May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org

IDNO - Gluconate 5-dehydrogenase
UniProt: P0A9P9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12540
Length: 254 (248)
Sequences: 50486
Seq/Len: 203.57

IDNO
Paralog alert: 0.89 [within 20: 0.48] - ratio of genomes with paralogs
Cluster includes: BDCA ENTA FABG FABI FOLM HCAB HDHA IDNO KDUD SRLD UCPA YBBO YCIK YDFG YGCW YGFF YGHA YOHF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
111_N 119_T 3.181 1.00
111_N 115_A 2.872 1.00
69_H 72_E 2.723 1.00
163_G 167_M 2.721 1.00
142_N 169_T 2.544 1.00
139_K 182_Q 2.345 1.00
81_E 131_H 2.325 1.00
12_I 89_V 2.28 1.00
23_F 27_T 2.266 1.00
74_D 127_A 2.191 1.00
43_A 47_E 2.183 1.00
125_S 172_M 2.164 1.00
144_C 166_K 2.142 1.00
133_V 179_H 2.141 1.00
187_A 243_L 2.132 1.00
192_K 220_D 2.113 1.00
28_G 226_G 2.033 1.00
89_V 232_S 1.986 1.00
92_N 142_N 1.97 1.00
115_A 119_T 1.966 1.00
35_Q 59_Q 1.945 1.00
129_T 176_L 1.904 1.00
77_V 128_V 1.897 1.00
70_K 107_E 1.884 1.00
28_G 229_V 1.841 1.00
226_G 235_A 1.827 1.00
11_N 35_Q 1.824 1.00
39_N 65_F 1.823 1.00
28_G 32_Y 1.817 1.00
242_H 245_F 1.774 1.00
21_I 191_F 1.758 1.00
27_T 52_K 1.756 1.00
121_V 165_V 1.718 1.00
117_N 161_S 1.711 1.00
25_L 228_A 1.707 1.00
23_F 52_K 1.678 1.00
23_F 49_A 1.677 1.00
79_H 83_D 1.667 1.00
169_T 185_G 1.663 1.00
227_A 244_L 1.653 1.00
18_A 40_D 1.603 1.00
17_S 38_I 1.588 1.00
61_V 83_D 1.574 1.00
37_I 84_I 1.563 1.00
42_T 45_R 1.557 1.00
78_E 82_K 1.55 1.00
118_Q 164_A 1.547 1.00
29_L 232_S 1.544 1.00
32_Y 229_V 1.532 1.00
39_N 76_A 1.532 1.00
46_A 62_A 1.531 1.00
37_I 80_I 1.53 1.00
114_I 118_Q 1.502 1.00
28_G 31_K 1.499 1.00
75_A 79_H 1.488 1.00
74_D 78_E 1.474 1.00
65_F 72_E 1.463 1.00
34_A 89_V 1.458 1.00
106_P 109_E 1.453 1.00
11_N 86_P 1.45 1.00
139_K 184_N 1.438 1.00
90_L 124_V 1.434 1.00
91_V 143_I 1.425 1.00
79_H 82_K 1.414 1.00
12_I 29_L 1.403 0.99
107_E 123_L 1.403 0.99
47_E 51_E 1.395 0.99
43_A 64_P 1.391 0.99
219_G 238_F 1.389 0.99
19_Q 194_E 1.362 0.99
50_V 54_H 1.327 0.99
70_K 123_L 1.319 0.99
9_G 34_A 1.314 0.99
73_I 124_V 1.314 0.99
65_F 76_A 1.297 0.99
63_A 79_H 1.286 0.99
72_E 75_A 1.286 0.99
50_V 62_A 1.271 0.99
70_K 74_D 1.265 0.99
186_I 228_A 1.265 0.99
144_C 185_G 1.258 0.99
92_N 125_S 1.244 0.98
169_T 183_V 1.241 0.98
119_T 123_L 1.23 0.98
35_Q 58_I 1.226 0.98
191_F 219_G 1.221 0.98
227_A 246_V 1.221 0.98
26_A 38_I 1.219 0.98
125_S 140_V 1.216 0.98
131_H 135_R 1.214 0.98
12_I 34_A 1.214 0.98
7_L 34_A 1.213 0.98
29_L 34_A 1.211 0.98
24_L 27_T 1.208 0.98
24_L 222_Q 1.195 0.98
87_I 128_V 1.185 0.98
51_E 55_Q 1.169 0.97
172_M 183_V 1.163 0.97
61_V 84_I 1.152 0.97
11_N 37_I 1.151 0.97
71_H 75_A 1.15 0.97
27_T 31_K 1.149 0.97
51_E 54_H 1.144 0.97
28_G 225_I 1.127 0.97
107_E 119_T 1.124 0.97
103_T 133_V 1.116 0.96
90_L 128_V 1.11 0.96
98_R 112_D 1.109 0.96
114_I 119_T 1.109 0.96
31_K 56_E 1.105 0.96
149_E 245_F 1.095 0.96
19_Q 45_R 1.092 0.96
96_I 116_V 1.09 0.96
100_H 109_E 1.085 0.96
63_A 76_A 1.079 0.95
47_E 50_V 1.076 0.95
108_Q 112_D 1.068 0.95
75_A 78_E 1.068 0.95
86_P 135_R 1.057 0.95
122_F 168_L 1.056 0.95
143_I 228_A 1.044 0.94
93_N 143_I 1.042 0.94
185_G 243_L 1.041 0.94
13_L 76_A 1.037 0.94
101_P 104_E 1.031 0.94
110_W 119_T 1.031 0.94
68_T 112_D 1.029 0.94
230_F 239_V 1.014 0.93
35_Q 61_V 1.013 0.93
166_K 243_L 1.011 0.93
158_Y 162_K 1.01 0.93
121_V 142_N 1.008 0.93
29_L 229_V 1.007 0.93
125_S 168_L 1.006 0.93
28_G 222_Q 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4g81D411000.086Contact Map0.801
4iboA411000.092Contact Map0.827
4j2hA111000.093Contact Map0.736
1vl8A20.99611000.096Contact Map0.79
2ae2A211000.101Contact Map0.742
3op4A20.97641000.103Contact Map0.756
4egfA80.99611000.103Contact Map0.805
3v8bA411000.106Contact Map0.83
2zatA411000.108Contact Map0.839
3cxtA111000.109Contact Map0.692

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0439 seconds.