| UniProt: | P0A6B7 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12677 | ||
| Length: | 404 (373) | ||
| Sequences: | 27767 | ||
| Seq/Len: | 74.44 |
| ISCS
Paralog alert: 0.93 [within 20: 0.43] - ratio of genomes with paralogs Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 276_R | 367_D | 4.143 | 1.00 | |
| 24_M | 28_T | 3.638 | 1.00 | |
| 138_E | 172_A | 3.522 | 1.00 | |
| 280_G | 370_I | 3.335 | 1.00 | |
| 276_R | 363_E | 3.059 | 1.00 | |
| 318_K | 375_K | 3.051 | 1.00 | |
| 272_G | 363_E | 3.048 | 1.00 | |
| 57_Q | 257_R | 3.036 | 1.00 | |
| 17_P | 21_E | 2.859 | 1.00 | |
| 96_H | 122_T | 2.766 | 1.00 | |
| 368_Y | 372_L | 2.634 | 1.00 | |
| 96_H | 142_R | 2.598 | 1.00 | |
| 96_H | 120_E | 2.58 | 1.00 | |
| 162_D | 165_A | 2.58 | 1.00 | |
| 21_E | 25_Q | 2.572 | 1.00 | |
| 271_R | 275_N | 2.506 | 1.00 | |
| 254_E | 257_R | 2.42 | 1.00 | |
| 72_T | 78_S | 2.333 | 1.00 | |
| 280_G | 283_D | 2.328 | 1.00 | |
| 134_L | 169_M | 2.304 | 1.00 | |
| 288_Y | 304_S | 2.273 | 1.00 | |
| 101_K | 125_A | 2.226 | 1.00 | |
| 218_V | 223_R | 2.194 | 1.00 | |
| 368_Y | 371_E | 2.174 | 1.00 | |
| 276_R | 280_G | 2.166 | 1.00 | |
| 147_L | 178_H | 2.138 | 1.00 | |
| 136_E | 139_A | 2.134 | 1.00 | |
| 136_E | 140_A | 2.133 | 1.00 | |
| 245_P | 248_Q | 2.128 | 1.00 | |
| 362_T | 365_E | 2.111 | 1.00 | |
| 138_E | 173_R | 2.108 | 1.00 | |
| 95_K | 146_I | 2.096 | 1.00 | |
| 275_N | 279_N | 2.091 | 1.00 | |
| 96_H | 145_T | 2.007 | 1.00 | |
| 125_A | 136_E | 1.99 | 1.00 | |
| 167_G | 177_Y | 1.975 | 1.00 | |
| 164_A | 168_E | 1.962 | 1.00 | |
| 280_G | 374_R | 1.943 | 1.00 | |
| 279_N | 283_D | 1.943 | 1.00 | |
| 56_N | 60_D | 1.939 | 1.00 | |
| 133_D | 136_E | 1.934 | 1.00 | |
| 57_Q | 253_G | 1.914 | 1.00 | |
| 202_F | 215_A | 1.89 | 1.00 | |
| 152_H | 184_S | 1.861 | 1.00 | |
| 138_E | 169_M | 1.86 | 1.00 | |
| 134_L | 165_A | 1.856 | 1.00 | |
| 20_A | 24_M | 1.842 | 1.00 | |
| 96_H | 144_D | 1.839 | 1.00 | |
| 168_E | 172_A | 1.835 | 1.00 | |
| 355_F | 369_T | 1.833 | 1.00 | |
| 165_A | 168_E | 1.823 | 1.00 | |
| 309_E | 312_S | 1.816 | 1.00 | |
| 181_A | 200_M | 1.814 | 1.00 | |
| 21_E | 24_M | 1.798 | 1.00 | |
| 280_G | 367_D | 1.794 | 1.00 | |
| 7_L | 369_T | 1.774 | 1.00 | |
| 284_I | 374_R | 1.726 | 1.00 | |
| 25_Q | 31_G | 1.704 | 1.00 | |
| 171_R | 196_K | 1.702 | 1.00 | |
| 91_Q | 119_F | 1.681 | 1.00 | |
| 278_W | 282_K | 1.666 | 1.00 | |
| 170_C | 175_I | 1.665 | 1.00 | |
| 135_K | 139_A | 1.657 | 1.00 | |
| 363_E | 367_D | 1.646 | 1.00 | |
| 67_R | 220_R | 1.642 | 1.00 | |
| 148_V | 175_I | 1.636 | 1.00 | |
| 18_R | 254_E | 1.619 | 1.00 | |
