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OPENSEQ.org
ARNB - UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
UniProt: P77690 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14089
Length: 379 (357)
Sequences: 32270
Seq/Len: 90.39
ARNB
Paralog alert: 0.92 [within 20: 0.48] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
266_Q 367_D 3.651 1.00
316_R 375_Q 3.353 1.00
21_K 25_E 3.278 1.00
115_E 146_R 3.27 1.00
270_A 370_I 3.186 1.00
262_E 363_T 2.913 1.00
41_A 246_A 2.856 1.00
14_V 18_A 2.783 1.00
266_Q 363_T 2.782 1.00
368_H 372_A 2.754 1.00
75_E 96_T 2.683 1.00
136_D 139_A 2.65 1.00
75_E 98_V 2.452 1.00
261_R 265_Q 2.448 1.00
54_V 60_G 2.422 1.00
74_D 123_K 2.345 1.00
18_A 22_E 2.343 1.00
362_T 365_D 2.341 1.00
113_A 116_S 2.313 1.00
75_E 119_T 2.305 1.00
111_P 143_I 2.212 1.00
70_I 95_A 2.138 1.00
266_Q 270_A 2.106 1.00
113_A 117_A 2.104 1.00
243_A 246_A 2.096 1.00
278_P 296_R 2.063 1.00
368_H 371_T 2.044 1.00
316_R 372_A 2.043 1.00
265_Q 269_Q 2.029 1.00
270_A 273_A 2.02 1.00
305_S 308_A 2.012 1.00
17_L 21_K 1.985 1.00
75_E 122_T 1.983 1.00
141_R 151_V 1.945 1.00
40_Q 44_Q 1.923 1.00
75_E 121_R 1.911 1.00
270_A 367_D 1.898 1.00
139_A 142_A 1.853 1.00
50_H 197_E 1.851 1.00
80_S 101_D 1.844 1.00
142_A 146_R 1.84 1.00
110_T 113_A 1.836 1.00
312_A 315_E 1.836 1.00
115_E 147_Y 1.832 1.00
138_D 142_A 1.814 1.00
124_A 152_I 1.8 1.00
101_D 113_A 1.791 1.00
270_A 374_Q 1.774 1.00
141_R 145_E 1.728 1.00
49_Q 197_E 1.704 1.00
18_A 21_K 1.704 1.00
37_A 242_N 1.68 1.00
17_L 25_E 1.677 1.00
312_A 376_L 1.668 1.00
274_L 374_Q 1.662 1.00
155_A 174_A 1.66 1.00
115_E 143_I 1.642 1.00
22_E 26_S 1.636 1.00
273_A 374_Q 1.627 1.00
144_G 149_I 1.626 1.00
193_V 200_A 1.626 1.00
259_R 262_E 1.622 1.00
62_H 66_M 1.615 1.00
41_A 242_N 1.614 1.00
144_G 151_V 1.599 1.00
258_T 262_E 1.57 1.00
76_V 90_I 1.563 1.00
100_V 117_A 1.561 1.00
57_A 175_I 1.552 1.00
125_I 149_I 1.546 1.00
355_L 369_V 1.53 1.00
254_E 258_T 1.529 1.00
111_P 139_A 1.525 1.00
178_F 241_I 1.525 1.00
259_R 263_I 1.516 1.00
36_Q 40_Q 1.516 1.00
311_E 315_E 1.509 1.00
118_I 143_I 1.505 1.00
308_A 312_A 1.498 1.00
270_A 371_T 1.489 1.00
103_D 106_T 1.487 1.00
269_Q 273_A 1.483 1.00
145_E 173_T 1.473 1.00
112_E 139_A 1.464 1.00
143_I 147_Y 1.453 1.00
55_S 59_A 1.451 1.00
363_T 367_D 1.45 1.00
90_I 95_A 1.444 1.00
266_Q 366_A 1.44 1.00
176_F 190_G 1.437 1.00
167_H 170_A 1.435 1.00
115_E 119_T 1.431 1.00
125_I 144_G 1.429 1.00
371_T 375_Q 1.428 1.00
259_R 363_T 1.428 1.00
127_P 140_I 1.427 1.00
268_Q 272_A 1.424 1.00
115_E 139_A 1.42 1.00
268_Q 293_F 1.41 1.00
41_A 44_Q 1.409 1.00
80_S 99_M 1.408 1.00
65_L 126_I 1.391 0.99
