| UniProt: | P0AET8 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10425 | ||
| Length: | 255 (244) | ||
| Sequences: | 48092 | ||
| Seq/Len: | 197.10 |
| HDHA
Paralog alert: 0.89 [within 20: 0.47] - ratio of genomes with paralogs Cluster includes: BDCA ENTA FABG FABI FOLM HCAB HDHA IDNO KDUD SRLD UCPA YBBO YCIK YDFG YGCW YGFF YGHA YOHF |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 112_R | 120_F | 3.15 | 1.00 | |
| 112_R | 116_E | 2.846 | 1.00 | |
| 71_S | 74_E | 2.745 | 1.00 | |
| 164_A | 168_H | 2.619 | 1.00 | |
| 143_T | 170_V | 2.506 | 1.00 | |
| 140_V | 183_R | 2.371 | 1.00 | |
| 25_K | 29_I | 2.305 | 1.00 | |
| 14_A | 91_I | 2.3 | 1.00 | |
| 83_I | 132_E | 2.29 | 1.00 | |
| 45_A | 49_N | 2.23 | 1.00 | |
| 126_S | 173_M | 2.203 | 1.00 | |
| 134_E | 180_K | 2.175 | 1.00 | |
| 188_A | 243_I | 2.169 | 1.00 | |
| 76_S | 128_L | 2.144 | 1.00 | |
| 145_T | 167_S | 2.141 | 1.00 | |
| 193_L | 220_Q | 2.114 | 1.00 | |
| 91_I | 232_C | 1.991 | 1.00 | |
| 30_T | 226_N | 1.971 | 1.00 | |
| 72_E | 108_M | 1.942 | 1.00 | |
| 94_N | 143_T | 1.941 | 1.00 | |
| 116_E | 120_F | 1.933 | 1.00 | |
| 37_S | 61_Q | 1.932 | 1.00 | |
| 226_N | 235_A | 1.904 | 1.00 | |
| 79_A | 129_V | 1.898 | 1.00 | |
| 130_A | 177_L | 1.866 | 1.00 | |
| 41_S | 67_C | 1.82 | 1.00 | |
| 30_T | 229_L | 1.819 | 1.00 | |
| 242_Q | 245_T | 1.813 | 1.00 | |
| 30_T | 34_A | 1.812 | 1.00 | |
| 13_C | 37_S | 1.792 | 1.00 | |
| 27_I | 228_A | 1.749 | 1.00 | |
| 118_N | 162_S | 1.726 | 1.00 | |
| 23_I | 192_I | 1.723 | 1.00 | |
| 227_A | 244_L | 1.72 | 1.00 | |
| 122_F | 166_A | 1.711 | 1.00 | |
| 29_I | 54_E | 1.687 | 1.00 | |
| 170_V | 186_G | 1.683 | 1.00 | |
| 25_K | 51_V | 1.642 | 1.00 | |
| 81_F | 85_K | 1.639 | 1.00 | |
| 25_K | 54_E | 1.621 | 1.00 | |
| 19_A | 40_V | 1.608 | 1.00 | |
| 80_D | 84_S | 1.598 | 1.00 | |
| 20_G | 42_D | 1.581 | 1.00 | |
| 48_A | 64_A | 1.565 | 1.00 | |
| 119_V | 165_A | 1.564 | 1.00 | |
| 31_F | 232_C | 1.559 | 1.00 | |
| 39_V | 82_A | 1.544 | 1.00 | |
| 34_A | 229_L | 1.538 | 1.00 | |
| 44_N | 47_A | 1.529 | 1.00 | |
| 63_F | 85_K | 1.525 | 1.00 | |
| 115_Y | 119_V | 1.517 | 1.00 | |
| 41_S | 78_L | 1.501 | 1.00 | |
| 39_V | 86_L | 1.499 | 1.00 | |
| 219_G | 238_W | 1.498 | 1.00 | |
| 77_A | 81_F | 1.489 | 1.00 | |
| 30_T | 33_T | 1.48 | 1.00 | |
| 67_C | 74_E | 1.475 | 1.00 | |
| 36_A | 91_I | 1.47 | 1.00 | |
| 13_C | 88_K | 1.462 | 1.00 | |
| 76_S | 80_D | 1.46 | 1.00 | |
| 107_P | 110_D | 1.455 | 1.00 | |
| 14_A | 31_F | 1.442 | 1.00 | |
| 92_L | 125_L | 1.438 | 1.00 | |
| 45_A | 66_R | 1.398 | 0.99 | |
| 81_F | 84_S | 1.381 | 0.99 | |
| 140_V | 185_N | 1.376 | 0.99 | |
| 93_V | 144_I | 1.371 | 0.99 | |
| 108_M | 124_H | 1.37 | 0.99 | |
| 49_N | 53_D | 1.364 | 0.99 | |
