1.00
193_R 221_G 2.174 1.00
34_E 227_D 2.165 1.00
49_P 53_E 2.145 1.00
93_N 143_M 2.127 1.00
116_S 120_F 2.07 1.00
34_E 230_R 2.003 1.00
130_L 177_L 1.972 1.00
90_G 233_F 1.962 1.00
77_A 129_L 1.929 1.00
70_P 108_R 1.921 1.00
17_S 41_H 1.877 1.00
45_G 65_I 1.872 1.00
27_I 192_I 1.854 1.00
34_E 38_Q 1.849 1.00
122_A 166_L 1.776 1.00
118_N 162_S 1.759 1.00
15_Q 40_F 1.745 1.00
31_S 229_V 1.725 1.00
79_E 83_L 1.719 1.00
170_S 186_L 1.686 1.00
48_K 51_D 1.657 1.00
24_S 46_C 1.651 1.00
23_C 44_A 1.619 1.00
119_F 165_A 1.601 1.00
38_Q 230_R 1.597 1.00
52_V 62_G 1.578 1.00
33_L 58_M 1.573 1.00
43_L 80_V 1.572 1.00
35_L 233_F 1.569 1.00
45_G 76_A 1.56 1.00
78_D 82_A 1.548 1.00
34_E 37_R 1.538 1.00
115_F 119_F 1.53 1.00
40_F 90_G 1.53 1.00
140_R 185_S 1.52 1.00
29_L 55_M 1.516 1.00
43_L 84_T 1.511 1.00
17_S 87_C 1.508 1.00
61_T 83_L 1.5 1.00
92_F 144_T 1.494 1.00
65_I 72_S 1.49 1.00
108_R 124_Q 1.483 1.00
49_P 64_L 1.47 1.00
75_R 79_E 1.47 1.00
107_S 110_Q 1.456 1.00
74_D 78_D 1.445 1.00
91_I 125_L 1.424 1.00
79_E 82_A 1.418 1.00
18_V 35_L 1.407 0.99
25_S 195_R 1.406 0.99
73_V 125_L 1.396 0.99
70_P 124_Q 1.37 0.99
65_I 76_A 1.352 0.99
30_E 223_E 1.327 0.99
145_S 186_L 1.32 0.99
63_V 79_E 1.307 0.99
70_P 74_D 1.306 0.99
32_A 44_A 1.303 0.99
72_S 75_R 1.302 0.99
93_N 126_T 1.291 0.99
170_S 184_V 1.264 0.99
132_A 136_H 1.262 0.99
120_F 124_Q 1.26 0.99
187_I 229_V 1.258 0.99
30_E 33_L 1.257 0.99
126_T 141_I 1.252 0.99
18_V 40_F 1.228 0.98
35_L 40_F 1.224 0.98
173_L 184_V 1.213 0.98
192_I 220_L 1.208 0.98
88_L 129_L 1.192 0.98
17_S 43_L 1.191 0.98
33_L 37_R 1.189 0.98
34_E 226_V 1.189 0.98
104_S 134_L 1.174 0.98
227_D 239_K 1.169 0.97
41_H 61_T 1.163 0.97
115_F 120_F 1.163 0.97
99_M 113_Q 1.154 0.97
25_S 51_D 1.153 0.97
91_I 129_L 1.149 0.97
38_Q 234_I 1.141 0.97
159_Y 163_K 1.127 0.97
71_E 75_R 1.12 0.96
53_E 57_S 1.111 0.96
109_A 113_Q 1.11 0.96
87_C 136_H 1.107 0.96
97_F 117_A 1.104 0.96
29_L 58_M 1.1 0.96
108_R 120_F 1.098 0.96
56_N 62_G 1.094 0.96
94_N 144_T 1.092 0.96
75_R 78_D 1.091 0.96
63_V 76_A 1.069 0.95
101_G 110_Q 1.069 0.95
35_L 230_R 1.061 0.95
123_H 169_W 1.059 0.95
19_L 76_A 1.058 0.95
185_S 232_A 1.058 0.95
31_S 226_V 1.058 0.95
61_T 84_T 1.057 0.95
102_P 105_T 1.056 0.95
126_T 169_W 1.053 0.95
150_L 188_E 1.046 0.94
68_D 113_Q 1.043 0.94
144_T 229_V 1.035 0.94
16_K 89_Y 1.034 0.94
53_E 56_N 1.029 0.94
67_L 121_G 1.024 0.93
122_A 143_M 1.024 0.93
220_L 242_Y 1.022 0.93
44_A 60_F 1.021 0.93
149_G 167_E 1.019 0.93
34_E 223_E 1.018 0.93
30_E 222_P 1.011 0.93
31_S 92_F 1.002 0.92
111_M 120_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4j2hA10.92941000.222Contact Map0.733
2c07A10.92941000.223Contact Map0.754
1vl8A20.93681000.224Contact Map0.787
1zemA80.89221000.229Contact Map0.836
3cxtA10.9481000.229Contact Map0.707
1ulsA80.90331000.23Contact Map0.841
4iboA40.92571000.23Contact Map0.825
3op4A20.91081000.231Contact Map0.73
1xq1A10.95171000.231Contact Map0.674
1iy8A80.93311000.232Contact Map0.861

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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