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OPENSEQ.org
MALY - Protein MalY
UniProt: P23256 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10564
Length: 390 (360)
Sequences: 19637
Seq/Len: 54.55
MALY
Paralog alert: 0.93 [within 20: 0.26] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_N 55_M 2.951 1.00
155_E 193_R 2.906 1.00
93_G 99_M 2.752 1.00
296_K 300_T 2.738 1.00
181_C 185_E 2.734 1.00
113_G 134_T 2.694 1.00
297_D 372_R 2.645 1.00
78_S 84_A 2.629 1.00
44_P 48_E 2.506 1.00
314_N 327_D 2.486 1.00
72_A 282_Q 2.416 1.00
108_S 133_R 2.359 1.00
112_E 164_K 2.317 1.00
341_A 345_Q 2.228 1.00
247_I 253_R 2.219 1.00
377_K 381_G 2.219 1.00
68_E 278_I 2.178 1.00
301_Y 376_E 2.175 1.00
346_E 384_N 2.148 1.00
48_E 52_Q 2.135 1.00
180_T 183_E 2.126 1.00
242_G 277_H 2.087 1.00
334_D 337_A 2.05 1.00
377_K 380_A 2.039 1.00
185_E 189_D 2.015 1.00
101_S 105_R 1.983 1.00
71_A 75_H 1.937 1.00
71_A 87_S 1.9 1.00
303_A 307_N 1.859 1.00
305_K 380_A 1.835 1.00
191_C 198_V 1.827 1.00
113_G 136_M 1.824 1.00
152_G 186_I 1.81 1.00
300_T 304_D 1.798 1.00
303_A 317_I 1.776 1.00
305_K 308_A 1.764 1.00
199_I 228_L 1.761 1.00
304_D 308_A 1.76 1.00
67_D 71_A 1.756 1.00
165_I 199_I 1.74 1.00
128_I 133_R 1.732 1.00
182_D 185_E 1.718 1.00
305_K 379_V 1.714 1.00
118_T 137_P 1.71 1.00
72_A 75_H 1.701 1.00
155_E 186_I 1.697 1.00
150_D 153_K 1.687 1.00
33_F 378_G 1.681 1.00
75_H 282_Q 1.679 1.00
203_I 230_S 1.672 1.00
186_I 189_D 1.661 1.00
96_V 228_L 1.653 1.00
103_L 199_I 1.652 1.00
195_G 224_D 1.636 1.00
301_Y 372_R 1.629 1.00
141_E 183_E 1.622 1.00
74_A 87_S 1.621 1.00
153_K 157_V 1.615 1.00
148_F 183_E 1.606 1.00
79_T 285_A 1.605 1.00
301_Y 305_K 1.586 1.00
103_L 226_A 1.585 1.00
341_A 385_A 1.568 1.00
307_N 315_W 1.549 1.00
47_I 51_N 1.546 1.00
245_G 256_Y 1.532 1.00
114_V 128_I 1.531 1.00
113_G 159_A 1.525 1.00
153_K 156_A 1.521 1.00
289_D 293_I 1.517 1.00
350_I 364_V 1.508 1.00
125_Y 129_E 1.507 1.00
192_E 223_G 1.506 1.00
340_K 344_E 1.483 1.00
52_Q 279_A 1.482 1.00
73_I 244_Y 1.471 1.00
337_A 341_A 1.468 1.00
113_G 163_C 1.467 1.00
346_E 381_G 1.452 1.00
371_P 374_K 1.444 1.00
191_C 196_V 1.438 1.00
151_M 190_L 1.437 1.00
88_Q 250_S 1.43 1.00
270_S 273_A 1.428 1.00
85_I 246_I 1.413 1.00
158_L 190_L 1.412 1.00
68_E 282_Q 1.412 1.00
380_A 384_N 1.395 0.99
77_F 246_I 1.394 0.99
305_K 383_I 1.378 0.99
189_D 193_R 1.376 0.99
73_I 92_Y 1.37 0.99
49_A 279_A 1.367 0.99
104_I 128_I 1.364 0.99
113_G 162_E 1.361 0.99
302_I 324_A 1.346 0.99
181_C 215_I 1.343 0.99
48_E 51_N 1.342 0.99
189_D 192_E 1.34 0.99
335_D 354_Y 1.338 0.99
155_E 194_H 1.334 0.99
75_H 79_T 1.331 0.99
289_D 292_R 1.33 0.99
118_T 139_A 1.327 0.99
305_K 376_E 1.325 0.99
303_A 324_A 1.325 0.99
44_P 47_I 1.32 0.99
74_A 90_V 1.319 0.99
337_A 340_K 1.305 0.99
