| UniProt: | P00509 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10096 | ||
| Length: | 396 (383) | ||
| Sequences: | 19018 | ||
| Seq/Len: | 49.66 |
| AAT
Paralog alert: 0.93 [within 20: 0.25] - ratio of genomes with paralogs Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 163_I | 203_E | 3.131 | 1.00 | |
| 319_Q | 323_Q | 2.994 | 1.00 | |
| 122_R | 143_E | 2.961 | 1.00 | |
| 54_Q | 58_E | 2.954 | 1.00 | |
| 191_L | 195_Q | 2.92 | 1.00 | |
| 320_R | 382_P | 2.839 | 1.00 | |
| 100_T | 106_A | 2.813 | 1.00 | |
| 365_F | 394_A | 2.77 | 1.00 | |
| 83_F | 89_L | 2.718 | 1.00 | |
| 324_L | 386_A | 2.671 | 1.00 | |
| 47_T | 51_K | 2.595 | 1.00 | |
| 77_C | 299_S | 2.554 | 1.00 | |
| 339_S | 352_G | 2.524 | 1.00 | |
| 360_R | 364_E | 2.523 | 1.00 | |
| 121_K | 173_D | 2.521 | 1.00 | |
| 117_N | 142_L | 2.485 | 1.00 | |
| 387_P | 391_A | 2.453 | 1.00 | |
| 73_E | 295_A | 2.263 | 1.00 | |
| 195_Q | 199_Q | 2.2 | 1.00 | |
| 190_T | 193_Q | 2.188 | 1.00 | |
| 255_V | 294_V | 2.155 | 1.00 | |
| 51_K | 55_Y | 2.128 | 1.00 | |
| 76_R | 80_E | 2.084 | 1.00 | |
| 387_P | 390_E | 2.074 | 1.00 | |
| 328_T | 389_C | 2.062 | 1.00 | |
| 76_R | 92_D | 2.02 | 1.00 | |
| 260_L | 272_F | 1.996 | 1.00 | |
| 108_R | 112_D | 1.979 | 1.00 | |
| 381_T | 384_N | 1.976 | 1.00 | |
| 160_D | 196_T | 1.934 | 1.00 | |
| 328_T | 331_E | 1.929 | 1.00 | |
| 323_Q | 327_N | 1.924 | 1.00 | |
| 122_R | 145_R | 1.921 | 1.00 | |
| 201_S | 208_P | 1.916 | 1.00 | |
| 192_E | 195_Q | 1.913 | 1.00 | |
| 327_N | 331_E | 1.912 | 1.00 | |
| 174_V | 209_L | 1.911 | 1.00 | |
| 326_V | 330_Q | 1.902 | 1.00 | |
| 72_P | 76_R | 1.856 | 1.00 | |
| 137_F | 142_L | 1.853 | 1.00 | |
| 326_V | 342_I | 1.833 | 1.00 | |
| 209_L | 241_A | 1.828 | 1.00 | |
| 163_I | 196_T | 1.815 | 1.00 | |
| 158_D | 161_A | 1.802 | 1.00 | |
| 127_N | 146_E | 1.795 | 1.00 | |
| 77_C | 80_E | 1.791 | 1.00 | |
| 213_A | 243_S | 1.779 | 1.00 | |
| 31_L | 388_L | 1.771 | 1.00 | |
| 103_G | 241_A | 1.77 | 1.00 | |
| 156_T | 193_Q | 1.759 | 1.00 | |
| 324_L | 382_P | 1.746 | 1.00 | |
| 80_E | 299_S | 1.735 | 1.00 | |
| 196_T | 199_Q | 1.73 | 1.00 | |
| 110_A | 209_L | 1.726 | 1.00 | |
| 205_G | 237_E | 1.724 | 1.00 | |
| 161_A | 165_S | 1.678 | 1.00 | |
| 79_Q | 92_D | 1.673 | 1.00 | |
| 330_Q | 340_F | 1.667 | 1.00 | |
| 324_L | 328_T | 1.656 | 1.00 | |
| 55_Y | 296_T | 1.635 | 1.00 | |
| 110_A | 239_I | 1.633 | 1.00 | |
| 161_A | 164_N | 1.628 | 1.00 | |
| 78_T | 257_A | 1.608 | 1.00 | |
| 312_T | 316_Q | 1.603 | 1.00 | |
| 50_K | 54_Q | 1.577 | 1.00 | |
| 93_K | 265_S | 1.567 | 1.00 | |
| 123_V | 137_F | 1.56 | 1.00 | |
| 199_Q | 203_E | 1.552 | 1.00 | |
| 122_R | 172_G | 1.544 | 1.00 | |
| 150_Y | 193_Q | 1.542 | 1.00 | |
| 134_K | 138_N | 1.539 | 1.00 | |
| 73_E | 299_S | 1.531 | 1.00 | |
