| UniProt: | Q46925 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13082 | ||
| Length: | 401 (378) | ||
| Sequences: | 33645 | ||
| Seq/Len: | 89.01 |
| CSDA
Paralog alert: 0.90 [within 20: 0.48] - ratio of genomes with paralogs Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 307_L | 386_D | 3.963 | 1.00 | |
| 154_P | 188_S | 3.569 | 1.00 | |
| 311_A | 389_V | 3.482 | 1.00 | |
| 348_Y | 394_R | 3.431 | 1.00 | |
| 40_Q | 44_S | 3.331 | 1.00 | |
| 307_L | 382_K | 2.968 | 1.00 | |
| 71_K | 287_E | 2.951 | 1.00 | |
| 303_S | 382_K | 2.942 | 1.00 | |
| 33_E | 37_E | 2.83 | 1.00 | |
| 387_A | 391_A | 2.727 | 1.00 | |
| 178_D | 181_R | 2.718 | 1.00 | |
| 111_E | 136_K | 2.601 | 1.00 | |
| 111_E | 138_V | 2.502 | 1.00 | |
| 111_E | 158_T | 2.461 | 1.00 | |
| 37_E | 41_Q | 2.434 | 1.00 | |
| 302_R | 306_T | 2.4 | 1.00 | |
| 381_T | 384_D | 2.37 | 1.00 | |
| 87_T | 93_S | 2.365 | 1.00 | |
| 344_L | 347_E | 2.357 | 1.00 | |
| 319_R | 332_D | 2.346 | 1.00 | |
| 284_A | 287_E | 2.303 | 1.00 | |
| 152_L | 155_E | 2.281 | 1.00 | |
| 150_V | 185_F | 2.276 | 1.00 | |
| 110_D | 162_R | 2.259 | 1.00 | |
| 307_L | 311_A | 2.256 | 1.00 | |
| 152_L | 156_L | 2.254 | 1.00 | |
| 311_A | 314_K | 2.19 | 1.00 | |
| 234_G | 239_L | 2.187 | 1.00 | |
| 154_P | 189_A | 2.104 | 1.00 | |
| 387_A | 390_N | 2.103 | 1.00 | |
| 71_K | 283_S | 2.08 | 1.00 | |
| 111_E | 161_S | 2.064 | 1.00 | |
| 306_T | 310_D | 2.048 | 1.00 | |
| 183_I | 193_V | 2.035 | 1.00 | |
| 337_H | 340_D | 2.006 | 1.00 | |
| 275_N | 278_G | 2.006 | 1.00 | |
| 116_V | 141_P | 2.004 | 1.00 | |
| 311_A | 386_D | 1.991 | 1.00 | |
| 70_E | 74_Q | 1.974 | 1.00 | |
| 348_Y | 391_A | 1.958 | 1.00 | |
| 106_L | 135_A | 1.927 | 1.00 | |
| 36_V | 40_Q | 1.921 | 1.00 | |
| 184_T | 188_S | 1.903 | 1.00 | |
| 180_A | 184_T | 1.896 | 1.00 | |
| 311_A | 393_D | 1.896 | 1.00 | |
| 181_R | 184_T | 1.874 | 1.00 | |
| 23_L | 388_L | 1.872 | 1.00 | |
| 141_P | 152_L | 1.865 | 1.00 | |
| 149_D | 152_L | 1.838 | 1.00 | |
| 163_I | 194_M | 1.826 | 1.00 | |
| 183_I | 187_H | 1.791 | 1.00 | |
| 218_F | 231_V | 1.783 | 1.00 | |
| 97_V | 215_F | 1.779 | 1.00 | |
| 344_L | 395_A | 1.752 | 1.00 | |
| 111_E | 160_R | 1.74 | 1.00 | |
| 154_P | 185_F | 1.732 | 1.00 | |
| 70_E | 81_D | 1.721 | 1.00 | |
| 186_A | 193_V | 1.709 | 1.00 | |
| 315_R | 393_D | 1.705 | 1.00 | |
| 37_E | 40_Q | 1.701 | 1.00 | |
| 197_G | 216_Y | 1.672 | 1.00 | |
| 140_L | 156_L | 1.669 | 1.00 | |
| 186_A | 191_M | 1.665 | 1.00 | |
| 300_W | 303_S | 1.645 | 1.00 | |
| 374_A | 388_L | 1.641 | 1.00 | |
| 150_V | 181_R | 1.637 | 1.00 | |
| 382_K | 386_D | 1.632 | 1.00 | |
| 164_L | 191_M | 1.631 | 1.00 | |