72_A 278_I 1.297 0.99
104_I 167_L 1.294 0.99
183_E 186_I 1.291 0.99
226_A 245_G 1.278 0.99
303_A 315_W 1.262 0.99
98_Y 260_L 1.258 0.99
151_M 186_I 1.258 0.99
307_N 317_I 1.257 0.99
339_Q 350_I 1.257 0.99
334_D 361_R 1.242 0.98
139_A 153_K 1.241 0.98
70_L 74_A 1.237 0.98
125_Y 137_P 1.237 0.98
66_N 275_T 1.235 0.98
190_L 194_H 1.222 0.98
116_I 135_V 1.216 0.98
248_E 251_S 1.209 0.98
325_W 353_G 1.208 0.98
299_L 303_A 1.208 0.98
294_Y 372_R 1.206 0.98
342_L 382_L 1.206 0.98
182_D 186_I 1.206 0.98
91_V 253_R 1.204 0.98
104_I 108_S 1.204 0.98
293_I 296_K 1.196 0.98
67_D 87_S 1.196 0.98
52_Q 56_H 1.19 0.98
231_G 277_H 1.186 0.98
342_L 350_I 1.186 0.98
28_A 347_K 1.185 0.98
181_C 220_V 1.181 0.98
89_T 250_S 1.18 0.98
279_A 282_Q 1.176 0.98
155_E 190_L 1.176 0.98
105_R 131_N 1.174 0.98
226_A 247_I 1.173 0.98
376_E 380_A 1.173 0.98
108_S 114_V 1.172 0.98
302_I 379_V 1.171 0.98
255_A 258_S 1.165 0.97
293_I 297_D 1.165 0.97
47_I 55_M 1.158 0.97
190_L 196_V 1.153 0.97
114_V 165_I 1.151 0.97
141_E 150_D 1.149 0.97
308_A 383_I 1.148 0.97
254_D 258_S 1.146 0.97
86_D 250_S 1.146 0.97
77_F 244_Y 1.142 0.97
156_A 160_K 1.141 0.97
115_V 163_C 1.137 0.97
64_W 257_L 1.134 0.97
107_W 197_R 1.133 0.97
73_I 90_V 1.133 0.97
383_I 387_R 1.124 0.97
50_L 276_A 1.117 0.96
229_T 244_Y 1.115 0.96
294_Y 297_D 1.112 0.96
68_E 275_T 1.111 0.96
69_F 92_Y 1.109 0.96
181_C 219_N 1.108 0.96
304_D 307_N 1.106 0.96
155_E 159_A 1.105 0.96
64_W 70_L 1.103 0.96
94_P 98_Y 1.102 0.96
166_M 196_V 1.101 0.96
372_R 376_E 1.098 0.96
278_I 282_Q 1.093 0.96
185_E 220_V 1.088 0.96
158_L 196_V 1.086 0.96
152_G 156_A 1.082 0.96
327_D 363_F 1.076 0.95
374_K 377_K 1.072 0.95
197_R 226_A 1.066 0.95
210_G 319_Q 1.062 0.95
304_D 376_E 1.061 0.95
326_L 366_L 1.059 0.95
99_M 245_G 1.058 0.95
106_Q 259_A 1.049 0.94
298_N 301_Y 1.042 0.94
299_L 368_A 1.038 0.94
188_A 225_W 1.036 0.94
286_P 290_A 1.032 0.94
279_A 283_Q 1.032 0.94
188_A 198_V 1.031 0.94
50_L 54_L 1.027 0.94
86_D 89_T 1.026 0.94
300_T 317_I 1.023 0.93
38_M 295_L 1.019 0.93
198_V 217_W 1.019 0.93
305_K 310_F 1.019 0.93
115_V 138_V 1.016 0.93
110_T 132_Q 1.014 0.93
141_E 144_A 1.013 0.93
90_V 246_I 1.008 0.93
106_Q 256_Y 1.008 0.93
348_V 382_L 1.007 0.93
128_I 135_V 1.004 0.93
68_E 71_A 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1d2fA20.99741000.264Contact Map0.696
1c7nA80.99491000.27Contact Map0.747
4dq6A20.98211000.287Contact Map0.77
3kaxA10.97441000.289Contact Map0.741
3dzzA20.97951000.292Contact Map0.725
3b1dA40.97951000.298Contact Map0.747
3dydA20.97691000.303Contact Map0.791
2x5dA40.98211000.303Contact Map0.765
1j32A20.97441000.306Contact Map0.792
1vp4A20.96921000.307Contact Map0.79
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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