| 258_C | 275_M | 1.525 | 1.00 | |
| 287_P | 290_G | 1.515 | 1.00 | |
| 84_G | 308_E | 1.508 | 1.00 | |
| 325_F | 349_S | 1.505 | 1.00 | |
| 122_R | 171_A | 1.491 | 1.00 | |
| 51_K | 54_Q | 1.491 | 1.00 | |
| 78_T | 99_Q | 1.485 | 1.00 | |
| 201_S | 206_W | 1.483 | 1.00 | |
| 77_C | 295_A | 1.475 | 1.00 | |
| 199_Q | 202_V | 1.474 | 1.00 | |
| 111_A | 137_F | 1.467 | 1.00 | |
| 359_L | 363_E | 1.458 | 1.00 | |
| 52_A | 296_T | 1.443 | 1.00 | |
| 111_A | 176_L | 1.441 | 1.00 | |
| 90_I | 259_T | 1.44 | 1.00 | |
| 326_V | 349_S | 1.437 | 1.00 | |
| 122_R | 167_N | 1.436 | 1.00 | |
| 163_I | 204_K | 1.43 | 1.00 | |
| 166_L | 200_L | 1.43 | 1.00 | |
| 390_E | 394_A | 1.429 | 1.00 | |
| 312_T | 315_R | 1.428 | 1.00 | |
| 71_I | 292_S | 1.425 | 1.00 | |
| 328_T | 390_E | 1.425 | 1.00 | |
| 159_F | 200_L | 1.418 | 1.00 | |
| 177_F | 197_L | 1.417 | 1.00 | |
| 328_T | 393_V | 1.411 | 1.00 | |
| 111_A | 117_N | 1.388 | 0.99 | |
| 163_I | 167_N | 1.378 | 0.99 | |
| 326_V | 340_F | 1.371 | 0.99 | |
| 80_E | 84_G | 1.371 | 0.99 | |
| 328_T | 386_A | 1.368 | 0.99 | |
| 127_N | 148_A | 1.367 | 0.99 | |
| 382_P | 386_A | 1.362 | 0.99 | |
| 328_T | 332_K | 1.34 | 0.99 | |
| 75_G | 79_Q | 1.332 | 0.99 | |
| 365_F | 391_A | 1.33 | 0.99 | |
| 82_L | 259_T | 1.316 | 0.99 | |
| 79_Q | 95_A | 1.313 | 0.99 | |
| 123_V | 174_V | 1.308 | 0.99 | |
| 191_L | 226_E | 1.307 | 0.99 | |
| 193_Q | 196_T | 1.301 | 0.99 | |
| 175_V | 206_W | 1.301 | 0.99 | |
| 239_I | 258_C | 1.3 | 0.99 | |
| 330_Q | 342_I | 1.3 | 0.99 | |
| 148_A | 161_A | 1.294 | 0.99 | |
| 244_Y | 294_V | 1.282 | 0.99 | |
| 47_T | 50_K | 1.281 | 0.99 | |
| 69_D | 276_K | 1.276 | 0.99 | |
| 200_L | 204_K | 1.275 | 0.99 | |
| 386_A | 390_E | 1.274 | 0.99 | |
| 114_L | 207_L | 1.268 | 0.99 | |
| 239_I | 260_L | 1.266 | 0.99 | |
| 195_Q | 234_M | 1.265 | 0.99 | |
| 150_Y | 153_E | 1.262 | 0.99 | |
| 316_Q | 319_Q | 1.261 | 0.99 | |
| 69_D | 75_G | 1.255 | 0.99 | |
| 125_V | 144_V | 1.251 | 0.99 | |
| 105_G | 279_I | 1.251 | 0.99 | |
| 159_F | 196_T | 1.248 | 0.99 | |
| 78_T | 95_A | 1.245 | 0.98 | |
| 274_Q | 277_A | 1.237 | 0.98 | |
| 117_N | 123_V | 1.237 | 0.98 | |
| 72_P | 92_D | 1.236 | 0.98 | |
| 112_D | 140_A | 1.23 | 0.98 | |
| 200_L | 206_W | 1.226 | 0.98 | |
| 134_K | 146_E | 1.224 | 0.98 | |
| 358_V | 369_A | 1.223 | 0.98 | |
| 53_E | 293_V | 1.222 | 0.98 | |
| 164_N | 168_E | 1.22 | 0.98 | |
| 325_F | 389_C | 1.22 | 0.98 | |
| 322_R | 326_V | 1.21 | 0.98 | |
| 98_A | 272_F | 1.208 | 0.98 | |
| 331_E | 393_V | 1.207 | 0.98 | |
| 82_L | 257_A | 1.198 | 0.98 | |
| 192_E | 196_T | 1.194 | 0.98 | |
| 91_N | 265_S | 1.189 | 0.98 | |
| 91_N | 94_R | 1.189 | 0.98 | |
| 26_P | 366_G | 1.182 | 0.98 | |
| 160_D | 164_N | 1.177 | 0.98 | |
| 242_S | 257_A | 1.175 | 0.98 | |