112_E 116_S 1.381 0.99
77_I 117_A 1.38 0.99
188_E 241_I 1.379 0.99
77_I 122_T 1.375 0.99
112_E 115_E 1.36 0.99
103_D 110_T 1.357 0.99
296_R 351_R 1.354 0.99
312_A 316_R 1.35 0.99
71_G 74_D 1.347 0.99
129_H 158_A 1.343 0.99
15_E 243_A 1.336 0.99
367_D 371_T 1.335 0.99
320_T 353_C 1.333 0.99
98_V 117_A 1.316 0.99
64_T 152_I 1.304 0.99
65_L 90_I 1.275 0.99
255_H 258_T 1.272 0.99
74_D 121_R 1.263 0.99
60_G 175_I 1.262 0.99
61_M 85_S 1.257 0.99
272_A 279_L 1.256 0.99
308_A 311_E 1.244 0.98
119_T 122_T 1.244 0.98
19_A 22_E 1.237 0.98
263_I 363_T 1.236 0.98
20_V 240_D 1.23 0.98
313_L 320_T 1.228 0.98
43_C 51_A 1.21 0.98
15_E 247_L 1.207 0.98
264_A 268_Q 1.206 0.98
138_D 170_A 1.2 0.98
90_I 97_P 1.199 0.98
17_L 24_L 1.191 0.98
318_I 372_A 1.188 0.98
42_F 53_A 1.187 0.98
258_T 261_R 1.184 0.98
42_F 190_G 1.177 0.98
310_M 320_T 1.176 0.98
268_Q 281_L 1.176 0.98
118_I 149_I 1.174 0.98
68_L 150_A 1.162 0.97
197_E 201_R 1.16 0.97
37_A 246_A 1.156 0.97
44_Q 246_A 1.152 0.97
269_Q 272_A 1.147 0.97
313_L 373_L 1.143 0.97
364_A 367_D 1.141 0.97
37_A 41_A 1.138 0.97
152_I 175_I 1.137 0.97
19_A 243_A 1.137 0.97
14_V 17_L 1.137 0.97
295_I 355_L 1.135 0.97
87_L 91_S 1.131 0.97
18_A 25_E 1.12 0.96
318_I 369_V 1.117 0.96
278_P 298_D 1.106 0.96
66_M 93_L 1.097 0.96
52_I 200_A 1.092 0.96
142_A 145_E 1.091 0.96
156_A 177_S 1.085 0.96
254_E 257_N 1.08 0.95
114_I 140_I 1.08 0.95
72_K 94_G 1.08 0.95
267_Y 270_A 1.078 0.95
61_M 152_I 1.073 0.95
248_T 251_V 1.071 0.95
270_A 274_L 1.07 0.95
309_L 376_L 1.052 0.95
14_V 25_E 1.051 0.94
41_A 247_L 1.047 0.94
143_I 149_I 1.044 0.94
118_I 122_T 1.042 0.94
15_E 18_A 1.04 0.94
266_Q 269_Q 1.039 0.94
22_E 25_E 1.038 0.94
87_L 99_M 1.036 0.94
280_S 296_R 1.035 0.94
41_A 249_Q 1.033 0.94
309_L 353_C 1.028 0.94
51_A 192_I 1.021 0.93
173_T 196_N 1.018 0.93
70_I 76_V 1.018 0.93
39_E 43_C 1.017 0.93
49_Q 195_D 1.016 0.93
372_A 375_Q 1.016 0.93
144_G 147_Y 1.015 0.93
77_I 100_V 1.015 0.93
267_Y 366_A 1.014 0.93
305_S 350_E 1.013 0.93
22_E 34_K 1.013 0.93
255_H 259_R 1.009 0.93
268_Q 279_L 1.005 0.93
20_V 24_L 1.005 0.93
267_Y 355_L 1.004 0.93
103_D 108_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4lc3A20.97891000.289Contact Map0.68
2fnuA20.9711000.293Contact Map0.692
1mdoA10.99471000.297Contact Map0.589
3frkA20.94991000.304Contact Map0.684
1o69A20.95511000.321Contact Map0.645
3dr4A40.96041000.334Contact Map0.692
3nytA10.94461000.337Contact Map0.639
2c81A10.99471000.339Contact Map0.661
2ogaA40.95251000.343Contact Map0.676
2po3A20.95781000.345Contact Map0.616
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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