| 170_C | 177_Y | 1.605 | 1.00 | |
| 268_E | 272_G | 1.584 | 1.00 | |
| 56_N | 66_P | 1.576 | 1.00 | |
| 58_I | 215_A | 1.573 | 1.00 | |
| 283_D | 374_R | 1.573 | 1.00 | |
| 280_G | 371_E | 1.573 | 1.00 | |
| 148_V | 170_C | 1.565 | 1.00 | |
| 122_T | 140_A | 1.56 | 1.00 | |
| 82_A | 199_L | 1.553 | 1.00 | |
| 52_D | 56_N | 1.552 | 1.00 | |
| 167_G | 171_R | 1.545 | 1.00 | |
| 164_A | 194_Q | 1.539 | 1.00 | |
| 22_K | 254_E | 1.53 | 1.00 | |
| 124_L | 140_A | 1.525 | 1.00 | |
| 95_K | 144_D | 1.516 | 1.00 | |
| 75_A | 201_S | 1.514 | 1.00 | |
| 264_A | 268_E | 1.503 | 1.00 | |
| 374_R | 378_G | 1.503 | 1.00 | |
| 101_K | 123_Y | 1.499 | 1.00 | |
| 288_Y | 306_N | 1.499 | 1.00 | |
| 135_K | 138_E | 1.497 | 1.00 | |
| 269_R | 273_L | 1.494 | 1.00 | |
| 312_S | 316_A | 1.485 | 1.00 | |
| 169_M | 173_R | 1.467 | 1.00 | |
| 68_E | 220_R | 1.461 | 1.00 | |
| 316_A | 376_S | 1.459 | 1.00 | |
| 18_R | 258_I | 1.456 | 1.00 | |
| 204_G | 252_M | 1.449 | 1.00 | |
| 141_M | 169_M | 1.448 | 1.00 | |
| 269_R | 272_G | 1.439 | 1.00 | |
| 73_S | 77_E | 1.436 | 1.00 | |
| 98_I | 140_A | 1.425 | 1.00 | |
| 191_D | 194_Q | 1.419 | 1.00 | |
| 273_L | 363_E | 1.409 | 1.00 | |
| 150_I | 166_I | 1.406 | 0.99 | |
| 22_K | 25_Q | 1.402 | 0.99 | |
| 178_H | 201_S | 1.38 | 0.99 | |
| 278_W | 301_L | 1.377 | 0.99 | |
| 371_E | 375_K | 1.375 | 0.99 | |
| 60_D | 260_K | 1.373 | 0.99 | |
| 138_E | 142_R | 1.372 | 0.99 | |
| 65_D | 220_R | 1.37 | 0.99 | |
| 79_D | 106_A | 1.365 | 0.99 | |
| 282_K | 289_L | 1.36 | 0.99 | |
| 171_R | 198_D | 1.36 | 0.99 | |
| 80_N | 84_K | 1.348 | 0.99 | |
| 82_A | 178_H | 1.335 | 0.99 | |
| 53_I | 253_G | 1.328 | 0.99 | |
| 20_A | 28_T | 1.324 | 0.99 | |
| 182_T | 203_S | 1.317 | 0.99 | |
| 280_G | 284_I | 1.299 | 0.99 | |
| 274_R | 278_W | 1.297 | 0.99 | |
| 367_D | 371_E | 1.296 | 0.99 | |
| 20_A | 27_M | 1.295 | 0.99 | |
| 127_Q | 131_I | 1.294 | 0.99 | |
| 83_I | 149_S | 1.292 | 0.99 | |
| 98_I | 145_T | 1.28 | 0.99 | |
| 265_T | 268_E | 1.268 | 0.99 | |
| 277_L | 301_L | 1.267 | 0.99 | |
| 322_V | 353_I | 1.266 | 0.99 | |
| 138_E | 165_A | 1.26 | 0.99 | |
| 213_I | 252_M | 1.259 | 0.99 | |
| 141_M | 175_I | 1.255 | 0.99 | |
| 63_G | 191_D | 1.244 | 0.98 | |
| 279_N | 282_K | 1.239 | 0.98 | |
| 199_L | 218_V | 1.237 | 0.98 | |
| 57_Q | 260_K | 1.232 | 0.98 | |
| 97_I | 111_C | 1.231 | 0.98 | |
| 284_I | 370_I | 1.212 | 0.98 | |
| 277_L | 366_I | 1.21 | 0.98 | |
| 268_E | 271_R | 1.193 | 0.98 | |
| 277_L | 357_L | 1.193 | 0.98 | |
| 153_V | 297_A | 1.188 | 0.98 | |
| 17_P | 20_A | 1.188 | 0.98 | |
| 23_M | 251_G | 1.185 | 0.98 | |