| 314_K | 393_D | 1.624 | 1.00 | |
| 67_A | 283_S | 1.62 | 1.00 | |
| 310_D | 314_K | 1.619 | 1.00 | |
| 220_G | 282_L | 1.611 | 1.00 | |
| 187_H | 212_D | 1.608 | 1.00 | |
| 300_W | 304_L | 1.605 | 1.00 | |
| 41_Q | 45_L | 1.601 | 1.00 | |
| 72_V | 231_V | 1.579 | 1.00 | |
| 311_A | 390_N | 1.578 | 1.00 | |
| 309_E | 313_A | 1.577 | 1.00 | |
| 299_S | 303_S | 1.571 | 1.00 | |
| 185_F | 189_A | 1.564 | 1.00 | |
| 151_D | 155_E | 1.556 | 1.00 | |
| 151_D | 181_R | 1.543 | 1.00 | |
| 90_T | 217_A | 1.541 | 1.00 | |
| 71_K | 290_A | 1.539 | 1.00 | |
| 164_L | 186_A | 1.533 | 1.00 | |
| 154_P | 158_T | 1.527 | 1.00 | |
| 340_D | 344_L | 1.524 | 1.00 | |
| 66_E | 70_E | 1.523 | 1.00 | |
| 229_I | 282_L | 1.521 | 1.00 | |
| 95_N | 99_Q | 1.513 | 1.00 | |
| 36_V | 44_S | 1.498 | 1.00 | |
| 390_N | 394_R | 1.483 | 1.00 | |
| 82_K | 236_S | 1.478 | 1.00 | |
| 295_N | 299_S | 1.477 | 1.00 | |
| 34_A | 284_A | 1.467 | 1.00 | |
| 39_T | 281_G | 1.467 | 1.00 | |
| 151_D | 154_P | 1.461 | 1.00 | |
| 88_R | 92_E | 1.451 | 1.00 | |
| 38_A | 284_A | 1.45 | 1.00 | |
| 168_Q | 200_G | 1.441 | 1.00 | |
| 157_I | 185_F | 1.437 | 1.00 | |
| 116_V | 139_K | 1.435 | 1.00 | |
| 138_V | 156_L | 1.435 | 1.00 | |
| 307_L | 385_V | 1.431 | 1.00 | |
| 113_I | 156_L | 1.429 | 1.00 | |
| 386_D | 390_N | 1.413 | 1.00 | |
| 154_P | 181_R | 1.407 | 0.99 | |
| 83_T | 236_S | 1.407 | 0.99 | |
| 110_D | 160_R | 1.393 | 0.99 | |
| 194_M | 217_A | 1.379 | 0.99 | |
| 71_K | 74_Q | 1.379 | 0.99 | |
| 38_A | 41_Q | 1.368 | 0.99 | |
| 34_A | 288_W | 1.361 | 0.99 | |
| 187_H | 214_D | 1.359 | 0.99 | |
| 332_D | 370_G | 1.359 | 0.99 | |
| 300_W | 382_K | 1.357 | 0.99 | |
| 93_S | 217_A | 1.357 | 0.99 | |
| 98_A | 165_A | 1.354 | 0.99 | |
| 80_D | 236_S | 1.345 | 0.99 | |
| 309_E | 329_L | 1.345 | 0.99 | |
| 107_Q | 110_D | 1.325 | 0.99 | |
| 113_I | 161_S | 1.323 | 0.99 | |
| 180_A | 210_Q | 1.321 | 0.99 | |
| 166_L | 182_A | 1.311 | 0.99 | |
| 94_I | 121_A | 1.309 | 0.99 | |
| 73_A | 81_D | 1.308 | 0.99 | |
| 190_G | 213_I | 1.307 | 0.99 | |
| 304_L | 382_K | 1.304 | 0.99 | |
| 313_A | 320_S | 1.298 | 0.99 | |
| 157_I | 191_M | 1.294 | 0.99 | |
| 319_R | 334_A | 1.288 | 0.99 | |
| 97_V | 194_M | 1.288 | 0.99 | |
| 158_T | 161_S | 1.287 | 0.99 | |
| 344_L | 348_Y | 1.284 | 0.99 | |
| 232_L | 242_M | 1.282 | 0.99 | |
| 343_T | 347_E | 1.281 | 0.99 | |
| 350_I | 391_A | 1.271 | 0.99 | |
| 296_Q | 299_S | 1.263 | 0.99 | |
| 305_A | 309_E | 1.252 | 0.99 | |
| 299_S | 302_R | 1.251 | 0.99 | |
| 143_N | 149_D | 1.24 | 0.98 | |
| 198_A | 219_S | 1.233 | 0.98 | |
| 352_L | 372_L | 1.233 | 0.98 | |
| 36_V | 43_Y | 1.224 | 0.98 | |