| 53_E | 57_L | 1.174 | 0.98 | |
| 317_R | 320_R | 1.171 | 0.98 | |
| 296_T | 299_S | 1.171 | 0.98 | |
| 327_N | 330_Q | 1.168 | 0.97 | |
| 50_K | 58_E | 1.166 | 0.97 | |
| 301_D | 309_Q | 1.165 | 0.97 | |
| 220_G | 344_Q | 1.161 | 0.97 | |
| 295_A | 299_S | 1.161 | 0.97 | |
| 323_Q | 342_I | 1.154 | 0.97 | |
| 114_L | 174_V | 1.152 | 0.97 | |
| 74_F | 99_Q | 1.151 | 0.97 | |
| 163_I | 200_L | 1.148 | 0.97 | |
| 55_Y | 59_N | 1.147 | 0.97 | |
| 191_L | 231_F | 1.146 | 0.97 | |
| 73_E | 292_S | 1.145 | 0.97 | |
| 273_S | 277_A | 1.144 | 0.97 | |
| 94_R | 265_S | 1.135 | 0.97 | |
| 150_Y | 158_D | 1.129 | 0.97 | |
| 375_V | 388_L | 1.128 | 0.97 | |
| 198_A | 208_P | 1.128 | 0.97 | |
| 113_F | 278_A | 1.121 | 0.97 | |
| 119_S | 141_G | 1.116 | 0.96 | |
| 101_P | 105_G | 1.115 | 0.96 | |
| 124_W | 172_G | 1.107 | 0.96 | |
| 316_Q | 320_R | 1.099 | 0.96 | |
| 207_L | 239_I | 1.084 | 0.96 | |
| 325_F | 328_T | 1.083 | 0.96 | |
| 350_F | 372_S | 1.083 | 0.96 | |
| 279_I | 283_Y | 1.082 | 0.96 | |
| 79_Q | 91_N | 1.078 | 0.95 | |
| 202_V | 235_H | 1.076 | 0.95 | |
| 351_S | 375_V | 1.075 | 0.95 | |
| 332_K | 393_V | 1.069 | 0.95 | |
| 322_R | 377_V | 1.068 | 0.95 | |
| 101_P | 287_P | 1.068 | 0.95 | |
| 325_F | 385_M | 1.067 | 0.95 | |
| 317_R | 382_P | 1.067 | 0.95 | |
| 113_F | 275_M | 1.062 | 0.95 | |
| 166_L | 206_W | 1.058 | 0.95 | |
| 309_Q | 313_D | 1.057 | 0.95 | |
| 137_F | 144_V | 1.055 | 0.95 | |
| 191_L | 230_A | 1.052 | 0.95 | |
| 106_A | 241_A | 1.042 | 0.94 | |
| 361_L | 392_I | 1.04 | 0.94 | |
| 356_E | 360_R | 1.038 | 0.94 | |
| 19_L | 363_E | 1.036 | 0.94 | |
| 124_W | 147_Y | 1.035 | 0.94 | |
| 118_T | 121_K | 1.035 | 0.94 | |
| 198_A | 238_L | 1.03 | 0.94 | |
| 73_E | 76_R | 1.028 | 0.94 | |
| 103_G | 243_S | 1.026 | 0.94 | |
| 255_V | 286_P | 1.026 | 0.94 | |
| 71_I | 295_A | 1.014 | 0.93 | |
| 109_V | 279_I | 1.01 | 0.93 | |
| 338_F | 351_S | 1.01 | 0.93 | |
| 296_T | 300_N | 1.007 | 0.93 | |
| 265_S | 270_R | 1.006 | 0.93 | |
| 129_S | 178_H | 1.005 | 0.93 | |
| 356_E | 359_L | 1 | 0.92 | |
| 317_R | 321_M | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4f4eA | 2 | 0.9924 | 100 | 0.252 | Contact Map | 0.548 |
| 7aatA | 2 | 0.9924 | 100 | 0.264 | Contact Map | 0.574 |
| 4h51A | 2 | 0.9672 | 100 | 0.267 | Contact Map | 0.566 |
| 2q7wA | 1 | 0.9924 | 100 | 0.271 | Contact Map | 0.56 |
| 4eu1A | 2 | 0.9697 | 100 | 0.271 | Contact Map | 0.504 |
| 1ajsA | 1 | 0.9874 | 100 | 0.278 | Contact Map | 0.562 |
| 3fslA | 6 | 0.9924 | 100 | 0.281 | Contact Map | 0.589 |
| 1yaaA | 4 | 0.9823 | 100 | 0.281 | Contact Map | 0.588 |
| 2ay1A | 2 | 0.9848 | 100 | 0.283 | Contact Map | 0.569 |
| 3k7yA | 1 | 0.9773 | 100 | 0.288 | Contact Map | 0.522 |
Sequence Conservation (Image Generated using WebLogo v3)