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OPENSEQ.org
SUFS - Cysteine desulfurase
UniProt: P77444 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13962
Length: 406 (377)
Sequences: 31443
Seq/Len: 83.40
SUFS
Paralog alert: 0.93 [within 20: 0.47] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
312_Y 392_D 3.959 1.00
44_A 48_R 3.539 1.00
316_Q 395_V 3.41 1.00
354_Y 400_R 3.399 1.00
158_P 192_Q 3.373 1.00
312_Y 388_H 3.04 1.00
75_R 292_E 3.011 1.00
308_N 388_H 2.979 1.00
37_S 41_D 2.825 1.00
393_R 397_G 2.742 1.00
182_P 185_E 2.654 1.00
115_N 140_E 2.642 1.00
115_N 142_R 2.47 1.00
41_D 45_E 2.436 1.00
350_F 353_N 2.424 1.00
115_N 162_D 2.414 1.00
307_Q 311_H 2.411 1.00
387_T 390_E 2.394 1.00
289_A 292_E 2.349 1.00
324_T 338_N 2.334 1.00
156_T 159_T 2.304 1.00
316_Q 319_S 2.264 1.00
312_Y 316_Q 2.263 1.00
154_L 189_L 2.25 1.00
114_D 166_R 2.236 1.00
91_V 97_G 2.231 1.00
156_T 160_L 2.216 1.00
238_V 243_L 2.188 1.00
393_R 396_T 2.114 1.00
75_R 288_G 2.104 1.00
280_N 283_G 2.07 1.00
311_H 315_S 2.068 1.00
115_N 165_T 2.041 1.00
158_P 193_H 2.031 1.00
343_H 346_D 2.017 1.00
40_I 44_A 2.014 1.00
354_Y 397_G 2 1.00
187_I 197_V 1.998 1.00
316_Q 392_D 1.987 1.00
187_I 191_H 1.984 1.00
120_Q 145_P 1.971 1.00
110_V 139_A 1.931 1.00
74_K 78_L 1.928 1.00
316_Q 399_Q 1.927 1.00
184_A 188_T 1.91 1.00
188_T 192_Q 1.872 1.00
167_L 198_L 1.836 1.00
153_Q 156_T 1.834 1.00
185_E 188_T 1.833 1.00
222_F 235_I 1.832 1.00
145_P 156_T 1.809 1.00
41_D 44_A 1.798 1.00
27_L 394_L 1.778 1.00
320_V 399_Q 1.755 1.00
115_N 164_K 1.747 1.00
101_V 219_F 1.746 1.00
350_F 401_I 1.739 1.00
158_P 189_L 1.737 1.00
201_G 220_Y 1.721 1.00
305_Y 308_N 1.704 1.00
45_E 49_H 1.703 1.00
380_A 394_L 1.69 1.00
319_S 399_Q 1.688 1.00
154_L 185_E 1.673 1.00
71_N 288_G 1.67 1.00
304_E 308_N 1.658 1.00
168_L 195_A 1.653 1.00
190_A 195_A 1.65 1.00
144_I 160_L 1.642 1.00
190_A 197_V 1.635 1.00
76_A 235_I 1.628 1.00
388_H 392_D 1.611 1.00
224_G 287_L 1.609 1.00
315_S 319_S 1.579 1.00
314_L 335_I 1.577 1.00
305_Y 309_L 1.572 1.00
70_E 74_K 1.556 1.00
314_L 318_E 1.554 1.00
40_I 48_R 1.536 1.00
346_D 350_F 1.536 1.00
191_H 216_D 1.534 1.00
300_N 304_E 1.532 1.00
38_Q 289_A 1.53 1.00
75_R 295_S 1.528 1.00
155_E 159_T 1.527 1.00
172_H 204_A 1.522 1.00
189_L 193_H 1.52 1.00
316_Q 396_T 1.517 1.00
168_L 190_A 1.515 1.00
42_A 289_A 1.506 1.00
161_F 189_L 1.485 1.00
92_R 96_E 1.476 1.00
43_E 286_G 1.474 1.00
155_E 185_E 1.469 1.00
312_Y 391_V 1.461 1.00
117_I 160_L 1.453 1.00
142_R 160_L 1.448 1.00
233_I 287_L 1.447 1.00
155_E 158_P 1.443 1.00
86_E 240_E 1.443 1.00
120_Q 143_V 1.442 1.00
396_T 400_R 1.442 1.00
83_R 86_E 1.438 1.00
38_Q 293_Y 1.437 1.00