| 393_D | 397_E | 1.221 | 0.98 | |
| 207_D | 210_Q | 1.2 | 0.98 | |
| 311_A | 315_R | 1.189 | 0.98 | |
| 340_D | 343_T | 1.184 | 0.98 | |
| 296_Q | 300_W | 1.179 | 0.98 | |
| 215_F | 234_G | 1.165 | 0.97 | |
| 342_V | 352_L | 1.165 | 0.97 | |
| 308_A | 311_A | 1.159 | 0.97 | |
| 310_D | 313_A | 1.156 | 0.97 | |
| 383_S | 386_D | 1.154 | 0.97 | |
| 76_L | 233_Y | 1.148 | 0.97 | |
| 350_I | 388_L | 1.135 | 0.97 | |
| 101_Y | 192_V | 1.127 | 0.97 | |
| 331_F | 374_A | 1.126 | 0.97 | |
| 67_A | 71_K | 1.126 | 0.97 | |
| 345_L | 352_L | 1.113 | 0.96 | |
| 72_V | 86_W | 1.109 | 0.96 | |
| 295_N | 298_E | 1.107 | 0.96 | |
| 315_R | 389_V | 1.106 | 0.96 | |
| 77_N | 207_D | 1.106 | 0.96 | |
| 37_E | 44_S | 1.105 | 0.96 | |
| 23_L | 385_V | 1.104 | 0.96 | |
| 33_E | 36_V | 1.099 | 0.96 | |
| 307_L | 310_D | 1.099 | 0.96 | |
| 309_E | 322_R | 1.096 | 0.96 | |
| 345_L | 392_V | 1.086 | 0.96 | |
| 138_V | 158_T | 1.081 | 0.95 | |
| 184_T | 187_H | 1.076 | 0.95 | |
| 143_N | 147_L | 1.062 | 0.95 | |
| 114_V | 137_V | 1.062 | 0.95 | |
| 113_I | 140_L | 1.062 | 0.95 | |
| 153_L | 182_A | 1.061 | 0.95 | |
| 284_A | 288_W | 1.061 | 0.95 | |
| 308_A | 376_F | 1.058 | 0.95 | |
| 33_E | 44_S | 1.056 | 0.95 | |
| 94_I | 194_M | 1.056 | 0.95 | |
| 67_A | 287_E | 1.046 | 0.94 | |
| 185_F | 191_M | 1.044 | 0.94 | |
| 74_Q | 290_A | 1.038 | 0.94 | |
| 99_Q | 133_T | 1.036 | 0.94 | |
| 215_F | 238_L | 1.032 | 0.94 | |
| 341_M | 395_A | 1.03 | 0.94 | |
| 308_A | 389_V | 1.027 | 0.94 | |
| 34_A | 37_E | 1.027 | 0.94 | |
| 283_S | 287_E | 1.025 | 0.93 | |
| 303_S | 307_L | 1.019 | 0.93 | |
| 71_K | 286_L | 1.019 | 0.93 | |
| 41_Q | 44_S | 1.018 | 0.93 | |
| 84_I | 233_Y | 1.018 | 0.93 | |
| 341_M | 372_L | 1.017 | 0.93 | |
| 308_A | 385_V | 1.016 | 0.93 | |
| 391_A | 394_R | 1.014 | 0.93 | |
| 308_A | 388_L | 1.013 | 0.93 | |
| 74_Q | 287_E | 1.008 | 0.93 | |
| 298_E | 302_R | 1.005 | 0.93 | |
| 384_D | 387_A | 1.004 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4lw2A | 3 | 1 | 100 | 0.21 | Contact Map | 0.756 |
| 1kmjA | 1 | 0.9925 | 100 | 0.214 | Contact Map | 0.716 |
| 1t3iA | 2 | 0.9975 | 100 | 0.238 | Contact Map | 0.729 |
| 1eluA | 2 | 0.9401 | 100 | 0.275 | Contact Map | 0.71 |
| 3caiA | 2 | 0.9426 | 100 | 0.279 | Contact Map | 0.73 |
| 3e9kA | 1 | 0.9551 | 100 | 0.286 | Contact Map | 0.593 |
| 4hvkA | 1 | 0.9002 | 100 | 0.29 | Contact Map | 0.658 |
| 1eg5A | 2 | 0.9027 | 100 | 0.306 | Contact Map | 0.711 |
| 3a9zA | 2 | 0.9426 | 100 | 0.306 | Contact Map | 0.744 |
| 3vaxA | 2 | 0.9202 | 100 | 0.307 | Contact Map | 0.671 |
Sequence Conservation (Image Generated using WebLogo v3)