| 52_V | 56_Q | 1.334 | 0.99 | |
| 11_G | 36_A | 1.326 | 0.99 | |
| 187_I | 228_A | 1.321 | 0.99 | |
| 21_A | 195_D | 1.305 | 0.99 | |
| 75_L | 125_L | 1.301 | 0.99 | |
| 67_C | 78_L | 1.294 | 0.99 | |
| 192_I | 219_G | 1.293 | 0.99 | |
| 72_E | 124_H | 1.287 | 0.99 | |
| 74_E | 77_A | 1.281 | 0.99 | |
| 227_A | 246_V | 1.27 | 0.99 | |
| 145_T | 186_G | 1.259 | 0.99 | |
| 31_F | 36_A | 1.258 | 0.99 | |
| 52_V | 64_A | 1.255 | 0.99 | |
| 28_A | 40_V | 1.253 | 0.99 | |
| 37_S | 60_G | 1.245 | 0.98 | |
| 65_C | 81_F | 1.238 | 0.98 | |
| 120_F | 124_H | 1.237 | 0.98 | |
| 72_E | 76_S | 1.23 | 0.98 | |
| 94_N | 126_S | 1.226 | 0.98 | |
| 9_L | 36_A | 1.211 | 0.98 | |
| 89_V | 129_V | 1.202 | 0.98 | |
| 173_M | 184_V | 1.2 | 0.98 | |
| 132_E | 136_N | 1.197 | 0.98 | |
| 170_V | 184_V | 1.191 | 0.98 | |
| 126_S | 141_I | 1.171 | 0.98 | |
| 53_D | 57_Q | 1.167 | 0.97 | |
| 53_D | 56_Q | 1.167 | 0.97 | |
| 14_A | 36_A | 1.163 | 0.97 | |
| 29_I | 33_T | 1.161 | 0.97 | |
| 73_Q | 77_A | 1.16 | 0.97 | |
| 26_E | 29_I | 1.134 | 0.97 | |
| 108_M | 120_F | 1.133 | 0.97 | |
| 26_E | 222_Q | 1.131 | 0.97 | |
| 150_E | 245_T | 1.117 | 0.96 | |
| 92_L | 129_V | 1.112 | 0.96 | |
| 13_C | 39_V | 1.102 | 0.96 | |
| 115_Y | 120_F | 1.097 | 0.96 | |
| 21_A | 47_A | 1.096 | 0.96 | |
| 63_F | 86_L | 1.096 | 0.96 | |
| 33_T | 58_L | 1.094 | 0.96 | |
| 30_T | 225_A | 1.09 | 0.96 | |
| 100_G | 113_R | 1.087 | 0.96 | |
| 98_G | 117_L | 1.081 | 0.95 | |
| 102_K | 110_D | 1.062 | 0.95 | |
| 230_F | 239_V | 1.061 | 0.95 | |
| 186_G | 243_I | 1.057 | 0.95 | |
| 88_K | 136_N | 1.053 | 0.95 | |
| 77_A | 80_D | 1.052 | 0.95 | |
| 65_C | 78_L | 1.05 | 0.94 | |
| 49_N | 52_V | 1.042 | 0.94 | |
| 109_A | 113_R | 1.041 | 0.94 | |
| 111_F | 120_F | 1.04 | 0.94 | |
| 144_I | 228_A | 1.035 | 0.94 | |
| 123_F | 169_L | 1.035 | 0.94 | |
| 95_N | 144_I | 1.029 | 0.94 | |
| 69_I | 121_S | 1.028 | 0.94 | |
| 167_S | 243_I | 1.021 | 0.93 | |
| 27_I | 93_V | 1.021 | 0.93 | |
| 15_I | 78_L | 1.018 | 0.93 | |
| 207_Q | 211_Q | 1.01 | 0.93 | |
| 70_T | 113_R | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1fmcA | 2 | 1 | 100 | 0.093 | Contact Map | 0.813 |
| 3gafA | 8 | 1 | 100 | 0.115 | Contact Map | 0.837 |
| 4j2hA | 1 | 0.9961 | 100 | 0.124 | Contact Map | 0.748 |
| 4iboA | 4 | 0.9961 | 100 | 0.128 | Contact Map | 0.833 |
| 4iinA | 4 | 0.9843 | 100 | 0.128 | Contact Map | 0.852 |
| 3cxtA | 1 | 1 | 100 | 0.128 | Contact Map | 0.698 |
| 1zemA | 8 | 0.9608 | 100 | 0.131 | Contact Map | 0.852 |
| 1vl8A | 2 | 0.9922 | 100 | 0.134 | Contact Map | 0.803 |
| 4bnwA | 4 | 0.9843 | 100 | 0.135 | Contact Map | 0.779 |
| 4ag3A | 4 | 0.9843 | 100 | 0.135 | Contact Map | 0.799 |
Sequence Conservation (Image Generated using WebLogo v3)