| 127_Q | 133_D | 1.181 | 0.98 | |
| 303_V | 355_F | 1.181 | 0.98 | |
| 53_I | 257_R | 1.179 | 0.98 | |
| 21_E | 28_T | 1.174 | 0.98 | |
| 108_L | 123_Y | 1.174 | 0.98 | |
| 135_K | 165_A | 1.169 | 0.97 | |
| 142_R | 145_T | 1.162 | 0.97 | |
| 57_Q | 60_D | 1.155 | 0.97 | |
| 92_K | 95_K | 1.155 | 0.97 | |
| 312_S | 315_M | 1.151 | 0.97 | |
| 277_L | 280_G | 1.147 | 0.97 | |
| 99_T | 121_V | 1.146 | 0.97 | |
| 277_L | 355_F | 1.144 | 0.97 | |
| 269_R | 363_E | 1.14 | 0.97 | |
| 253_G | 257_R | 1.138 | 0.97 | |
| 278_W | 289_L | 1.137 | 0.97 | |
| 78_S | 201_S | 1.135 | 0.97 | |
| 277_L | 369_T | 1.134 | 0.97 | |
| 83_I | 111_C | 1.13 | 0.97 | |
| 157_I | 342_L | 1.13 | 0.97 | |
| 364_E | 367_D | 1.12 | 0.96 | |
| 79_D | 178_H | 1.109 | 0.96 | |
| 278_W | 291_G | 1.109 | 0.96 | |
| 276_R | 279_N | 1.107 | 0.96 | |
| 168_E | 171_R | 1.105 | 0.96 | |
| 122_T | 142_R | 1.101 | 0.96 | |
| 5_I | 368_Y | 1.096 | 0.96 | |
| 17_P | 28_T | 1.096 | 0.96 | |
| 318_K | 372_L | 1.094 | 0.96 | |
| 265_T | 269_R | 1.086 | 0.96 | |
| 108_L | 112_R | 1.086 | 0.96 | |
| 264_A | 267_M | 1.081 | 0.95 | |
| 7_L | 366_I | 1.08 | 0.95 | |
| 64_A | 217_Y | 1.076 | 0.95 | |
| 25_Q | 28_T | 1.072 | 0.95 | |
| 320_L | 372_L | 1.069 | 0.95 | |
| 18_R | 21_E | 1.066 | 0.95 | |
| 320_L | 369_T | 1.065 | 0.95 | |
| 91_Q | 97_I | 1.059 | 0.95 | |
| 277_L | 370_I | 1.054 | 0.95 | |
| 51_V | 249_I | 1.051 | 0.94 | |
| 276_R | 366_I | 1.048 | 0.94 | |
| 53_I | 57_Q | 1.044 | 0.94 | |
| 141_M | 145_T | 1.036 | 0.94 | |
| 69_I | 217_Y | 1.031 | 0.94 | |
| 83_I | 91_Q | 1.024 | 0.93 | |
| 254_E | 258_I | 1.024 | 0.93 | |
| 16_D | 258_I | 1.021 | 0.93 | |
| 272_G | 276_R | 1.02 | 0.93 | |
| 262_E | 265_T | 1.017 | 0.93 | |
| 216_L | 226_I | 1.014 | 0.93 | |
| 65_D | 68_E | 1.005 | 0.93 | |
| 22_K | 26_F | 1.004 | 0.93 | |
| 120_E | 142_R | 1.002 | 0.92 | |
| 83_I | 147_L | 1 | 0.92 | |
| 314_I | 322_V | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3lvmA | 2 | 1 | 100 | 0.32 | Contact Map | 0.726 |
| 4hvkA | 1 | 0.9406 | 100 | 0.347 | Contact Map | 0.665 |
| 3vaxA | 2 | 0.9282 | 100 | 0.369 | Contact Map | 0.697 |
| 1eg5A | 2 | 0.9381 | 100 | 0.371 | Contact Map | 0.722 |
| 4ixoA | 2 | 0.9059 | 100 | 0.383 | Contact Map | 0.671 |
| 3a9zA | 2 | 0.9406 | 100 | 0.384 | Contact Map | 0.763 |
| 1kmjA | 1 | 0.9059 | 100 | 0.385 | Contact Map | 0.716 |
| 4lw2A | 3 | 0.9059 | 100 | 0.395 | Contact Map | 0.739 |
| 1t3iA | 2 | 0.9257 | 100 | 0.396 | Contact Map | 0.741 |
| 1eluA | 2 | 0.8614 | 100 | 0.417 | Contact Map | 0.718 |
Sequence Conservation (Image Generated using WebLogo v3)