158_P 162_D 1.435 1.00
114_D 164_K 1.429 1.00
94_T 221_V 1.428 1.00
42_A 45_E 1.428 1.00
99_N 103_N 1.422 1.00
338_N 376_A 1.396 0.99
97_G 221_V 1.39 0.99
87_E 240_E 1.39 0.99
158_P 185_E 1.389 0.99
191_H 218_D 1.386 0.99
198_L 221_V 1.351 0.99
184_A 214_A 1.341 0.99
98_I 125_A 1.34 0.99
75_R 78_L 1.337 0.99
392_D 396_T 1.334 0.99
305_Y 388_H 1.307 0.99
102_A 169_A 1.303 0.99
111_R 114_D 1.303 0.99
101_V 198_L 1.301 0.99
147_N 153_Q 1.293 0.99
236_L 246_M 1.288 0.99
349_S 353_N 1.287 0.99
309_L 388_H 1.286 0.99
170_I 186_M 1.281 0.99
161_F 195_A 1.279 0.99
117_I 165_T 1.278 0.99
350_F 354_Y 1.275 0.99
304_E 307_Q 1.271 0.99
301_N 304_E 1.271 0.99
162_D 165_T 1.269 0.99
356_I 397_G 1.26 0.99
173_V 332_L 1.254 0.99
80_I 237_Y 1.249 0.99
389_E 392_D 1.246 0.98
346_D 349_S 1.243 0.98
40_I 47_Y 1.243 0.98
318_E 325_L 1.242 0.98
310_M 314_L 1.234 0.98
324_T 340_G 1.229 0.98
337_F 380_A 1.227 0.98
358_V 378_C 1.225 0.98
349_S 352_D 1.22 0.98
211_D 214_A 1.199 0.98
83_R 240_E 1.197 0.98
301_N 305_Y 1.191 0.98
348_G 358_V 1.163 0.97
315_S 318_E 1.158 0.97
313_A 335_I 1.156 0.97
41_D 48_R 1.148 0.97
313_A 316_Q 1.143 0.97
316_Q 320_V 1.141 0.97
219_F 238_V 1.137 0.97
71_N 75_R 1.134 0.97
37_S 40_I 1.13 0.97
37_S 48_R 1.129 0.97
81_N 211_D 1.127 0.97
105_W 196_K 1.126 0.97
202_A 223_S 1.118 0.96
38_Q 41_D 1.117 0.96
314_L 327_G 1.111 0.96
194_G 217_C 1.107 0.96
356_I 394_L 1.107 0.96
300_N 303_A 1.103 0.96
351_L 358_V 1.095 0.96
76_A 90_F 1.09 0.96
75_R 291_L 1.089 0.96
399_Q 403_R 1.082 0.96
71_N 292_E 1.08 0.95
147_N 151_T 1.073 0.95
312_Y 315_S 1.071 0.95
320_V 395_V 1.067 0.95
308_N 312_Y 1.066 0.95
289_A 293_Y 1.055 0.95
313_A 395_V 1.055 0.95
74_K 84_S 1.051 0.94
45_E 48_R 1.05 0.94
288_G 292_E 1.044 0.94
78_L 295_S 1.044 0.94
103_N 137_V 1.044 0.94
22_L 355_G 1.042 0.94
72_V 288_G 1.035 0.94
27_L 391_V 1.032 0.94
98_I 198_L 1.03 0.94
157_L 186_M 1.029 0.94
78_L 292_E 1.029 0.94
110_V 116_I 1.023 0.93
188_T 191_H 1.022 0.93
112_A 138_G 1.021 0.93
142_R 162_D 1.019 0.93
347_V 378_C 1.018 0.93
313_A 391_V 1.018 0.93
118_I 141_L 1.016 0.93
74_K 85_A 1.016 0.93
313_A 382_L 1.007 0.93
347_V 401_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kmjA10.99751000.201Contact Map0.72
4lw2A30.98281000.239Contact Map0.755
1t3iA20.99751000.246Contact Map0.733
3e9kA10.96061000.28Contact Map0.586
1eluA20.9361000.287Contact Map0.712
3caiA20.9311000.289Contact Map0.732
4hvkA10.88921000.305Contact Map0.663
1eg5A20.89161000.317Contact Map0.71
3a9zA20.92611000.318Contact Map0.74
1qz9A10.92121000.329Contact Map0.618
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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